Session Type: Abstract Submissions (ACR)
Various autoantibodies have been reported in cancer patients, however, results are inconsistent. In dermatomyositis (DM), striking association between autoantibodies to p155/140 (transcription intermediary factor (TIF) 1gamma/alpha) and malignancy has been documented in several recent studies, however, whether this autoantibody specificity can also be found in malignancy without DM is not known. In the present study, anti-TIF1gamma/alpha and other specificities found in systemic autoimmune rheumatic diseases (SARD) were examined in breast cancer patients.
152 unselected breast cancer patients were enrolled to the study. Clinical information was collected from medical record and serum autoantibodies were tested by immunoprecipitation (IP) of 35S-methionine-labeled K562 cell extract and anti-Ro52 and -TIF1gamma ELISA. Immunofluorescence antinuclear antibodies (ANA) using HEp-2 slide were also tested.
By IP, anti-TIF1gamma/alpha was found in 2 cases and anti-PM-Scl was found in one case among myositis-specific autoantibodies. Interestingly, no other myositis-specific autoantibodies, scleroderma specific anti-topoisomerase I and –RNA polymerase III, or SLE-specific anti-Sm or ribosomal P antibodies were found. Among autoantibodies associated with SARD but not specific for particular diagnoses, anti-Su/Argonaute 2 (Ago 2) was found in 3% (4/152), anti-Ro60 in 4% (6/152) by IP and anti-Ro52 was positive in 6% (9/152) by ELISA. Anti-U1RNP or anti-Sm was not found, however, interestingly, rare autoantibodies specific for U5RNP were found in 2 cases. A case with anti-TIF1gamma/alpha also had anti-Ro60 and Su/Ago2 but all other cases had only one specific autoantibodies listed above. As a whole, 14.5% (22/152) of breast cancer patients had autoantibodies associated with SARD. Although autoantibody specificities that are generally common in SARD and occasionally found in healthy individuals, such as anti-Ro60, Ro52 and Su were the most common, 2 cases of anti-TIF1gamma/alpha and anti-U5RNP seems significant because other disease-specific autoantibodies were not detected. Among 152 breast cancer patients, 6 had rheumatoid arthritis (RA) and one had ankylosing spondylitis but none had polymyositis/dermatomyositis, scleroderma or SLE. All specific autoantibodies detected were not associated with the presence of rheumatic diseases except one case of RA with anti-Ro52.
Although the specificities that are generally common in SARD (anti-Ro60, Ro52 and Su) were most common, unique specificities such as anti-TIF1gamma/alpha and anti-U5RNP was found in sera from breast cancer patients.
M. Vázquez-Del Mercado,
B. T. Martín-Márquez,
R. Vargas Ramirez,
J. Y. F. Chan,
S. J. Calise,
E. K. L. Chan,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/autoantibodies-associated-with-inflammatory-myopathy-and-other-systemic-autoimmune-rheumatic-diseases-in-sera-from-breast-cancer-patients/