Background/Purpose: The cardiovascular risk of gout is already well known, and the debate over the cardiovascular risk of uric acid lower agents is currently hot. Although hyperuricemia has been reported to be associated with a higher cardiovascular risk, it is not yet conclusive and guidelines for the management in patients with hyperuricemia are still lacking. We investigated associations of serum uric acid level with cardiovascular disease (CVD) risk in general population.

Methods:

We examined data from a survey conducted during the first and second years of the seventh Korea National Health and Nutrition Examination Survey (KNHANES,2016-2017). We included subjects who were aged from 30 to 74 years without prevalent CVD. We estimated CVD risk by 10-year CVD risk score prediction formula. Fractional polynomial model was chosen to estimate relationship of serum uric acid, physical activity, and BMI with 10-year CVD risk score.

Results: There was no significant difference of 10-year CVD risk score in men by serum uric acid level, but there was significant difference in women. In the fitted fractional polynomial model, an approximate U-shaped association between serum uric acid level and 10-year CVD risk score with an inflection point at 6.9 mg/dL of serum uric acid level in men was found. An approximate J-shaped association between serum uric acid level and 10-year CVD risk score in women was found.
There was no significant difference of 10-year CVD risk score in men by serum uric acid level, but there was significant difference in women. In the fitted fractional polynomial model, an approximate U-shaped association between serum uric acid level and 10-year CVD risk score with an inflection point at 6.9 mg/dL of serum uric acid level in men was found. An approximate J-shaped association between serum uric acid level and 10-year CVD risk score in women was found.

Conclusion:

Our study showed that hyperuricemia is associated with increased CVD risk, hypouricemia is also associated with increased CVD risk in men and practicing aerobic physical activity and lower BMI is associated with reduced CVD risk.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/associations-of-serum-uric-acid-with-cardiovascular-disease-risk-data-from-the-korea-national-health-and-nutrition-examination-survey/