Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Vitamin D deficiency is highly prevalence, especially in adults and elderly population. There is controversy about its relationship with increased cardiovascular risk, osteoporosis and bone fractures.
To describe the vitamin D levels in a population evaluated with suspected osteoporosis in a Bone Metabolism Unit and its relationship to other diseases.
We selected the patients attended in the Bone Metabolism Unit of the Hospital of Mérida between June 2013 and June 2014 that have at least one determination of 25-OH-cholecalciferol, bone densitometry and complete clinical history.
We included 171 patients between 34 and 75 years (mean 64.5, SD 11.75), 11 men and 160 postmenopausal women. The detected levels of 25-OH-cholecalciferol were normal (>30ng/ml) in 75 and deficient in 96 patients (56.14%). Deficiency was severe (<10ng/ml) in 11, moderate (10 to 20ng/ml) in 48 and mild (between 20 and 30ng/ml) in 37 patients. We didn´t find any correlation (Pearson coefficient) between the levels of 25-OH-cholecalciferol and age (-0.17), lumbar spine T-score (0.1) and hip T-score (-0.004), major and hip fracture risk using FRAX without BMD (0.13 for both) and with BMD (-0.017 and -0.063, respectively). Neither we didn´t find any association between levels of 25-OH-cholecalciferol and the existence of comorbidities and cardiovascular risk. Patients with severe deficiency (<10ng/ml) of 25-OH-cholecalciferol had higher rates of presence of cardiovascular risk factors (RR 5.87, 95%CI 1.16, 1.87) and bone fractures (OR 3.76 95%CI 1.75, 13.18).
Severe deficiency of 25-OH-cholecalciferol was significantly associated with the presence of bone fractures, irrespective of BMD values and FRAX risk. Levels below 10ng/ml of 25-OH-cholecalciferol were more frequent in patients who had at least one cardiovascular risk factor. No association between vitamin D deficiency and the presence of comorbidities was found.
To cite this abstract in AMA style:Chamizo Carmona E, Aznar Sánchez JJ, Veroz Gonzalez R, Rodriguez Araya TL, Cossio Jimenez PJ, Rojas Herrera SM. Associations Between Vitamin D Insufficiency, Osteoporotic Fractures and Comorbidites [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/associations-between-vitamin-d-insufficiency-osteoporotic-fractures-and-comorbidites/. Accessed August 14, 2020.
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