Associations Between Vitamin D Insufficiency, Osteoporotic Fractures and Comorbidites

Eugenio Chamizo Carmona¹, Juan Jose Aznar Sánchez^1,2, Raul Veroz Gonzalez², Tamara Libertad Rodriguez Araya¹, Piter José Cossio Jimenez² and Sara María Rojas Herrera³, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Mérida, Spain, ³Rheumatolotgy, Hospital de Mérida, Mérida, Spain

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Cardiovascular disease, Co-morbidities, fracture risk and osteoporosis

Session Information

Date: Sunday, November 8, 2015

Title: Osteoporosis and Metabolic Bone Disease - Clinical Aspects and Pathogenesis Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Vitamin D deficiency is highly prevalence, especially in adults and elderly population. There is controversy about its relationship with increased cardiovascular risk, osteoporosis and bone fractures.

To describe the vitamin D levels in a population evaluated with suspected osteoporosis in a Bone Metabolism Unit and its relationship to other diseases.

Methods:

We selected the patients attended in the Bone Metabolism Unit of the Hospital of Mérida between June 2013 and June 2014 that have at least one determination of 25-OH-cholecalciferol, bone densitometry and complete clinical history.

Results:

We included 171 patients between 34 and 75 years (mean 64.5, SD 11.75), 11 men and 160 postmenopausal women. The detected levels of 25-OH-cholecalciferol were normal (>30ng/ml) in 75 and deficient in 96 patients (56.14%). Deficiency was severe (<10ng/ml) in 11, moderate (10 to 20ng/ml) in 48 and mild (between 20 and 30ng/ml) in 37 patients. We didn´t find any correlation (Pearson coefficient) between the levels of 25-OH-cholecalciferol and age (-0.17), lumbar spine T-score (0.1) and hip T-score (-0.004), major and hip fracture risk using FRAX without BMD (0.13 for both) and with BMD (-0.017 and -0.063, respectively). Neither we didn´t find any association between levels of 25-OH-cholecalciferol and the existence of comorbidities and cardiovascular risk. Patients with severe deficiency (<10ng/ml) of 25-OH-cholecalciferol had higher rates of presence of cardiovascular risk factors (RR 5.87, 95%CI 1.16, 1.87) and bone fractures (OR 3.76 95%CI 1.75, 13.18).

Conclusion:

Severe deficiency of 25-OH-cholecalciferol was significantly associated with the presence of bone fractures, irrespective of BMD values and FRAX risk. Levels below 10ng/ml of 25-OH-cholecalciferol were more frequent in patients who had at least one cardiovascular risk factor. No association between vitamin D deficiency and the presence of comorbidities was found.

Disclosure: E. Chamizo Carmona, None; J. J. Aznar Sánchez, None; R. Veroz Gonzalez, None; T. L. Rodriguez Araya, None; P. J. Cossio Jimenez, None; S. M. Rojas Herrera, None.

To cite this abstract in AMA style:

Chamizo Carmona E, Aznar Sánchez JJ, Veroz Gonzalez R, Rodriguez Araya TL, Cossio Jimenez PJ, Rojas Herrera SM. Associations Between Vitamin D Insufficiency, Osteoporotic Fractures and Comorbidites [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/associations-between-vitamin-d-insufficiency-osteoporotic-fractures-and-comorbidites/. Accessed .

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