Association of Serum KL-6 Level and Change of Pulmonary Function in Interstitial Lung Disease of Rheumatoid Arthritis - Data from Prospective KOrean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) Study

Jeong Seok Lee¹, Young Im Yoon ², Eun Young Lee ³, Jung Yoon Choe ⁴, Hwa Jung Lee ⁵, Yong-Beom Park ⁶, Eun Ha Kang ⁷, You-Jung Ha ⁷, Yeon-Ah Lee ⁸ and Seong Hye Jang ⁹, ¹Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, ²Seoul National University Hospital, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, ⁴Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, Republic of Korea, ⁵DAEGU CATHOLIC UNIVERSITY, Daegu, Republic of Korea, ⁶Yonsei university college of medicine, severance hospital, Seodaemun-gu, Seoul-t'ukpyolsi, Republic of Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, ⁸School of Medicine, Kyung Hee University, Seoul, Republic of Korea, ⁹Soonchunhyang University, Cheonan, Republic of Korea

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: interstitial lung disease, KL-6 and pulmonary function test, Rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 12, 2019

Title: RA – Diagnosis, Manifestations, & Outcomes Poster III: Comorbidities

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Interstitial lung disease (ILD) is the most common lung disease among rheumatoid arthritis (RA) patients. Although the overall mortality rates for RA have decreased in general, ILD is associated with increased morbidity and mortality of RA patients, especially in older age groups. We have launched a multicenter prospective cohort of RA-ILD named as KOrean Rheumatoid Arthritis Interstitial Lung disease (KORAIL) cohort, to explore clinical prognosis using biomarkers and imaging modalities. This is the first disclosure of results originated from KORAIL cohort.
To describe general clinical characteristics of KORAIL cohort. To elucidate the role of serum concentration of Krebs von den Lungen-6 (KL-6), a potential biomarker of ILD, in evaluation of current status and prediction of functional change during first 1 year after enrollment. The association between KL-6 concentration and inflammatory cytokines were also investigated.

Methods: Entering clinical information to e-case report form, chest CT, pulmonary function test, and blood samples were conducted at baseline and followed every year. Serum KL-6 concentration (U/mL) was measured through the Nanopia KL-6 assay latex-enhanced immunoturbidimetric assay method. Multiplex ELISA was used to measure serum concentration of TNF-alpha, IL-6, GM-CSF, and IL-17.

Results: One hundred and sixty eight patients with RA-ILD have been enrolled from six university hospitals in Korea. Till January 2019, 129 patients (76.8%) were followed for 1 year, 71 patients (42.3%) for 2 years, and 21 patients (12.5%) for 3 years. RA was diagnosed at 58.7±11.3 (mean±SD, years old), ILD at 63.7±8.6, and enrolled at 66.4±8.0. Baseline KL-6 was significantly associated with baseline DLCO (r=-0.196, p=0.029), 1 year change(%) of FVC (r=-0.319, p=0.001) (figure A) and DLCO (r=-0.191, p=0.048)(figure B). TNF-alpha, IL-6, GM-CSF, and IL-17 had no association with functional deterioration or KL-6.

Conclusion: KL-6 could predict functional deterioration of RA-ILD in next 1 year.

Higher baseline KL-6 could predict functional deterioration of RA-ILD in next 1 year

Disclosure: J. Lee, None; Y. Yoon, None; E. Lee, None; J. Choe, None; H. Lee, None; Y. Park, None; E. Kang, Seoul National University Bundang Hospital, 3; Y. Ha, Seoul National University Bundang Hospital, 3; Y. Lee, None; S. Jang, None.

To cite this abstract in AMA style:

Lee J, Yoon Y, Lee E, Choe J, Lee H, Park Y, Kang E, Ha Y, Lee Y, Jang S. Association of Serum KL-6 Level and Change of Pulmonary Function in Interstitial Lung Disease of Rheumatoid Arthritis – Data from Prospective KOrean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) Study [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/association-of-serum-kl-6-level-and-change-of-pulmonary-function-in-interstitial-lung-disease-of-rheumatoid-arthritis-data-from-prospective-korean-rheumatoid-arthritis-interstitial-lung-disease-kor/. Accessed .

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