ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 912

Association of Adiposity Measures in Childhood and Adulthood with Knee Cartilage Thickness, Volume and Bone Area in Young Adults

Tao Meng1, Alison Venn1, Felix Eckstein2,3, Wolfgang Wirth2,3, Flavia Cicuttini4, Lyn March5, Terence Dwyer1,6, Marita Cross5, Laura Laslett1, Graeme Jones1, Changhai Ding1,7 and Benny Samuel Eathakkattu Antony1, 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2Chondrometrics GmbH, Ainring, Germany, 3Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, 4Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, 5Institute of Bone and Joint Research, University of Sydney, Sydney, Australia, 6The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, United Kingdom, 7Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, October 21, 2018

Title: 3S093 ACR/ARHP Abstract: Epidemiology & Pub Health (910–915)

Session Type: ACR/ARHP Combined Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: Adiposity is associated with increased risk of knee osteoarthritis; cartilage thickness, cartilage volume and subchondral bone area are established biomarkers in knee osteoarthritis. We aimed to describe the longitudinal associations of childhood and adulthood adiposity measures with knee cartilage thickness, volume and bone area in young adults.

Methods: Childhood and adulthood adiposity measures (weight, height, waist circumference and hip circumference) of 186 participants were collected in 1985 (aged 7-15 years) and during 2004-2006 (aged 26-36 years). Knee magnetic resonance imaging was conducted during 2008-2010 (aged 31-41 years), and cartilage thickness, volume and bone area were measured using a quantitative approach (Chondrometrics, Germany). Linear regressions were used to examine the above associations.

Results: The prevalence of overweight was 7.6% in childhood and 42.1% in adulthood. Childhood weight was negatively associated with adult patellar bone area (β=-6.24, 95% confidence interval (CI) -10.25 to -2.22 mm2/kg), while adult weight was positively associated with bone area in medial femorotibial compartment (MFTC) (β=3.09, 1.44 to 4.74 mm2/kg) and lateral femorotibial compartment (LFTC) (β=1.85, 0.19 to 3.51 mm2/kg). Adult waist-hip ratio (WHR) was negatively associated with cartilage thickness (MFTC: β=-0.011, -0.022 to 0.000; LFTC: β=-0.013, -0.025 to -0.002 mm/0.01 unit), volume (Patella: β=-21.85, -37.77 to -5.93; LFTC: β=-23.87, -42.18 to -5.57 mm3/0.01 unit) and bone area (Patella: β=-4.69, -8.26 to -1.12; LFTC: β=-4.76, -9.47 to -0.06 mm2/0.01 unit). The change in WHR z-scores from childhood to adulthood was negatively associated with cartilage thickness (MFTC: β=-0.056, -0.109 to -0.003 mm), volume (patella: -83.10, -162.97 to -3.23; MFTC: -83.04, -158.07 to -8.00; LFTC: -100.55, -190.28 to -10.81 mm3) and bone area (patella: -21.35, -39.00 to -3.69; LFTC: -24.47, -47.36 to -1.58 mm2). 

Conclusion: Childhood weight was negatively but adult weight was positively associated with adult bone area. Adult WHR and the change in WHR from childhood to adulthood were negatively associated with cartilage thickness, volume and bone area. These suggest early life adiposity measures may affect knee structures in young adults.


Disclosure: T. Meng, None; A. Venn, None; F. Eckstein, None; W. Wirth, None; F. Cicuttini, None; L. March, None; T. Dwyer, None; M. Cross, None; L. Laslett, None; G. Jones, None; C. Ding, None; B. S. Eathakkattu Antony, None.

To cite this abstract in AMA style:

Meng T, Venn A, Eckstein F, Wirth W, Cicuttini F, March L, Dwyer T, Cross M, Laslett L, Jones G, Ding C, Eathakkattu Antony BS. Association of Adiposity Measures in Childhood and Adulthood with Knee Cartilage Thickness, Volume and Bone Area in Young Adults [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/association-of-adiposity-measures-in-childhood-and-adulthood-with-knee-cartilage-thickness-volume-and-bone-area-in-young-adults/. Accessed .

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