Session Information
Date: Monday, November 13, 2023
Title: Abstracts: Vasculitis – Non-ANCA-Associated & Related Disorders I: Imaging
Session Type: Abstract Session
Session Time: 2:00PM-3:30PM
Background/Purpose: Patients with giant cell arteritis (GCA) have an increased risk of developing thoracic aortic aneurysms. Retrospective studies have shown that 18F-fluorodeoxyglucose (FDG) uptake in large vessels at diagnosis increases the risk of developing aortic complications during follow-up. The aim of this study was to prospectively evaluate the association between FDG uptake in large vessels at diagnosis and the evolution of aortic diameter and volume in GCA patients.
Methods: GCA patients who have had FDG positron emission tomography (PET) imaging at diagnosis ≤3 days after initiation of glucocorticoids and who were prospectively followed for ≥2 years were included. PET scans were semi quantitatively scored (0-3) at 7 vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21. PET scans were considered positive in case of FDG uptake ≥ grade 2 in any large vessel. Patients underwent computed tomography (CT) imaging at diagnosis and yearly thereafter for a maximum of 10 years. The association between vascular FDG uptake and aortic dimensions was estimated by linear mixed effect models with random intercept and slope in time adjusted for age, sex, AORTA score, CT or PET/CT scan and intravenous contrast. The ascending aorta, aortic arch, and descending aorta were considered aneurysmatic when the diameter was ≥45, ≥40, and ≥35 mm, respectively.
Results: Hundred patients (mean age 70 years, 68% females) were included, of which 74 (74%) had FDG uptake ≥ grade 2 in any large vessel. The 2022 ACR/EULAR GCA criteria were fulfilled in 89 (89%) patients. Median follow-up was 80 months (IQR 47-110). The increase in ascending and descending aortic diameter and in thoracic aortic volume was higher in patients with a positive PET scan compared to those without (difference in 5-year progression 1.53 mm [95%CI 0.36-2.70 mm], 1.22 mm [95%CI 0.28-2.16 mm] and 20.29 cm³ [95%CI 4.07-36.57 cm³], respectively) (Table 1). These thoracic aortic dimensions were also significantly associated with TVS (Figure 1). FDG uptake was not associated with an increase in abdominal aortic diameters nor volume. Patients with a positive PET scan had a higher risk of developing thoracic aortic aneurysms (aHR 13.61, 95%CI 1.63-113.50) with a median time since diagnosis of 40 months (IQR 18-61). Thoracic aortic aneurysm developed in 13 of the 15 (87%) patients in a region with elevated FDG uptake at diagnosis. Two patients with high TVS (15 and 16) needed surgery for ascending aortic aneurysm.
Conclusion: Higher TVS was associated with greater yearly increase in thoracic aortic dimensions. Vascular FDG uptake at diagnosis was an independent risk factor for developing thoracic aortic aneurysm in GCA patients. Performing PET imaging at diagnosis may help to estimate the future risk of aortic aneurysm formation. Follow-up of aortic dimensions may be warranted in patients with thoracic aortic FDG uptake or high TVS.
To cite this abstract in AMA style:
Moreel L, Coudyzer W, Boeckxstaens L, Betrains A, Molenberghs G, Vanderschueren S, Claus E, Van Laere K, Blockmans D. Association Between Vascular FDG Uptake at Diagnosis and Evolution in Aortic Dimensions in Giant Cell Arteritis: A Prospective Study [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/association-between-vascular-fdg-uptake-at-diagnosis-and-evolution-in-aortic-dimensions-in-giant-cell-arteritis-a-prospective-study/. Accessed .« Back to ACR Convergence 2023
ACR Meeting Abstracts - https://acrabstracts.org/abstract/association-between-vascular-fdg-uptake-at-diagnosis-and-evolution-in-aortic-dimensions-in-giant-cell-arteritis-a-prospective-study/