Session Type: Poster Session (Sunday)
Session Time: 9:00AM-11:00AM
Background/Purpose: Our objectives are:
- To analyze the prevalence of comorbidities related to CV risk in a register of patients with spondyloarthritis (CoSpaR).
- To evaluate if there is an association between structural damage, the presence of atherosclerotic plaques, the endothelial function and the increased CV risk in patients with axSpA.
Methods: Eight-five patients with axSpA from the SpA registry from Cordoba (CoSpaR) were selected for a cross-sectional study. Patients were recruited in a probabilistic and sequential way from a SpA monographic ambulatory, and a complete clinical history, physical examination and a biochemical analysis were performed.
CV risk was evaluated by estimating the SCORE index and assessing the presence of atherosclerotic plaques through carotid ultrasound. The study of endothelial function was performed with laser doppler flowmetry, analyzing the response to reactive hyperemia, so as the increase in blood flow occurred after temporary occlusion of blood flow.
Data was collected and analyzed using SPSS v25 program. Independent-samples t test was used to evaluate the association between radiological characteristics and presence of atherosclerotic plaques. The linear lelationship between the variables has been measured by Pearson’s linear correlation coefficient. Multiple lineal regression (MLR) was performed to assess the variables potentially associated with increased SCORE. All comparisons were bilateral considering p≤0.05 as a significant result.
Results: Baseline characteristics are shown in table 1.Characteristics related with radiographic damage and CV risk are shown in table 2. Direct linear relationship was found between the CV risk measured by SCORE index and total, lumbar and cervical mSASSS, and the presence of bone bridges. Analysis of atherosclerotic plaques at the carotid showed that age, disease duration, and variables related to radiographic damage (total mSASSS, cervical spine mSASSS, lumbar spine mSASSS, and bone bridges) were significantly higher in patients with atherosclerotic plaques(p< 0.05). In addition, mSASSS in cervical spine (p=0.063) and age (p< 0.0001) were found to be associated with the SCORE index value and were predictors of increased CV risk in MLR analysis. Endothelial function (measured by Laser Doppler measurement of post ischemic reactive hyperemia) correlated inversely (p< 0,05) with total and lumbar mSASSS, as shown by the values of hyperemic area after occlusion was released.
Conclusion: The presence of atherosclerotic plaques in patients with axSpA is associated not only with age and disease duration, but also with the degree of radiographic damage present. Age and structural damage predicted the increased risk of CV disease observed in axSpA. Therefore, we have observed that older patients with axSpA and more structural damage, especially in the cervical spine, had a greater risk of CV disease. Endothelial disfunction is also found in patients with axSpA.
Funded by: JA PI-0139-2017
To cite this abstract in AMA style:Ladehesa-Pineda M, Castro M, Gomez-Garcia I, Seguí-Azpilcueta P, ábalos-Aguilera M, Segura-Ruiz R, Ortega R, Bautista-Aguilar L, Aranda-Varela I, López-Medina C, Garrido-Castro J, Lopez-Pedrera C, Escudero-Contreras A, Collantes-Estévez E, Jiménez-Gómez Y. Association Between Radiographic Progression and Cardiovascular Risk in Spondyloarthritis: Data from CoSpaR REGISTRY [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/association-between-radiographic-progression-and-cardiovascular-risk-in-spondyloarthritis-data-from-cospar-registry/. Accessed November 26, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/association-between-radiographic-progression-and-cardiovascular-risk-in-spondyloarthritis-data-from-cospar-registry/