Session Information
Date: Wednesday, November 16, 2016
Title: Osteoarthritis – Clinical Aspect II: Treatment and Imaging
Session Type: ACR Concurrent Abstract Session
Session Time: 9:00AM-10:30AM
Background/Purpose: Infrapatellar fat pad (IPFP), a local adipose tissue, may have important contributions to knee osteoarthritis (OA). IPFP signal intensity alterations on MRI may represent pathological changes such as inflammation and oedema. This study aims to describe the associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alterations and knee structural and symptomatic abnormalities in patients with symptomatic knee OA.
Methods: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA (assessed according to American College of Rheumatology criteria) were selected from a randomized controlled trial. IPFP signal intensity alteration was quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These included the mean value [Mean (IPFP)] and standard deviation [sDev (IPFP)] of whole IPFP signal intensity, median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity, volume of high signal intensity regions [Volume (H)] and the ratio of Volume (H) to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing clustering effect of high signal intensity. Signal intensity alteration (SIA) was also measured semi-quantitatively (grade 0-3). Cartilage defects, bone marrow lesions (BMLs) and radiographic OA (ROA) were measured. All measures except ROA were performed at both baseline and 24 months later. Linear regression analyses were performed after adjustment for age, sex, BMI, and/or intervention.
Results: Two hundred and sixty one participants (mean age 63.0 ± 7.2 years) participated in this study. There were no significant differences in demographic factors (age, sex, and BMI) between these participants and those unselected. sDve (IPFP), Median (H), UQ (H), Volume (H), Percentage (H) and Clustering factors (H) were associated with increased ROA at baseline in multivariable analyses. In the linear mixed-effects model, these measures were significantly and positively associated with cartilage defects and BMLs over 2 years in multivariable analyses. Mean (IPFP), sDev (IPFP), Median (H) and UQ (H) were also significantly associated with increased knee pain over 2 years (Table 1).
Conclusion: Quantitative measures of signal intensity alteration in IPFP were associated with knee structural and symptomatic abnormalities in patients with symptomatic knee OA, suggesting that IPFP signal intensity alterations may have a role to play in knee OA progression. Table 1. Associations of IPFP signal intensity alteration with cartilage defects and bone marrow lesions
|
Cartilage defects* |
Bone marrow lesions* |
|
|
β (95% CI) |
β (95% CI) |
|
| Mean (IPFP) |
3.18 (-4.74, 11.10) |
16.36 (6.27, 26.46) |
| sDev (IPFP) |
31.39 (15.87, 46.90) |
48.27 (31.19, 65.34) |
| Median (H) |
6.46 (1.76, 11.16) |
13.91 (8.49, 19.33) |
| UQ (H) |
4.71 (1.17, 8.26) |
10.06 (5.99, 14.14) |
| Volume (H) |
1.33 (0.66, 1.99) |
1.17 (0.46, 1.87) |
| Percentage (H) |
37.91 921.64, 54.18) |
46.36 (26.04, 66.69) |
| Clustering factor (H) |
0.78 (0.44, 1.13) |
1.16 (0.74, 1.58) |
| SIA |
0.57 (0.30, 0.84) |
0.83 (0.51, 1.15) |
*Adjusted for age, sex, BMI, treatment allocation and randomization.
To cite this abstract in AMA style:
HAN W, Jones G, Ding C. Association Between Quantitatively Measured Infrapatellar Fat Pad High Signal Intensity Alteration and Knee Structural and Symptomatic Abnormalities in Patients with Symptomatic Knee Osteoarthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/association-between-quantitatively-measured-infrapatellar-fat-pad-high-signal-intensity-alteration-and-knee-structural-and-symptomatic-abnormalities-in-patients-with-symptomatic-knee-osteoarthritis/. Accessed .« Back to 2016 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/association-between-quantitatively-measured-infrapatellar-fat-pad-high-signal-intensity-alteration-and-knee-structural-and-symptomatic-abnormalities-in-patients-with-symptomatic-knee-osteoarthritis/