Background/Purpose: Hyperuricemia and anemia may be related in terms of sharing comorbidities such as chronic kidney disease (CKD) and cardiovascular disease. However, to our knowledge, no studies have been conducted on the relationship between two conditions. The purpose of this study was to investigate the association between hyperuricemia and anemia using data from Korean National Health and Nutrition Examination Survey (KNHANES VII; 2016-2017), which is representative of the Korean population.

Methods: The present study included 10794 participants aged ≥ 19 years from KNHANES VII. Logistic regression was used to examine the association between anemia and hyperuricemia. Subgroup analysis was performed to confirm whether the association between two conditions varies according to participant characteristics.

Results: Because there were significant differences in baseline characteristics with and without hyperuricemia between subjects with CKD and subjects without CKD, we analyzed the association between hyperuricemia and anemia separately in subjects with and without CKD. The association between anemia and hyperuricemia was not evident in subjects without CKD, but the risk of hyperuricemia in patients with CKD was 2.2 times higher in patients with anemia. This association was also maintained when the glomerular filtration rate was adjusted (HR 2.34, 95% CI 1.20-4.56). In subgroup analysis, the association of anemia with hyperuricemia was significant in subjects aged 65 years and older, in men, in subjects with diabetes or hypertension, and in subjects with CKD. Subgroup analysis of subjects with CKD showed similar results.

Conclusion: In a Korean representative sample, the association of anemia with hyperuricemia was evident in CKD patients, which remained significant when GFR was adjusted. In addition, anemia and hyperuricemia were well correlated with older age, men, and comorbidity such as diabetes or hypertension.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/association-between-anemia-and-hyperuricemia-korean-national-health-and-nutrition-survey-2016-2017/