ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1627

Assessment of Myocardial Dysfunction Using Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis

Volkan Emren1, Onay Gercik2, Emre Ozdemir3, Dilek Solmaz2, Nihan Eren3, Mehmet Tokac3, Gökhan Kabadayı2, Sercan Gucenmez2 and Servet Akar4, 1Faculty Of Medicine, Department of Cardiology, Izmir Katip Celebi University, Izmir, Turkey, 2Rheumatology, Izmir Katip Celebi University, Faculty of Medicine, Izmir, Turkey, 3Faculty Of Medicine, Department Of Cardiology, Izmir Katip Celebi University, Izmir, Turkey, 4Faculty of Medicine, Department of Rheumatology, Izmir Katip Celebi University, Izmir, Turkey

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords:

Session Information

Date: Monday, October 22, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster II: Clinical/Epidemiology Studies

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects axial skeleton. Although some differences like sex and objective signs of inflammation were described between ankylosing spondylitis and non-radiographic (nr-) axSpA patients, overall disease burden was found to be similar in these subgroups of axSpA. The association of chronic inflammation with cardiac dysfunction was well documented in many inflammatory rheumatic diseases. However it was not assessed in the subgroups of axSpA. Advanced two-dimensional (2D) speckle tracking echocardiographic analysis is more sensitive and accurate method of early detection of myocardial dysfunction than the conventional 2D transthoracic echocardiography (TTE).Therefore the aim of this study was to evaluate the left ventricular function by using speckle tracking echocardiography in patients with both r- and nr-axSpA.

Methods: In total 72 patients with ankylosing spondylitis (72% male) and age– and sex-matched 38 patients with nr-axSpA (58% male) and 56 healthy control subjects (54% male) were included in the analysis. Patients with hypertension, diabetes and known cardiac disease were excluded. All patients underwent detailed echocardiographic examination including M-mode, pulsed-wave Doppler imaging, pulsed-wave tissue Doppler imaging and 2D speckle tracking.

Results: Age and sex distribution were not different between groups. Some demographic and disease related characteristics were shown in the table. BASDAI, BASFI, global assessment of disease activity and ASAS-HI scores were found to be similar between r- and nr-axSpA patient groups. Although ejection fraction (EF) (P=0.449) and the other echocardiographic variables were similar between groups, global longitudinal strain (GLS) (P=0.004) was found to be different among groups (table) in ANOVA analysis. Post-hoc tests showed that GLS was similar between nr-axSpA and control groups however GLS was significantly low in r-axSpA patients. In univariate analysis GLS was correlated with age (P=0.032) and peripheral arthritis (P=0.035). However in regression analysis peripheral arthritis (P=0.009) was found as the only independent predictor of GLS.

Conclusion: The results of the present study showed that left ventricular function had impaired in ankylosing spondylitis patients and impaired ventricular function might also be the other differentiating factor between radiographic and nr-axSpA patients.

Table. The demographic and disease related characteristics of study groups.

Ankylosing Spondylitis

(n=72)

Non-radiographic axSpA patients

(n=38)

Control subjects

(n=56)

p

Age, years (mean ± SD)

39.2 ± 9.9

37.0 ± 10.6

40.9 ± 7.2

0.137

Duration of disease, years (mean ± SD)

12.9 ± 8.1

8.0 ± 7.8

N/A

N/A

BASDAI, (mean ± SD)

2.8 ± 2.3

3.0 ± 1.7

N/A

N/A

BASFI, (mean ± SD)

2.7 ± 2.5

2.2 ± 1.9

N/A

N/A

Ejection fraction, (mean ± SD)

59.2 ± 5.3

59.9 ± 4.6

60.3 ± 4.6

0.449

Global Longitudinal Strain, (mean ± SD)

20.5 ± 3.3

21.1 ± 3.5

22.3 ± 2.4

0.004

Disclosure: V. Emren, None; O. Gercik, None; E. Ozdemir, None; D. Solmaz, None; N. Eren, None; M. Tokac, None; G. Kabadayı, None; S. Gucenmez, None; S. Akar, None.

To cite this abstract in AMA style:

Emren V, Gercik O, Ozdemir E, Solmaz D, Eren N, Tokac M, Kabadayı G, Gucenmez S, Akar S. Assessment of Myocardial Dysfunction Using Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/assessment-of-myocardial-dysfunction-using-speckle-tracking-echocardiography-in-patients-with-ankylosing-spondylitis-and-nonradiographic-axial-spondyloarthritis/. Accessed .

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