Background/Purpose
To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis.
Methods
Using large-cohort administrative data from Quebec, Canada, we identified all patients with vasculitis, including those with polyarteritis nodosa and granulomatosis with polyangiitis. Incident myocardial infarctions and cerebrovascular events after the diagnosis of vasculitis were ascertained longitudinally via billing and hospitalization data and compared to rates of a general population comparator group. The incidences of comorbidities (DMII, dyslipidemia, and hypertension) were also collected.
Results
Among the 836 patients identified with vasculitis, the myocardial infarction event rate was substantially higher in younger patients, with rates up to 268.1 events per 10,000 pt years [95% CI 67.1-1070.2] in males aged 18-45 with polyarteritis nodosa, approximately 30 times that seen in the age- and sex-matched control group. The cerebrovascular event rate was also substantially higher, particularly in adults aged 45-65 regardless of vasculitis type. All patient groups with vasculitis had elevated incidences of diabetes, dyslipidemia and hypertension compared to the general population.
Conclusion
Atherothrombotic event rates were elevated in patients identified as having primary systemic vasculitis. While incident rates of cardiovascular comorbidities were also increased, the substantial elevation in myocardial infarctions seen in young adults suggests a disease-specific component which requires further investigation.
Disclosure:
A. Tsoukas,
None;
S. Bernatsky,
None;
L. Joseph,
None;
D. Buckeridge,
None;
P. Belisle,
None;
C. A. Pineau,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/arterial-thrombotic-events-in-systemic-vasculitis/