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Abstract Number: 1802

Are Outcomes after Total Knee Arthroplasty Worsening over Time? a Time-Trends Study of Activity Limitation and Pain Outcomes

Jasvinder A. Singh1 and David Lewallen2, 1University of Alabama and VA Medical Center, Birmingham, AL, 2Orthopedics, Mayo Clinic college of medicine, Rochester, MN

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Arthroplasty, functional status and outcomes, Hip

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Session Information

Session Title: Epidemiology and Public Health II: Osteoarthritis, Sedentary Behavior and more

Session Type: Abstract Submissions (ACR)

Background/Purpose: To examine whether function and pain outcomes of patients undergoing primary total knee arthroplasty (TKA) are changing over time.

Methods: The Mayo Clinic Total Joint Registry provided data for time-trends in preoperative and 2-year post-operative activity limitation and pain in primary TKA patients from 1993-2005.  We used chi-square test and analysis for variance, as appropriate.  Multivariable-adjusted analyses were done using logistic regression. 

Results: In a cohort of 7,229 patients who underwent primary TKA during 1993-2005, mean age was 68.4 years (standard deviation (SD), 9.8), mean BMI was 31.1 (SD, 6.0) and 55% were women.  Crude estimates showed that preoperative moderate-severe overall limitation were seen in 7.3% fewer patients and preoperative moderate-severe pain in 2.7% more patients in 2002-05, compared to 1992-95 (p<0.001 for both).  At 2-years, crude estimates indicated that compared to 1992-95, moderate-severe post-TKA overall limitation was seen in 4.7% more patients and moderate-severe post-TKA pain in 3.6% more patients in 2002-05, both statistically significant (p²0.018) and clinically meaningful.  In multivariable-adjusted analyses that adjusted for age, sex, anxiety, depression, Deyo-Charlson index, body mass index and preoperative pain/limitation, patients had worse outcomes 2-year post-TKA in 2002-2005 compared to 1993-95 with an odds ratio (95% confidence interval (CI); p-value) of 1.34 (95% CI: 1.02, 1.76, p=0.037) for moderate-severe activity limitation and 1.79 (95% CI: 1.17, 2.75, p=0.007) for moderate-severe pain.

Conclusion: Patient-reported function and pain outcomes after primary TKA have worsened over the study period 1993-95 to 2002-05.  This time-trend is independent of changes in preoperative pain/limitation and patient characteristics.     


Disclosure:

J. A. Singh,

takeda, savient,

2,

takeda, savient, regeneron, allergan,

5;

D. Lewallen,

Zimmer, Orthosonic and Osteotech,

8,

Pipeline Biomedical ,

5,

DePuy, Stryker, Biomet and Zimmer.,

2.

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