Are Metabolic Factors Associated with Shoulder Osteoarthritis? a Multicentric Study.

Pierre-Antoine Juge¹, Laure Bérard², Salma Kotti³, Tabassome Simon⁴, Francis Berenbaum⁵, Geoffroy Nourissat⁶ and Jérémie Sellam⁷, ¹Rheumatology Department, Saint-Antoine Hospital, Paris, France, ²Rheumatology Department, Le Havre Hospital, Le Havre, France, ³Unité de Recherche Clinique de l’Est Parisien, Saint-Antoine Hospital, Paris, France, ⁴Unité de Recherche Clinique de l'Est Parisien URCEST, Saint-Antoine Hospital, AP-HP, Univ Paris 06, Paris, France, ⁵Rheumatology, Inserm UMRS_938, AP-HP, St Antoine Hospital, Univ Paris 06, DHU i2B, Paris, France, ⁶Orthopedic surgery, Clinique des Maussins & St-Antoine Hospital AP-HP, Paris, France, ⁷Rheumatology and Inserm UMRS_938, AP-HP, St Antoine Hospital, Univ Paris 06, DHU i2B, Paris, France

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Diabetes, metabolic syndrome, obesity, osteoarthritis and shoulder disorders

Session Information

Date: Sunday, November 8, 2015

Title: Osteoarthritis - Clinical Aspects Poster I: Treatments and Metabolic Risk Factors

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Aging, trauma and obesity are the 3 main risk factors for knee, hip and hand osteoarthritis (OA). It is noteworthy that risk factors for shoulder OA (SOA) have been much less studied. SOA is divided into 2 anatomical subtypes: i) primary SOA (i.e., centered SOA) and ii) rotator cuff-related OA (i.e., non-centered SOA). We hypothesized that metabolic factors are preferentially associated with the primary SOA than the mechanical-induced rotator cuff-related SOA.

Methods: This 2004-2012 retrospective multicentric study included patients with SOA at the time of joint surgery from 1 rheumatology and 2 orthopedic departments specialized in upper limb surgery. Clinical characteristics, especially hypertension, dyslipidemia, obesity (defined as body mass index >30), type 2 diabetes mellitus, current/past smoking, cardiovascular diseases and dysthyroidism were collected using medical files and phone calls to the patients for missing data. Primary SOA and rotator cuff-related SOA were defined by rheumatologists or surgeons using the standard radiographs. Exclusion criteria were history of a high-energy trauma on the shoulder, chronic inflammatory arthritis, avascular necrosis of the humeral head and age below 30 years-old. We first compared primary SOA and rotator cuff-related SOA using the chi-2 or Student t-test for all characteristics. Then a multivariate analysis using logistic regression was performed to determine specific factors associated with primary SOA.

Results: We included 147 patients (mean ± SD age 75.8 ±10 years-old) including 101 women (68.7%). Primary SOA involved 99 patients and the other 48 had rotator cuff-related SOA. The comparison between the 2 groups indicated that primary SOA patients were older (primary SOA versus rotator cuff arthropathy: 77.5 ±9 vs 72.4 ±11 years-old; p=0.004) and had more dysthyroidism (15% vs 4%; p=0.05) without difference in each cardio-metabolic disturbance (body mass index: 27.2 ±5.1 vs 27.3 ±4.5; type 2 diabetes: 13% vs 15%; hypertension: 64% vs 66%; dyslipidemia: 36% vs 31% p=non-significant) or in their accumulation between the 2 groups.

Multivariate analysis indicated that older age was independently associated with primary SOA (odds ratio 95% confidence interval): 1.06 (1.02-1.1) p=0.004), while cardiovascular event diseases was more less associated with this subtype (OR (95%IC): 0.27 (0.089-0.824); p=0.02). Dysthyroidism tended to be also associated with primary SOA (OR (95%IC): 3.47 (0.67-18.9); p=0.14).

Conclusion: Conversely to what expected, metabolic disturbances were not more prevalent in the primary SOA compared to the rotator cuff-related SOA. Surprisingly, whereas the primary OA population was older, CV diseases were more frequent in the rotator cuff-related SOA.

Disclosure: P. A. Juge, None; L. Bérard, None; S. Kotti, None; T. Simon, None; F. Berenbaum, None; G. Nourissat, None; J. Sellam, None.

To cite this abstract in AMA style:

Juge PA, Bérard L, Kotti S, Simon T, Berenbaum F, Nourissat G, Sellam J. Are Metabolic Factors Associated with Shoulder Osteoarthritis? a Multicentric Study. [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/are-metabolic-factors-associated-with-shoulder-osteoarthritis-a-multicentric-study/. Accessed .

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