ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2841

Anti-Ro52/TRIM21 Antibodies Are Associated with QT Interval Prolongation in Patients with Systemic Lupus Erythematosus

Luis F. Perez-Garcia1, Irving Omar Estevez-Garcia1, Mariana Moreno Ramirez1, Javier Loaiza Felix1, Ricardo Marquez-Velasco2, Pedro Iturralde3, Luis H. Silveira4,5 and Luis M. Amezcua-Guerra1, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Cardiology - Electrophysiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 4Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, 5Instituto Nacional de Cardiologia Ignacio Chavez, Mexico city, Mexico

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Antibodies

  • Tweet
  • Email
  • Print
Session Information

Date: Tuesday, November 15, 2016

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment - Poster III: Biomarkers and Nephritis

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Long QT syndrome (LQTS) is characterized by an abnormal QT corrected (QTc) interval prolongation that is associated with increased risk of sudden death. Studies have associated LQTS with several rheumatic conditions, and evidence points towards a link between the degree of systemic inflammation and the duration of QTc interval. Moreover, recent evidence suggests that anti-Ro antibodies may play a role in the QTc prolongation by mechanisms not fully understood, thus constituting a novel autoimmune-mediated LQTS. This study was aimed to assess whether QTc interval prolongation is associated with the presence of anti-Ro antibodies in SLE, particularly with reactivities against Ro52/TRIM21 antigens.

Methods: Consecutive patients fulfilling the 1997 ACR criteria for SLE were included. Patients with history of ischemic heart disease, with implantable pacemakers, and those taking drugs that potentially could affect QT interval (except for antimalarials) were excluded. Patients underwent a resting 12-lead electrocardiogram recording to measure QT interval corrected by BazzetÕs formula. A QTc interval duration greater than 460 msec in women and 440 msec in men was set to be abnormal. Serum anti-Ro and anti-Ro52/TRIM21 antibody levels were measured by ELISA. Data were expressed as frequencies and means (± standard deviation), and differences were tested by YatesÕ continuity corrected chi square or Mann-Whitney tests, while linear regressions were performed to assess linearity between autoantibody levels and QTc duration. The GraphPad Prism 4.02 software was used for calculations.

Results: Sixty-six patients with mean age of 39±13 years (57 female gender) were included. A QTc prolongation was found in 10 patients (15%), with mean QTc interval of 470±18 msec as compared to 414±23 msec in those with no LQTS. Main clinical and demographic characteristics were similar for both groups, except for a lesser use of antimalarials and higher serum creatinine levels in patients with LQTS. Disease activity was similar between groups.Anti-Ro antibody levels were significantly higher in patients with prolonged QT interval (75±66 U/mL versus 29±44 U/mL; P=0.005); similarly, anti-Ro52/TRIM21 levels were higher in those with LQTS (50±55 U/mL versus 14±30 U/mL; P=0.01). Notably, a linear association (see the Figure) between the QTc intervals and levels of anti-Ro antibodies (r2=0.073; P=0.02) and anti-Ro52/TRIM21antibodies (r2=0.078; P=0.02) was observed.

Conclusion: Our results strengthen the hypothesis that a specific autoantibody-mediated LQTS occur in SLE patients positive to anti-Ro antibodies. This interference in the ventricular repolarization appears to be associated with increased levels of antibodies against Ro52/TRIM21 antigens, and supports the realization of an electrocardiogram as part of the routinely evaluation in SLE patient with circulating anti-Ro antibodies.


Disclosure: L. F. Perez-Garcia, None; I. O. Estevez-Garcia, None; M. Moreno Ramirez, None; J. Loaiza Felix, None; R. Marquez-Velasco, None; P. Iturralde, None; L. H. Silveira, None; L. M. Amezcua-Guerra, None.

To cite this abstract in AMA style:

Perez-Garcia LF, Estevez-Garcia IO, Moreno Ramirez M, Loaiza Felix J, Marquez-Velasco R, Iturralde P, Silveira LH, Amezcua-Guerra LM. Anti-Ro52/TRIM21 Antibodies Are Associated with QT Interval Prolongation in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/anti-ro52trim21-antibodies-are-associated-with-qt-interval-prolongation-in-patients-with-systemic-lupus-erythematosus/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/anti-ro52trim21-antibodies-are-associated-with-qt-interval-prolongation-in-patients-with-systemic-lupus-erythematosus/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology