ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2581

Anti- Citrullinated Protein Antibodies but Not Rheumatoid Factor Are Associated with Larger Bone Erosions in rheumatoid arthritis patients- a Cross-Sectional Micro Computed Tomography Study

Carolin Hecht1, Stephanie Finzel1, Matthias Englbrecht1, Sarah Schmidt1, Juergen Rech2, Elizabeth Araujo1 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: anti-CCP antibodies, anti-citrullinated protein/peptide antibodies (ACPA), Biomarkers, computed tomography (CT) and rheumatoid arthritis (RA)

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Imaging of Rheumatic Diseases III: Computed Tomography

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Anti- citrullinated protein antibodies (ACPA) are known to be associated with joint destruction and a more severe disease course in rheumatoid arthritis (RA) patients. Recently, ACPA have been identified to directly induce bone loss (1). No study, however, has yet compared ACPA-positive and ACPA-negative RA patients with respect to their periarticular bone structure using high-resolution imaging of bone.

 

Methods:

Cross-sectional analysis of 234 RA-patients fulfilling the new ACR/EULAR criteria. All patients received micro-computed tomography (2) of the MCP II, II and IV joints of the dominantly affected hand. Age, gender, disease activity (DAS28), disease duration, rheumatoid factor, ACPA (by anti-CCP2 ELISA) and anti-rheumatic therapy were recorded.

Number, width, depth and volume of bone erosion were assessed by 2 independent readers, one of them reading the images twice to test for intrareader-reliability. For calculation of volumes, a semi-ellipsoid formula was used (3).

 

Results:

137 patients were ACPA positive (RF+: N =108, RF-: N =29), 97 patients ACPA negative (RF+ . N =28, RF-: N =69). All 4 groups were comparable for age, gender, disease activity, disease duration and anti-rheumatic therapy (Tab. 1). 15 patients were excluded from further evaluation due to movement artefacts. RF+/ACPA+ RA patients had significantly more severe erosions (width: 2.00mm; depth: 2.25mm; volume: 13.86mm3) as compared to RF-/ACPA- RA patients (1.25mm; 2.02mm; 4.60mm3; all p<0.0001). Furthermore, when comparing only those patients without RF, we observed that bone erosions in RF-/ACPA+ RA patients were significantly larger in dimension than bone erosions in RF-/ACPA- RA patients (w-+/+-:p=0,0012; w-+/--: p<0.0001; d:-+/+-p=0,0095 and d:-+/--p=0,0347; vol-+/+-:p= 0,0133; vol-+/--:p=0,0055). Intra-observer reproducibility (CH) for erosion counts, width, depth and volumes was high (Spearman's rho between 0.93-0.99; p < 0.001). Interobserver reproducibility (SF; CH) was also very high (cts: 0.99, p < 0.001; w/d: 0.98, p < 0.001; vol.: 0.996, p < 0.001).

 

 

Conclusion:

These data show that ACPA-positivity is associated with larger bone erosions in patients with RA. They also support the notion that ACPA essentially contribute to bone loss in RA by enhancing osteoclast activity, which is the key prerequisite for bone erosion. Moreover, ACPA impact bone erosion independent from the presence or absence of RF.

 

References:

  1. Harre et al. Induction of osteoclastogenesis by human antibodies against cittrulinated vimentin. J Clin Investig 2012 May 1; 122(5)
  2. Stach CM et al. Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum. 2010 Feb;62(2):330-9.
  3. Albrecht, A., et al. The structural basis of MRI bone erosions – an assessment by micro-computed tomography [submitted]

 

 

 


Disclosure:

C. Hecht,
None;

S. Finzel,
None;

M. Englbrecht,
None;

S. Schmidt,
None;

J. Rech,
None;

E. Araujo,
None;

G. Schett,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2012 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/anti-citrullinated-protein-antibodies-but-not-rheumatoid-factor-are-associated-with-larger-bone-erosions-in-rheumatoid-arthritis-patients-a-cross-sectional-micro-computed-tomography-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology