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  • Abstract Number: 003 • 2023 Pediatric Rheumatology Symposium

    Inflammation or Infection? Understanding Linguistic and Cultural Nuances Impacting the Care of Somali Children with Juvenile Idiopathic Arthritis

    Emily Hause, Abdirazak Ali and Muna Sunni, University of Minnesota, Minneapolis, MN

    Background/Purpose: Data regarding the linguistic and cultural factors impacting the Somali patient experience and understanding with regards to juvenile idiopathic arthritis (JIA) are limited. We…
  • Abstract Number: 009 • 2023 Pediatric Rheumatology Symposium

    The Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program

    John Bridges1, Livie Huie2, Amanda Alexander2, Randy Cron2, Maria I. ("Maio") Danila3, Victoria Gennaro4, Laura Hughes2, Bailey Lipham5, Linda McAllister4, Matthew Mullen2, Annelle Reed6, Daniel Reiff2, Carolyn Smith6, Emily Smitherman2, Matthew Stoll2, Peter Weiser2 and Melissa Mannion2, 1University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, 4Children's of Alabama, Birmingham, AL, 5University of Alabama Medical School, Birmingham, AL, 6Children's of Alabama, Birmingham, AL

    Background/Purpose: Children with chronic rheumatic conditions age and require transfer to adult rheumatologists for continued care. The transition period from pediatric to adult-oriented care is…
  • Abstract Number: 012 • 2023 Pediatric Rheumatology Symposium

    Thrombotic Microangiopathic Changes in Kidney Biopsies of Childhood-Onset Systemic Lupus Erythematous Patients with and Without Severe Hematologic Disturbances

    Cathy Tsin1, Megan Troxell1, Vivek Charu1, Rufei Lu2 and Joyce Hsu3, 1Stanford University, Palo Alto, CA, 2UCSF, San Francisco, CA, 3Stanford Medicine, Children's Health, Palo Alto, CA

    Background/Purpose: Outcomes for pediatric patients with lupus nephritis (LN) remain suboptimal. LN may present with thrombotic microangiopathy (TMA) seen on kidney biopsy. Childhood-onset SLE patients…
  • Abstract Number: 002 • 2023 Pediatric Rheumatology Symposium

    Re-analysis of the APPLE (Atherosclerosis Prevention in Paediatric Lupus Erythematosus) Trial Identifies Novel Determinants of Patient Heterogeneity and a Distinct Lipid Metabolomic Signature of Atherosclerosis Progression

    Coziana Ciurtin1, Junjie Peng1, Pierre Donnes1, Stacy Ardoin2, Laura Schanberg3, Laura Lewandowski4, George A Robinson1 and Elizabeth Jury1, 1University College London, London, United Kingdom, 2Nationwide Children's Hospital, Columbus, OH, 3Duke University Medical Center, Durham, NC, 4NIAMS, NIH, Bethesda, MD

    Background/Purpose: Juvenile-onset systemic lupus erythematosus (JSLE) is associated with chronic inflammation and increased risk of atherosclerosis. The APPLE trial was a randomised, placebo-controlled trial of…
  • Abstract Number: 007 • 2023 Pediatric Rheumatology Symposium

    Single Cell RNA Sequencing Analysis of the Skin to Evaluate the Effect of Autologous Stem Cell Transplant on Fibroblast Populations in Juvenile Onset Systemic Sclerosis

    Claire Cheng, Giffin Werner, Anwesha Sanyal and Kathryn Torok, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Juvenile systemic sclerosis (JSSc) is a rare autoimmune disease associated with high morbidity. Inflammatory driven multi-organ fibrosis is similar to adult-onset SSc, with 40%…
  • Abstract Number: 013 • 2023 Pediatric Rheumatology Symposium

    Applying Pathway Analysis to Whole Genome Data to Identify Pathophysiologic Pathways in Childhood-onset Systemic Lupus Erythematosus

    Katie Heitzman1, Luis Franco2, Linda Hiraki3, Earl Silverman3, Christiaan Scott4, Ana Barrera-Vargas5, Zuoming Deng2, Mariana Kaplan2 and Laura Lewandowski2, 1NIH, Bethesda, MD, 2NIAMS, NIH, Bethesda, MD, 3The Hospital for Sick Children, Toronto, ON, Canada, 4University of Cape Town, South Africa, 5Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disorder. The pathogenesis of SLE is not fully understood, but twin/sibling high concordance rate suggests…
  • Abstract Number: 014 • 2023 Pediatric Rheumatology Symposium

    Characterizing Lupus in African American Children in Southern United States

    Anita Dhanrajani1, Taylor Long1, Spencer Hagwood2, Leslie Johnson1 and Cynthia Karlson1, 1University of Mississipi Medical Center, Jackson, MS, 2University of Mississipi Medical Center School of Medicine, Jackson, MS

    Background/Purpose: African-American (AA) ethnicity is a known predisposing factor for childhood onset systemic lupus erythematosus (cSLE) and a predictor of poor outcomes. In addition to…
  • Abstract Number: 006 • 2023 Pediatric Rheumatology Symposium

    Implementation of Automated Depression Screening in Patients with Lupus in a Tertiary Pediatric Rheumatology Clinic

    Lauren Harper1, Alana Goldstein-Leever1, James Gallup1, Vidya Sivaraman2, Stacy Ardoin1, Kyla Driest1, Evan Mulvhihill3 and Alysha Taxter4, 1Nationwide Children's Hospital, Columbus, OH, 2Nationwide Children's Hospital/ The Ohio State University, Columbus, OH, 3Nemours Children's Hospital, 4Nationwide Children's Hospital, Columbus, OH

    Background/Purpose: Patients with chronic rheumatic conditions, particularly lupus, have higher rates of depression, which significantly impacts their lives and can lead to poor medication compliance…
  • Abstract Number: 001 • 2023 Pediatric Rheumatology Symposium

    Serious Infections Among Children with Systemic Lupus Erythematosus in the Pediatric Health Information System

    Jordan Roberts, Anna Faino, Mersine Bryan, Jonathan Cogen and Esi Morgan, Seattle Children's Hospital, Seattle, WA

    Background/Purpose: High rates of serious infection have beenreported in pediatric systemic lupus erythematosus (pSLE), but modern care practices including pneumococcal vaccination, changing corticosteroid use, and…
  • Abstract Number: 137 • 2023 Pediatric Rheumatology Symposium

    Geographic Mapping of Adolescents with Rheumatic Disease: Racial and Ethnic Diversity by Texas County

    Kristina Ciaglia1, Chan-hee Jo2, Yuhan Ma2, Tracey Wright3 and Lorien Nassi1, 1University of Texas Southwestern, Dallas, TX, 2Scottish Rite Hospital for Children, Dallas, TX, 3University of Texas Southwestern, Scottish Rite Hospital for Children, Dallas, TX

    Background/Purpose: Rheumatic disease disproportionately impacts specific racial and ethnic groups frequently, resulting in health care inequities. Health care disparities are prevalent within certain geographic areas…
  • Abstract Number: 015 • 2023 Pediatric Rheumatology Symposium

    Epigenetically-Distinct B Cell Profiles Pre- and Post-Induction Therapy in Pediatric Lupus

    Joyce Hui-Yuen1, Kaiyu Jiang2, Susan malkiel3, Betty Diamond4 and James Jarvis5, 1Cohen Children's Medical Center, Northwell Health, Lake Success, New York; Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, 2University at Buffalo, Buffalo, NY, 3Feinstein Institutes for Medical Research, Manhasset, NY, 4The Feinstein Institutes for Medical Research, Manhasset, NY, 5University at Buffalo Jacobs School of Medicine, Buffalo, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) may be triggered by gene-environment interactions. Data are scarce on how epigenetic variance contributes to disease risk in pediatric SLE…
  • Abstract Number: 008 • 2023 Pediatric Rheumatology Symposium

    Treatment Response and Outcomes of 63 Cases of Juvenile Dermatomyositis-Associated Calcinosis

    Belina Yi1, Dawn Wahezi2, Lauren Covert3, Kaveh Ardalan4, Joyce Hui-Yuen5, Natalia Vasquez Canizares2, Doaa Mosad Mosa6, Madison Jones7, Colleen Correll8, Alexis Begezda9, Susan Shenoi10, Eveline Wu11, Leonard Kovalick12, William Lapin13, Stacey Tarvin14, Melissa Oliver15, Martha Rodriguez14, Itay Marmor16, Kevin Baszis17, Alysha Taxter18, Andrew Hanson19, Cynthia Crowson19 and Amir Orandi19, 1Children's Hospital Los Angeles, Los Angeles, CA, 2Children's Hospital at Montefiore, New York, NY, 3Duke University, Durham, NC, 4Duke University School of Medicine, Durham, NC, 5Cohen Children's Medical Center, Northwell Health, Lake Success, New York; Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, 6Mansoura University Hospitals, Mansoura University Faculty of Medicine, El Mansoura, Egypt, 7Keck School of Medicine at University of Southern California, Los Angeles, CCA, 8University of Minnesota, Minneapolis, MN, 9Penn State, State College, PA, 10Seattle Children's Hospital, Seattle, WA, 11UNC Chapel Hill, Chapel Hill, NC, 12UNC Health Care, Durham, NC, 13Connecticut Children's, Hartford, CT, 14Riley Hospital for Children at Indiana University Health, Indianapolis, IN, 15Indiana University, Indianapolis, IN, 16Dana-Dwek Children's Hospital, Hod Hasharon, Israel, 17Washington University School of Medicine, St Louis, MO, 18Nationwide Children's Hospital, Columbus, OH, 19Mayo Clinic, Rochester, MN

    Background/Purpose: Calcinosis is a poorly understood and morbid complication of juvenile dermatomyositis (JDM). As there is no consensus treatment approach for calcinosis, and limited knowledge…
  • Abstract Number: 010 • 2023 Pediatric Rheumatology Symposium

    Remotely Delivered Psychological Intervention May Be Beneficial to Youth with Childhood-Onset Lupus: A Preliminary Investigation

    Natoshia Cunningham1, Michelle Adler2, Ashley Danguecan3, Mallet Reid2, Samantha Ely4, Mathew Reeves2, Lawrence Ng3, Paris Moaf3, Sarah Mossad3, Tala El Tal3, Luana Flores Pereira3, Deborah Levy3, Linda Hiraki3, Jennifer Stinson3, Sarah Ahola Kohut3, Khalid Abulaban5, Elizabeth Kessler5, Stacy Allen5, Tamar Rubinstein6, Evin Rothschild6, Natalie Rosenwasser7, Kabita Nanda7, Susan Canny7, Emily Smitherman8, Livie Huie8, James Birmingham9, Allison Thompson10, Janel Thompson10, Miranda Moyer10, Emily Nguyen10, Angela Chapson10 and Andrea Knight3, 1Michigan State University, Grand Rapids, MI, 2Michigan State University, East Lansing, 3The Hospital for Sick Children, Toronto, ON, Canada, 4Wayne State University, Michigan State University, Detroit, MI, 5Helen DeVos Children's Hospital, Grand Rapids, MI, 6Children's Hospital at Montefiore, New York, NY, 7Seattle Children's Hospital, Seattle, WA, 8University of Alabama at Birmingham, Birmingham, AL, 9Metro Health, Cleveland, 10Patient Co-Investigative Team

    Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is associated with fatigue, pain, and depressive symptoms that adversely impact health-related quality of life. The Treatment and Education…
  • Abstract Number: 004 • 2023 Pediatric Rheumatology Symposium

    Analysis of Patients with Juvenile Dermatomyositis Compared to Healthy Controls Using CITE-seq Identifies Differences in Cell Composition and Gene and Epitope Expression

    Camilla Wibrand1, Emily Flynn2, Gabrielle Rabadam2, George Hartoularos2, Yang Sun2, Chun Ye2, Susan Kim3, Marina Sirota2 and Jessica Neely1, 1UCSF, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3UCSF Benioff Children's Hospital, San Francisco, CA

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare and serious systemic autoimmune condition, and much remains unknown about the pathogenesis, the immune cell types and cell-specific…
  • Abstract Number: 005 • 2023 Pediatric Rheumatology Symposium

    Real-World Application of the Pediatric Glucocorticoid Toxicity Index in Children with Lupus Nephritis: A Feasibility and Initial Validation Study

    Emily Zhang1, Gabrielle Alonzi1, Madeline Hlobik1, Esra Meidan1, Mindy Lo1, Olha Halyabar2, Melissa Hazen1, Ezra Cohen3, Lauren Henderson1, Siobhan Case4, Margaret Chang1, Camille Frank1, Ankana Daga1, Jonathan Hausmann5, Ahmad Bakhsh1, Liyoung Kim1, Daniel Ibanez1, Holly Wobma1, Mia Chandler6, Fatma Dedeoglu1, Robert Sundel1, Peter Nigrovic1, Karen Costenbader7, Mary Beth Son1 and Joyce Chang1, 1Boston Children's Hospital, Boston, MA, 2Children's Hospital/Boston Medical Center, Boston, MA, 3Boston Medical Center, Boston, MA, 4Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA, 5Boston Children's Hospital / Massachusetts General Hospital, Boston, MA, 6Boston Children's Hospital; Brigham and Women's Hospital, Boston, MA, 7Brigham and Women's Hospital/ Harvard Medical School, Boston, MA

    Background/Purpose: The morbidity of chronic glucocorticoid (GC) use is rarely captured as a standardized clinical outcome in pediatric rheumatic conditions. The newly developed pediatric glucocorticoid…
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