Serum 25(OH)D Levels in Adolescents and Young Adults with Juvenile Idiopathic Arthritis and Juvenile Onset Systemic Lupus Erythematosus: Prevalence and Association with Disease Activity

Fernanda Falcini¹, Stefano Stagi², Loredana Cavalli³, Giulia Carnesecchi¹, Federico Bertini¹, Laura Masi³, Marco Matucci-Cerinic¹ and Maria Luisa Brandi³, ¹Department of Internal Medicine, Rheumatology Section, Transition Clinic, University of Florence, Florence, Italy, ²Pediatric Endocrinology Unit, Anna Meyer Children’s Hospital, University of Florence, Firenze, Italy, ³Department of Internal Medicine, Endocrinology Unit, University of Florence, Firenze, Italy

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: 25 OH D Vitamin insufficiency, juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE)

Session Information

Title: Pediatric Rheumatology - Clinical and Therapeutic Aspects: Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Diseases

Session Type: Abstract Submissions (ACR)

Background/Purpose: Numerous data are available in literature on 25 (OH)D serum levels in general population, few and contradictory in Juvenile Idiopathic Arthritis (JIA), and scarce in Juvenile onset Systemic Lupus Erythematosus (JSLE) pts. Our goals are:1- to evaluate the serum 25(OH)D status in a large cohort of JIA and JSLE pts; 2- to correlate the 25(OH)D levels with the variables associated with JIA and JSLE. 3.To compare the pts results with healthy controls.

Methods: 144 JIA pts (122 F, 22 M, median age 15.5 ± 7.2 yrs: 78 oligo, 30 poly, 12 systemic and 24 Entesitis-arthritis [ERA]) onsets, and 46 JSLE pts (38 F, 8M, median age 16.9 ± 6.8 yrs) were studied after informed consent and Ethical approval. In all, serum 25( OH)D, serum intact parathyroid hormone (PTH), calcium, phosphorus, and bone alkaline phosphatase were measured. 100 sex-matched healthy subjects acted as controls.

Results: No significant difference of 25(OH)D levels has been detected in JIA and JSLE pts in comparison to controls as regard the percentage of those with VD deficiency and insufficiency. Of note, in JIA and JSLE pts with deficiency or insufficiency, a significant difference in comparison to controls with deficit or insufficiency, as regard the percentage of subjects with increased PTH and alkaline bone phosphatase levels (p < 0.0001) was detected. In addition, among 25(OH)D levels and JIA subtypes, the lowest levels were found in systemic and poly than in oligo and ERA onsets. Moreover, systmic and poly pts have a significant lower increase of 25 (OH)D levels after supplementation than oligo, ERA pts, and controls with a high percentage of those who remains with insufficiency (p < 0.001). The same results have been observed in JSLE pts who showed a high percentage of insufficiency, despite supplementation, of 25(OH)D than controls. The persistent low 25 (OH)D levels, despite supplementation, are significantly higher in patients with persistent active disease.

Conclusion: Serum 25 (OH) D levels and the percentage with persistent VD insufficiency seem to correlate to type of disease and disease activity. These preliminary results suggest a higher consumption and a higher request of 25(OH)D in patients with active JIA and JSLE.

Disclosure:

F. Falcini,
None;

S. Stagi,
None;

L. Cavalli,
None;

G. Carnesecchi,
None;

F. Bertini,
None;

L. Masi,
None;

M. Matucci-Cerinic,
None;

M. L. Brandi,
None.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-25ohd-levels-in-adolescents-and-young-adults-with-juvenile-idiopathic-arthritis-and-juvenile-onset-systemic-lupus-erythematosus-prevalence-and-association-with-disease-activity/