ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2047

No Association of Serum Uric Acid with Hip Fracture Risk in Older Men and Women from the Framingham Original Cohort

Shivani Sahni1, Kelsey Mangano2, Katherine Tucker3, Caroline Fox4, Douglas P. Kiel5, Xiaochun Zhang6 and Marian T. Hannan1, 1Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Musculoskeletal Research, Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Clinical Laboratory & Nutritional Sciences, Center for Population Health & Health Disparities, University of Massachusetts, Lowell, MA, 4Institute of Genetics and Biophysics, NHLBI's Framingham Heart Study and Center for Population Studies, Framingham, MA, 5Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 6Musculoskeletal Research, Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: , , ,

Session Information

Title: Epidemiology and Public Health (ARHP)

Session Type: Abstract Submissions (ARHP)

Background/Purpose:   Serum uric acid (UA) has been linked with fractures in older men. Three different studies in older men showed conflicting results. The objective of this study was to examine the association of UA with hip fracture risk over 19.9y follow-up in men and women from the Framingham Original Cohort. 

Methods:  2,969 men & women had measured UA concentration (mg/dl) at baseline (1973-76) and were followed for hip fracture until 2009. We used Cox-proportional hazards regression to estimate Hazard Ratios (HR) adjusting for age, sex and menopausal status (men, pre- and post-menopausal women), weight and height. An interaction between UA and sex was tested. Analysis was conducted on a combined sample of men and women, if the interaction term was not significant (P>0.05).

Results:  The mean age was 66y (SD: 7.7, range: 53-85). 368 hip fractures occurred over the follow-up (mean of 19.9 years). The mean ± SD (mg/dl) uric acid at baseline was: 5.3 ± 1.4. Interaction between UA and sex was not statistically significant (P=0.72); therefore, men and women were analyzed together. An increase in one unit of UA was associated with a 7% decrease in hip fracture risk in the crude model [HR(95%CI): 0.93 (0.86-1.0); P=0.048]. Similar associations were observed when UA was analyzed as tertile categories (P-trend: 0.08). Participants in the highest tertile of UA [HR (95%CI):0.79 (0.61-1.03)] tended to have lower risk of hip fracture than those in the lowest tertile (P=0.08).These associations became non-significant after adjustment for covariates.

Conclusion: These results suggest that serum UA is not a risk factor for hip fracture risk in older adults. 

Table. Association of serum uric acid (mg/dl) with risk of hip fracture in men and women. 

 

N

HR(95% CI)

P-value

Crude

2,969

0.93(0.86,1.0)

0.048*

Adjusted1

2,966

1.01(0.93,1.1)

0.850

1Adjusted for: age, sex and menopausal status (men, pre-menopausal women, post-menopausal women), height and weight, *P<0.05.

Funding support: The ASBMR JFOR201314 Award, NIH/NIAMS R03 AR 062808, NIH AR # 053205; FHS N01-HC-25195 R01 AR/AG 41398

Disclosure:

S. Sahni,
None;

K. Mangano,
None;

K. Tucker,
None;

C. Fox,
None;

D. P. Kiel,

Springer for editorial work and author royalties from UpToDate®.,

7,

Institutional grants from Merck Sharp and Dohme, Amgen, Eli Lilly ,

2,

Merck Sharp and Dohme, Amgen, Eli Lilly, Ammonett Pharma and Novartis,

9;

X. Zhang,
None;

M. T. Hannan,
None.

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