ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 639

Examination Of The Cytokine Profile Of The Cerebrospinal Fluid In Neuropsychiatric Systemic Lupus Erythematosus

Kunihiro Ichinose1, Takeshi Ushigusa2, Yoshikazu Nakashima3, Takahisa Suzuki3, Yoshiro Horai4, Shin-ya Kawashiri2, Naoki Iwamoto2, Mami Tamai3, Kazuhiko Arima4, Hideki Nakamura2, Tomoki Origuchi5 and Atsushi Kawakami4, 1Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: , , ,

Session Information

Title: Systemic Lupus Erythematosus - Human Etiology and Pathogenesis: Mechanisms and Biomarkers

Session Type: Abstract Submissions (ACR)

Examination of the cytokine profile of the cerebrospinal fluid in neuropsychiatric systemic lupus erythematosus

Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in systemic lupus erythematosus (SLE). NPSLE syndromes involve both the central and peripheral nervous systems. Despite advances in the understanding of the immunopathogenic and clinical aspects of SLE, NPSLE remains a diagnostic and therapeutic challenge.

Methods: We examined the cytokine profile in the cerebrospinal fluid (CSF) of NPSLE patients admitted to our hospital in a 7-year period from 2006 through 2012 and searched for markers that may be useful for the diagnosis of NPSLE. We used the CSF of patients with multiple sclerosis (MS) or neuromyelitis optica (NMO) as a disease control group. We examined 27 types of cytokine, chemokines, and growth factors in the NPSLE group (n=27), MS group (n=10) and NMO group (n=10) using Bio-Plex Pro assays.

Results: All of the NPSLE patients were women. The mean ± SD disease duration of NPSLE was 10.6±9.56 years. The NPSLE patients’ Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) score was 13.3±5.86, and their anti-ds-DNA antibody level was 23.3±58.6 U/mL. The percentages of anti-phospholipid antibody syndrome, anti-ribosomal P antibody positivity, and abnormality of brain MRI were 4/27 (14.8%), 5/27 (18.5%) and 9/27 (33.3%), respectively. Aside from the cytokines that are known to be related to NPSLE such as interleukin (IL)-6, the concentrations of basic FGF, and IL-1ra, -5, -7, -9, -15 and -17 were significantly higher in the NPSLE group compared to the other two groups. A multivariate analysis revealed that the protein levels of IL-5 (p<0.036), IL-9 (p<0.0005), IL-15 (

Conclusion: In NPSLE patients who do not show IL-6 elevation, it might be advisable to examine other cytokines. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease.

Disclosure:

K. Ichinose,
None;

T. Ushigusa,
None;

Y. Nakashima,
None;

T. Suzuki,
None;

Y. Horai,
None;

S. Y. Kawashiri,
None;

N. Iwamoto,
None;

M. Tamai,
None;

K. Arima,
None;

H. Nakamura,
None;

T. Origuchi,
None;

A. Kawakami,
None.

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