ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2029

Iron Deficiency in Familial Mediterranean Fever: A Study on 211 Adult Patients from the JIR Cohort

Ilenia Di Cola1, Lea Savey2, Marion Delplanque3, Rim bourguiba3, Alessandra Bartoli4, Zohra Aknouche3, Fatima Bensalek3, Isabelle Kone Paut5, Linda Rossi Semerano5, Isabelle Melki6, Brigitte Bader-Meunier7, Bénédicte Neven6, PIERRE QUARTIER8, Guilaine Boursier9, Irina Giurgea10, Laurence Cuisset11, Gilles Grateau3, Veronique Hentgen12 and Sophie Georgin-lavialle13, 1University of L'Aquila, L'Aquila, Italy, 2Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, france, France, 3Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, Paris, France, 4Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, italy, Italy, 5Kremlin Bicêtre hospital, Le Kremlin Bicêtre, France, 6Necker Hospital, Paris, France, 7Necker Hospital, Assistance Publique Hopitaux de Paris, Paris, France, 8Université Paris-Cite, IMAGINE Institute, Necker Children’s Hospital, Paris Cedex 15, France, 9University of Montpellier, Montpellier, 10Trousseau hospital, Paris, France, 11Cochin hospital, Paris, France, 12Laboratoire de Génétique des Maladies Rares et Autoinflammatoires, Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, CEREMAIA, CHU de Montpellier, Univ Montpellier, Montpellier, France, Le Chesnay, France, 13Sorbonne Université, Department of internal medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

Meeting: ACR Convergence 2024

Keywords: , ,

Session Information

Date: Monday, November 18, 2024

Title: Miscellaneous Rheumatic & Inflammatory Diseases Poster III

Session Type: Poster Session C

Session Time: 10:30AM-12:30PM

Background/Purpose: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. Fatigue is known to trigger FMF attacks. So far, no association has been reported iron deficiency and fatigue in FMF patients. Our aim was to evaluate the prevalence of iron deficiency in FMF patients and its association with clinical features, laboratory parameters, disease activity and outcomes over time.

Methods: A retrospective evaluation of prospectively followed FMF patients at the French National Reference Centre displaying two pathogenic exon 10 MEFV mutations was performed.

Results: Of 211 patients, 67 (31.8%) had a serum ferritin level < 27 ng/mL and were defined as iron deficient. Of these, 61 (91.0%) were female with a mean age of 36.81 (± 17.03) years. Among the 67 patients with iron deficiency, 132 (62.6%) displayed anemia (Hb < 13.0 g/dL). FMF patients with iron deficiency had lower Hb (p < 0.001) and BMI (p=0.023) and were significantly younger than those without iron deficiency (p=0.004), but they did not have more elevated inflammatory biomarkers. Female gender (p=0.0015) was associated with lower ferritin levels.

Conclusion: Iron deficiency, which mainly affects young women regardless of their level of inflammation, may be secondary to excessive gynaecological losses. Iron-deficient FMF patients may be more tired, which may lead to an increase in FMF attacks. Thus, it may be important to correct iron deficiency because this condition alone can cause asthenia, even in the absence of anemia. Interestingly, ferritin doesn’t seem to have pro-inflammatory properties in FMF. In conclusion, this work highlights the importance of measuring ferritin levels in FMF patients to detect iron deficiency in the absence of anemia.

Disclosures: I. Di Cola: None; L. Savey: None; M. Delplanque: None; R. bourguiba: None; A. Bartoli: None; Z. Aknouche: None; F. Bensalek: None; I. Kone Paut: None; L. Rossi Semerano: None; I. Melki: None; B. Bader-Meunier: None; B. Neven: None; P. QUARTIER: Abbvie, 2, 5, 6, BMS, 2, 5, 6, Chugai-Roche, 2, 5, 6, Novartis, 2, 5, 6, Pfizer, 2, 5, 6, Sweedish Orphan Biovitrum, 2, 5, 6; G. Boursier: None; I. Giurgea: None; L. Cuisset: None; G. Grateau: None; V. Hentgen: None; S. Georgin-lavialle: None.

To cite this abstract in AMA style:

Di Cola I, Savey L, Delplanque M, bourguiba R, Bartoli A, Aknouche Z, Bensalek F, Kone Paut I, Rossi Semerano L, Melki I, Bader-Meunier B, Neven B, QUARTIER P, Boursier G, Giurgea I, Cuisset L, Grateau G, Hentgen V, Georgin-lavialle S. Iron Deficiency in Familial Mediterranean Fever: A Study on 211 Adult Patients from the JIR Cohort [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/iron-deficiency-in-familial-mediterranean-fever-a-study-on-211-adult-patients-from-the-jir-cohort/. Accessed .

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