ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0411

Axial Radiographic Structural Damage in Enthesitis-Related Arthritis in Children and Young Adult Patients

Annelyse de Araújo Pereira1, Marcelo Pinheiro2, Jade Dib Fernandez1, Ana Sakamoto3, Adham do Amaral e Castro1 and Maria Teresa Terreri4, 1UNIFESP-EPM, São Paulo, SP, Brazil, 2UNIFESP/ EPM, São Paulo, SP, Brazil, 3Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, 4UNIFESP, São Paulo, SP, Brazil

Meeting: ACR Convergence 2024

Keywords: , ,

Session Information

Date: Saturday, November 16, 2024

Title: Pediatric Rheumatology – Clinical Poster I

Session Type: Poster Session A

Session Time: 10:30AM-12:30PM

Background/Purpose: Enthesitis-related arthritis (ERA), a distinct subtype of juvenile idiopathic arthritis (JIA) related to HLA-B27 status and peripheral and axial involvement, presents with insidious onset of arthritis and/or enthesitis. However, there is a lack of data concerning axial new bone formation in patients transitioning into adulthood. This study aimed to bridge this gap by evaluating axial radiographic structural damage (axRxSD), encompassing the sacroiliac joints (SIJ), hips, and spine, in ERA patients across various age groups.

Methods: A cross-sectional cohort study was conducted with ERA patients aged up to 35 years.  Specific tools were used for measuring: disease activity (BASDAI, ASDAS), function (BASFI, HAQ-S), mobility (BASMI), clinical enthesitis (MASES), axRxSD including mSASSS for spine, Kellgren-Lawrence for hips, and modified New York criteria for SIJ, and ultrasound for enthesis evaluation (MASEI).

Results: A total of 26 ERA patients were included, of whom 76.9% were males, with a mean age at diagnosis and evaluation of 11.9 and 19.7 years, respectively. Current active arthritis and enthesitis were present in 19.2% and 23%, respectively, with a mean MASEI score of 12 (interquartile range: 6-17). Peripheral joint limitation was observed in 50% of the patients, despite a BASMI score of 2.2, and a 16% occurrence of abnormal Fabere’s test. Most of them (73.1%) fulfilled the modified New York criteria, but only 15.4% had radiographic hip involvement. Spine involvement, measured by mSASSS, was low (interquartile range: 0-4.2), with only two patients exhibiting syndesmophytes. Significant association was found only between axRxSD and BASMI (p=0.003).

Conclusion: Our results showed a high frequency of SIJ ankylosis along with less radiographic involvement in the spine and hips, suggesting a distinct structural damage phenotype among children compared to adults.

Disclosures: A. de Araújo Pereira: None; M. Pinheiro: None; J. Dib Fernandez: None; A. Sakamoto: None; A. do Amaral e Castro: None; M. Terreri: None.

To cite this abstract in AMA style:

de Araújo Pereira A, Pinheiro M, Dib Fernandez J, Sakamoto A, do Amaral e Castro A, Terreri M. Axial Radiographic Structural Damage in Enthesitis-Related Arthritis in Children and Young Adult Patients [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/axial-radiographic-structural-damage-in-enthesitis-related-arthritis-in-children-and-young-adult-patients/. Accessed .

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/axial-radiographic-structural-damage-in-enthesitis-related-arthritis-in-children-and-young-adult-patients/