Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: To examine geographic variations of gout prevalence, incidence and management in the United Kingdom.
Methods: We used the Clinical Practice Research Data-link (CPRD) to estimate the prevalence, incidence of gout, consultation rate for gout, percentage under urate-lowering treatment (ULT) and time to first prescription of ULT in each of 13 areas in the United Kingdom: North East, North West, Yorkshire & The Humber, East Midlands, West Midlands, East of England, South West, South Central, London, South East Coast, Northern Ireland, Scotland and Wales.
Results: Overall prevalence of gout was 2.51% (95% CI, 2.50%‒2.52%) and incidence was 1.87 (95% CI, 1.83‒1.91) per 1000 person-years in the UK in 2012. The prevalence and incidence vary throughout the country (Figure 1). The highest prevalence was in North East (3.11% [3.00%‒3.23%]) and Wales (2.98% [2.93‒3.03]); the highest incidence as also in these 2 regions (2.30 [95% CI, 2.26‒2.35] and 2.20 [95% CI, 2.15‒2.24] per 1,000 patient-years respectively). Among prevalent gout patients in 2012, only 50,453 patients (43.6%) were under medical attention (with at least one consultation with a gout diagnosis or a prescription containing ULT). Management of gout in terms of percentage given ULT also varies between regions, partially in line with the variation of prevalence (Table 1). In general only one-third of prevalent cases were given ULT, and only one quarter of incident cases received ULT within one year from diagnosis.
Conclusion: A regional variation of gout prevalence and incidence in the UK was observed. Only a minority of people with gout receive ULT and this aspect of gout management also varied between regions, suggesting a need for further education of general practitioners with respect to understanding of gout and its mangement.
Figure 1. Geographic variations in the prevalence and incidence of gout
Table 1. Regional variation in gout management of gout in the United Kingdom in 2012
|
Area |
Prevalent cases |
Incident cases |
||
|
Consulted |
Treated by ULT |
ULT by 6 months |
ULT by 12 months |
|
|
Overall |
43.8% |
31.1% |
16.1% |
23.3% |
|
North East |
36.4% |
37.7% |
16.6% |
20.2% |
|
North West |
43.2% |
31.8% |
19.2% |
26.7% |
|
Yorkshire & The Humber |
39.0% |
24.9% |
8.6% |
16.0% |
|
East Midlands |
44.5% |
25.7% |
6.6% |
10.3% |
|
West Midlands |
38.2% |
27.5% |
14.4% |
20.6% |
|
East of England |
44.1% |
32.3% |
14.7% |
21.8% |
|
South West |
37.1% |
29.6% |
11.4% |
18.3% |
|
South Central |
44.2% |
26.0% |
12.6% |
17.9% |
|
London |
43.9% |
35.1% |
18.0% |
28.0% |
|
South East Coast |
37.7% |
30.6% |
17.0% |
23.9% |
|
Northern Ireland |
46.7% |
29.3% |
18.0% |
24.7% |
|
Scotland |
65.9% |
37.8% |
22.1% |
30.1% |
|
Wales |
44.7% |
30.7% |
15.1% |
21.1% |
Disclosure:
C. F. Kuo,
None;
M. Doherty,
None;
M. J. Grainge,
None;
W. Zhang,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/geographic-variations-of-gout-epidemiology-in-the-united-kingdom-a-nationwide-population-study/