Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The purpose of this study was to: (1) Explore and test Cognitive Performance Score (CPS) in systemic lupus erythematosus (SLE) and (2) Compare different CPS scores between SLE and controls and to determine if there is a difference according to patientsage.

Methods: Consecutive SLE and healthy controls completed to the PedAnam. We performed the calculation of four scores: (1) PedANAM-CPSUWA using unweighted averages of the accuracy score; (2) PedANAM-CPSPCA principal component analysis; (3) PedANAM-CPSlogit used logistic regression; (4)PedANAM-CPSmultiscore logistic models based on performance parameters with selected subtests. After these calculations, we observed the correlation between the CPS indices and compared the performance of patients and healthy controls. Cognitive impairment was determined by z-scores and considered present if ≤2 SD from healthy controls.

Results: We included a total of 201 consecutive SLE (183 [48.4%] women; median age = 28 years; age range = 9–76 years) and 177 healthy controls (124 [32.8 %] women; median age = 22; age range = 9-60 years). We observed a correlation between the PedANAM-CPSUWA and the PedANAM-CPSPCA (r = 0.99), PedANAM-CPSPCA and PedANAM-CPSmultiscore (r = -0.60) logit and PedANAM-CPSUWA (r = -0.56). We observed statistically significant differences between patients and healthy controls in the PedANAM-CPSUWA and PedANAM-CPSPCA scores (P = 0.001). The PedANAM-CPSlogit and PedANAM-CPSmultiscore indices did not show significant differences between groups. Furthermore, separating SLE according to current age ( < 18 years and ≥18 years), no difference between the four indices was noted. Cognitive impairment was observed in 16.42% SLE patients and 4.52% healthy controls (p < 0.001) by the PedANAM-CPSUWA index and in 17.91% SLE patients and 5.64% healthy controls (p < 0.001) using the PedANAM-CPSPCA index.

Conclusion: After the translation and validation process, this is the first study using the CPS in Brazilian version of PedANAM. Two of the metrics were able to differentiate between SLE and healthy controls. No difference according to current age was observed.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/cognitive-performance-score-of-the-pediatric-automated-neuropsychological-assessment-metrics-software-in-a-brazilian-cohort/