Background/Purpose: The etiology and pathogenesis of Behçet’s disease (BD) are not yet well understood, but immunoregulatory abnormalities have been proposed as pathogenic mechanisms. Ischemia-modified albumin (IMA) is increased in diseases associated with oxidative stress, which plays an important role in the development of Behçet’s disease.To investigate oxidative status and IMA levels in patients with Behçet’s disease and their association with clinical and laboratory parameters

Methods:

Thirty-five patients with Behçet’s disease and 31 healthy controls matched for age and gender were enrolled. Patients’ clinical and demographic characteristics were recorded. Serum IMA, malondialdehyde (MDA), total antioxidative status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) levels were then evaluated.

Results:

Serum IMA, MDA, TOS and OSI levels were significantly higher in patients with Behçet’s disease than in the healthy control group. Serum TAS was significantly lower in patients with Behçet’s disease than in the healthy controls. There was a statistically significant positive correlation between IMA levels and MDA, TOS, erythrocyte sedimentation rate and C-reactive protein levels. IMA levels were statistically significantly higher in patients with vascular involvement (p=0.016).

Conclusion: Our results demonstrate increased oxidative stress and decreased antioxidant capacity in patients with Behçet’s disease. IMA levels were higher in patients with Behçet’s disease than in healthy controls. IMA may be produced through an adaptive response to chronic hypoxia and oxidative stress, which may play a role in the systemic inflammation seen in Behçet’s disease. IMA can be a useful guiding marker, particularly in patients with vascular involvement.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/ischemia-modified-albumin-a-novel-marker-of-vascular-involvement-in-behcets-disease/