Background/Purpose: Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains the basis of LN diagnosis . There is urgent need to identify biomarkers that alternative to renal pathology in lupus.
Aim :To study urinary angiostatin in SLE and investigate their possible role as indicative of renal involvement to be used as alternative to biopsy .
Methods: Angiostatin levels were measured in urine samples from 45 lupus patients and 14 healthy volunteers, renal biopsy was obtained from all patients
Results: SLE patients had elevated urinary angiostatin as compared to controls (P < 0.001). Levels of urinary angiostatin were higher in patients with an active LN (lupus nephritis ) than those with inactive LN (P < 0.001). In patients with LN urinary angiostatin correlated with the renal score of the Systemic Lupus Erythematosus Disease Activity Index. Urinary angiostatin levels varied significantly and there is significant positive correlation (P <0.05) levels with the activity and choronicty scores of the examined renal biopsies among the histopathological groups.
Conclusion: Urinary angiostatin is potentially useful markers of lupus activity. urinary angiostatin able to differentiate patients with active SLE from those with inactive disease .urinary levels are indicative of renal activity. Patients with Class IV lupus nephritis exhibited the highest levels of urinary angiostatin.Urinary angiostatin can be used as non invasive marker to detect renal involvement in lupus nephritis alternative to renal biopsy
Disclosure:
S. Algergawy,
None;
O. Alshaar,
None;
R. Zakaria,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/urinary-angiostatin-as-alternative-to-biopsy-in-lupus-nephritis-patients-among-egyptian/