ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1276

Myositis Specific Antibodies and Clinical Features in Patients from Argentina

Amelia Granel1, Maria de Los Angeles Gargiulo 2, Ana Carolina Marcos 3, Ramiro Gomez 4, Andrea Braillard Poccard 5, Carolina Costi 6, Mercedes Garcia 7, Malena Viola 8, Maria de la Vega 9, Belen Barrios 10, Silvia Papasidero 11, Boris Kisluk 12, Guillermo Berbotto 12, Mariana Aciar 13, María Crespo Espíndola 14, Mariano Rivero 15, Maria N Lojo 16, Yessica Ponce Delgado 17, Oscar Rillo 18, Ramiro Puerta 19, Isabel Pineda 20, Dafne Capelusnik 21, Roberto Movia 22, Darío Scublinsky 23, Maria Alicia Lazaro 24 and Graciela Gómez 25, 1Hospital San Roque,Gonnet,La Plata,Buenos Aires.Argentina, La Plata, Buenos Aires, Argentina, 2Instituto de Investigaciones Médicas,Alfredo Lanari.Universidad de Buenos Aires.Argentina, Ciudad de Buenos Aires, Argentina, 3Hospital San Roque,Gonnet,La Plata,Buenos Aires.Argentina, Gonnet, Argentina, 4Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 5Hospital de Clínicas José de San Martin, Buenos Aires, Buenos Aires, Argentina, 6Hospital General “San Martín” de la Plata, La Plata, Buenos Aires, Argentina, 7Hospital San Martín, La Plata, Argentina, 8Centro Reumatologia DOM, Buenos Aires, Buenos Aires, Argentina, 9CEIM Investigaciones Medicas, Buenos Aires, Argentina, 10Hospital Enrique Tornu,Ciudad de Buenos Aires.Argentina, Ciudad de Buenos Aires, Argentina, 11Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 12Hospital Escuela Eva Perón.Granadero Baigorria,Santa Fe.Argentina, Granadero Baigorria, Argentina, 13Hospital Ntro Señor del Milagro, Salta.Argentina., Salta, Argentina, 14Hospital Señor del Milagro, Salta, Salta, Argentina, 15Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 16Hospital Rossi,La Plata.Argentina, La Plata, Argentina, 17Hospital Pirovano.Ciudad de Buenos Aires. Argentina, Ciudad de Buenos Aires, Argentina, 18Hospital Pirovano, Buenos Aires, 19Hospital Houssay.Vicente Lopez,Buenos Aires.Argentina., Vicente Lopez, Argentina, 20Consultorios Externos Venado Tuerto.Santa Fe.Argentina., Venado Tuerto, Argentina, 21Instituto de Rehabilitacion Psicofisica, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 22Hospital Evita.Lanus.Pcia Buenos Aires. Argentina, Lanus, Argentina, 23Centros Médicos Ambulatorios SMG, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 24Consultorio Particular, San Isidro, Argentina, 25Instituto de Investigaciones Médicas,Alfredo Lanari.Universidad de Buenos Aires.Argentina., Buenos Aires, Argentina

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: , , ,

Session Information

Date: Monday, November 11, 2019

Title: Muscle Biology, Myositis & Myopathies Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: To know the frequency of myositis specific antibodies (MSAs) and myositis associated antibodies( MAAs) and their relation with clinical features in patients with idiopathic inflammatory myopathy(IIM) from a Registry of Argentina.

Methods: Adults with IIM were enrolled in a retrospective way.Demographics,clinical and laboratory features were registered.Diagnosis of interstitial lung disease (ILD) was based on physician review of chest-x-ray, CT and/or pulmonary function tests.ANA were done in 291 patients, anti-Ro in 283, anti-Pm-Scl in 205,anti-Jo-1 in 263. MSAs against PL-12, PL-7, SRP and Mi-2 were done in 190 and anti: EJ, OJ, TIF1ϒ, MDA5, SAE, NXP2 ,Ku and Ro 52 were studied in 83 patients. These antibodies were detected by Immunoblot and ANA by IFI. Statistics: descriptive and Chi-squared.Stata v.11

Results: Were included 304 patients, 217(71%) women, mean age at diagnosis 46±15 years. Caucasian 42%, mestizos 37% and amerindios 8%. DM was described in 43%, PM 31,5%,IBM 1,6%, antisynthetase syndrome(ASS) in 18%, CADM 3,6%,IMNM 1,6%  and overlap myositis in 21,7%. Arthritis was present in 32%, RP 34% and ILD in  26,6%.
MAAs(+): ANA 62,5%, Ro 19% and Pm-Scl: 4,8%.
MSAs (+): Jo-1 16%, Mi-2 11%, SRP and Pl-7 2,6% each and Pl-12:1,5%. Other MSAs were studied in 83 patients: anti-MDA5 13,2%, TIF1ϒ 8,4%,  NXP2 3,6%,anti-SAE1,2%.Two patients had OJ and EJ.
Anti-Jo-1(+) was found in 37/41(90%) PM patients (p< 0,000), arthritis in 56% vs 31% in Jo-1(-) (p=0,005), ILD in 73% vs 15% Jo-1(-) (p< 0,000).
Anti-Mi-2 was found in 20/21 DM patients, 12 caucasians and 6 mestizos, none had ILD or anti Ro+ when were compared con Mi-2(-)  0% vs 27,3%(p=0,002) and 0% vs 26% (p=0,008),respectively, all Mi-2+ had increase CK value (100%) vs 78% Mi-2(-) p < 0,000.
The presence of MDA5 was associated with arthritis 72% vs 29%(p=0,01), ILD 63,6% vs 19,4% (p=0,005) and normal CK values 91% vs 16,6%(p< 0,000) when it was compared with patients without the antiboby. Anti Tif1 was present in 7/83 patients (8.4%),5 had DM and 2 had CADM, 1 patient had cancer.

Conclusion: Anti-Jo-1,anti-MDA5 and anti- Mi-2 were the most frequent MSAs found in our population, followed by anti- TIF1γ.
Anti-Mi-2 was present in DM while anti-Jo-1 was frequent in antisynthetasa syndrome with ILD and mainly in PM patients. 
Anti-MDA5 was seen in DM with normal CK and also related to ILD and arthritis.
All patients anti-Tif1γ positive had DM and only one had cancer.
There are differences in the frequency of MSAs probably related with ethnic background or geography but the clinical phenotypes remains similar.

Disclosure: A. Granel, None; M. Gargiulo, None; A. Marcos, None; R. Gomez, None; A. Braillard Poccard, None; C. Costi, None; M. Garcia, None; M. Viola, None; M. de la Vega, AbbVie, 8, BMS, 8, Janssen, 8, Lilly, 8, Pfizer, 5, 8, Raffo, 5, 8, Roche, 9, Sanofi, 5, 8; B. Barrios, None; S. Papasidero, None; B. Kisluk, None; G. Berbotto, None; M. Aciar, None; M. Crespo Espíndola, None; M. Rivero, None; M. Lojo, None; Y. Ponce Delgado, None; O. Rillo, None; R. Puerta, None; I. Pineda, None; D. Capelusnik, None; R. Movia, None; D. Scublinsky, None; M. Lazaro, None; G. Gómez, None.

To cite this abstract in AMA style:

Granel A, Gargiulo M, Marcos A, Gomez R, Braillard Poccard A, Costi C, Garcia M, Viola M, de la Vega M, Barrios B, Papasidero S, Kisluk B, Berbotto G, Aciar M, Crespo Espíndola M, Rivero M, Lojo M, Ponce Delgado Y, Rillo O, Puerta R, Pineda I, Capelusnik D, Movia R, Scublinsky D, Lazaro M, Gómez G. Myositis Specific Antibodies and Clinical Features in Patients from Argentina [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/myositis-specific-antibodies-and-clinical-features-in-patients-from-argentina/. Accessed .

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