ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 565

Evidence-Based Recommendations for the Management of Enteropathic Arthritis: A Rheumatology – Gastroenterology Collaborative Initiative

Gulen Hatemi 1, Servet Akar 2, Hale Akpinar 3, Pamir Atagunduz 4, Goksel Bengi 3, Gercek Can 5, Aykut Ferhat Celik 6, Sinem Nihal Esatoglu7, Onay Gercik 8, Hulya Hamzaoglu 9, Murat Inanc 10, Gokhan Kabacam 11, Ismail Hakki Kalkan 12, Levent Kilic 13, Fatos Onen 14, Ahmet Tezel 15, Murat Toruner 16 and Sedat Kiraz 13, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Behcet's Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, 2Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, 3Dokuz Eylul University, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Izmir, Turkey, 4Marmara University Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey, Istanbul, Turkey, 5Dokuz Eylul University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Izmir, Turkey, 6Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, 7Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 8Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, Izmir, Turkey, 9Acibadem University, Acibadem Fulya Hospital, Department of Gastroenterology, Istanbul, Turkey, 10Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 11Ankara Guven Hospital, Department of Gastroenterology, Ankara, Turkey, 12Türkiye Yüksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, Turkey, 13Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 14Dokuz Eylul University School of Medicine, Division of Rheumatology, İzmir, Turkey, 15Trakya University, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Edirne, Turkey, 16Ankara University School of Medicine, Department of Gastroenterology,, Ankara, Turkey

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, November 10, 2019

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Axial Spondyloarthritis, Clinical Features

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Management of enteropathic arthritis may be challenging due to differences in treatment response of inflammatory bowel diseases and arthritis to different therapeutic modalities, which may even cause worsening of some manifestations while improving others. Enteropathic arthritis was not addressed in the management recommendations for spondyloarthritis. The aim of this project was to develop a set of evidence based recommendations for the management of patients with enteropathic arthritis

Methods: A task force was formed that included ten rheumatologists and 8 gastroenterologists. Research questions were determined using a Delphi approach. A systematic literature search, data extraction, and statistical analyses were performed according to a pre-specified protocol. Studies that assessed the efficacy of an intervention on inflammatory bowel disease-related outcomes and/or spondyloarthritis related outcomes in patients with enteropathic arthritis were included. Risk ratios were calculated for binary outcomes and mean difference for continuous outcomes, whenever possible. Results of the systematic literature review were presented to the experts and recommendations were formulated after thorough discussions and voting.

Results: A total of 4 overarching principles and 10 recommendations were formulated. The recommendations addressed the use of NSAIDs, corticosteroids, sulfasalazine and 5-ASA derivatives, TNF inhibitors, tofacitinib, secukinumab, ustekinumab, and vedolizumab among patients with active inflammatory bowel disease, active arthritis, active disease regarding both inflammatory bowel disease and arthritis, and among patients in remission. Final voting showed a good agreement among the group on all recommendations.

Conclusion: These recommendations are intended to help rheumatologists, gastroenterologists and other clinicians dealing with enteropathic arthritis and to point out to the shortcomings of the available data on the management of this challenging condition.

Disclosure: G. Hatemi, Abbvie, Mustafa Nevzet, UCB, 8, Bayer, Eli Lilly, 5, BMS, Celgene Corporation, Silk Road Therapeutics, 2, Silk Road Therapeutics, 2; S. Akar, Abbvie, 2, 5, Amgen, 2, 5, MSD, 2, 5, Novartis, 2, 5, Pfizer, 2, 5, 8, Roche, 2, 5, UCB, 2, 5; H. Akpinar, None; P. Atagunduz, None; G. Bengi, None; G. Can, None; A. Celik, None; S. Esatoglu, None; O. Gercik, None; H. Hamzaoglu, None; M. Inanc, None; G. Kabacam, None; I. Kalkan, None; L. Kilic, None; F. Onen, Tofacitinib (Pfizer), 8; A. Tezel, None; M. Toruner, None; S. Kiraz, None.

To cite this abstract in AMA style:

Hatemi G, Akar S, Akpinar H, Atagunduz P, Bengi G, Can G, Celik A, Esatoglu S, Gercik O, Hamzaoglu H, Inanc M, Kabacam G, Kalkan I, Kilic L, Onen F, Tezel A, Toruner M, Kiraz S. Evidence-Based Recommendations for the Management of Enteropathic Arthritis: A Rheumatology – Gastroenterology Collaborative Initiative [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/evidence-based-recommendations-for-the-management-of-enteropathic-arthritis-a-rheumatology-gastroenterology-collaborative-initiative/. Accessed .

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