ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1613

Dactylitis in Early Spondyloarthritis. Baseline Data from a Prospective French National Cohort

Daniel Wendling1, Clément Prati2, Alain Saraux3, Anna Molto4, Thao Pham5, Maxime Dougados6 and Xavier Guillot7, 1Rheumatology, University Hospital - Bourgogne Franche Comté University, Besançon, France, 2Rheumatology, University Hospital - Bourgogne Franche Comté University, Besancon, France, 3Rheumatology, CHU Brest, Brest, France, 4Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 5Rheumatology Department, Aix-Marseille University, APHM, Marseille, France, 6Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 7PEPITE EA 4267, Bourgogne-Franche-Comté university, Besançon, France

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords:

Session Information

Date: Monday, October 22, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster II: Clinical/Epidemiology Studies

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Dactylitis is a particular feature shared across the several phenotypical forms of spondyloarthritis (SpA), part of the classification criteria. There are only few data available about impact of dactylitis in early stage of SpA, and factors associated with the presence/history of dactylitis.

Aim

To study, at baseline of the DESIR cohort the presence/history of dactylitis in an attempt to evaluate frequency of dactylitis in SpA and to look at the factors associated with presence of dactylitis.

Methods:

DESIR is a prospective observational cohort of patients with recent onset (less than 3 years) inflammatory back pain, beginning before 50 years, suggestive of axial SpA, All available factors in the database (clinical, biological, imaging and medico economic) were compared between patients with and without past or present dactylitis at baseline (for categorical variables : odds-ratio +/- 95% CI and chi-square/Fisher tests, for continuous variables : unpaired t-tests / Mann-Whitney) , by uni and then multivariate analysis(logistic regression). Significance: p less than 0.05.

Results:

At baseline, 708 patients were analyzed. 97 had a past history or a concomitant dactylitis [prevalence 13.7% (CI 95% : 11.6 – 16.2)]. Dactylitis occurred before axial symptoms in 41.3 % and before any other symptom in 14.1 % of the cases. By univariate analysis, dactylitis was significantly associated with history of arthritis, enthesitis, psoriasis, with elevated CRP and ESR, enthesitic and arthritis scores, BASDAI, ASDAS,BASFI, SF-36, HAQ, ASQoL, shorter disease duration, systemic and local steroids use, and with lower structural damage (sacro iliac, spine)

Table shows the result of the multivariate analysis.

item

OR

CI 95%

Arthritis history or presence

2.9

[11.2 – 30.9]

csDMARD use during the past 6 months

5.2

[2.9 – 9.1]

Calcaneal enthesitis history or presence

6.7

[3.0 – 14.7]

BASDAI > median

1.08

[1.05 – 1.11]

BASFI > median

1.04

[1.02 – 1.06]

SF36 phys <median

0.92

[0.87 – 0.97]

Systemic steroids during the past 6 months

5.49

[2.93 – 10.28]

Sacro iliac erosion (MRI central reading)

0.02

[0.004 – 0.13]

mSASSS (central reading )

0.37

[0.21 – 0.66]

Conclusion:

In the DESIR cohort of patients suspected for early SpA, history of dactylitis is present in 13.7 % of the cases at baseline. It is an early feature associated with peripheral involvement, and associated with more burden of the disease, more frequent use of DMARDs and steroids, but with less structural damage.

Disclosure: D. Wendling, None; C. Prati, None; A. Saraux, None; A. Molto, None; T. Pham, None; M. Dougados, None; X. Guillot, None.

To cite this abstract in AMA style:

Wendling D, Prati C, Saraux A, Molto A, Pham T, Dougados M, Guillot X. Dactylitis in Early Spondyloarthritis. Baseline Data from a Prospective French National Cohort [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/dactylitis-in-early-spondyloarthritis-baseline-data-from-a-prospective-french-national-cohort/. Accessed .

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/dactylitis-in-early-spondyloarthritis-baseline-data-from-a-prospective-french-national-cohort/