Trends in the Incidence of SOLID Tumors in Patients with Rheumatoid Arthritis in Spain. a National Observational Cohort Study

Virginia Villaverde García¹, Manuel Fernández², Ramon Mazzucchelli³, Cristina Macia-Villa⁴, Gloria Candelas⁵, Javier Quirós³, M Peña³, E Perez-Fernandez³, Natalia Crespí⁶, Alberto Garcia-Vadillo⁷, Carmen Barbadillo⁸, J.L Morell-Hita⁹, Hilda Godoy⁸, Maria Espinosa¹⁰, C Morado-Quiñoa⁵, Cristina Martinez-Prada⁵, María Galindo¹¹, O Guzon-Illescas³ and Angela Herranz¹², ¹Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain, ²Hospital Universitario de Guadalajara, Guadalajara, Spain, ³H.U.Fundación Alcorcón, Madrid, Spain, ⁴Hospital Universitario Severo Ochoa, Madrid, Spain, ⁵H.U. Clínico San Carlos, Madrid, Spain, ⁶C.S. La Rivota, Madrid, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸H.U. Puerta de Hierro, Madrid, Spain, ⁹H.U.Ramón y Cajal, Madrid, Spain, ¹⁰Rheumatology, H.U. Puerta de Hierro, Madrid, Spain, ¹¹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ¹²H.U. del Henares, Madrid, Spain

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Rheumatoid arthritis (RA)

Session Information

Date: Sunday, October 21, 2018

Title: Rheumatoid Arthritis – Diagnosis, Manifestations, and Outcomes Poster I: Comorbidities

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: During the last 20 years, the treatment in rheumatoid arthritis (RA) has changed. Considering the increasing use of biological immunomodulators to treat chronic inflammatory conditions and the concern that immunomodulation may alter cancer risk and progression, it’s important to know the tumors incidence in patients with RA. The objective of this study was to analyze the incidence and trend of hospital admissions for solid tumors in patients with RA in Spain during the period between 1999 and 2015.

Methods: This is a retrospective population based study. We have analized a national administrative database that includes a Minimum Basic Data Set (MBDS) of hospital admissions of RA patients during the period 1999 to 2015. We selected the MBDS for solid tumors (breast, colon, pancreas, prostate, lung, pleura, melanoma, ovary, cervix, uterus, bladder and kidney). Cases were identified by the presence in primary and secondary diagnosis of ICD 9 codes. The population at risk was estimated through the population census of the National Institute of Statistics, with an estimated prevalence of RA of 0,5% (0,8% in women and 0,2% in men). Crude and adjusted rates of the solid tumors were calculated, and the trend was analyzed using the Generalized Linear Model (GLM) with the year as the analysis variable.

Results:338.343 RA hospital admissions were detected in the study period, being 18.401 (5,4%) due to solid tumors. The main clinical-demographic characteristics are shown in the next table.

	Total	Women	Men	P value
N (%)	18.401 (5,4)	8689 (3,8)	9712 (8,6)	P<0,001
Age, mean (SD)	69,98 (11,21)	68,62 (12,3)	71,20 (9,99)	P<0,001
In-hospital exitus n (%)	2455 (13,34)	1035 (11,9)	1420 (14,62)	P<0,001
Charlson Index, mean (SD)	5,72 (2,95)	5,63 (2,95)	5,80 (2,95)	P<0,001
Stay, mean (SD)	10,94 (11,6)	10,76 (11,6)	11,1 (11,77)	P=0,051

The solid tumor adjusted rate during the study period was 647,53/10⁵ inhabitants/yr (366,97/10⁵ in women and 1792,99/10⁵ in men; relative risk men:women =4,8). This rate increased from 305,65/10⁵ in 1999 to 993,19/10⁵ inhabitants/yr in 2015 (814,06/10⁵ in 1999 to 2535,5/10⁵ in 2015 in men and from 181,68/10⁵ in 1999 to 607,71/10⁵ in 2015 in women). The annual age-adjusted rate increased significantly: 7,37% (6,52% in men and 8,02% in women; p≤0,001).

Figure 1.

Conclusion: There was an increasing incidence of hospital admissions due to solid tumors in RA in Spain during the period 1999-2015. An annual rate increase of 7.37%, is estimated.

Disclosure: V. Villaverde García, None; M. Fernández, None; R. Mazzucchelli, None; C. Macia-Villa, None; G. Candelas, None; J. Quirós, None; M. Peña, None; E. Perez-Fernandez, None; N. Crespí, None; A. Garcia-Vadillo, None; C. Barbadillo, None; J. L. Morell-Hita, None; H. Godoy, None; M. Espinosa, None; C. Morado-Quiñoa, None; C. Martinez-Prada, None; M. Galindo, None; O. Guzon-Illescas, None; A. Herranz, None.

To cite this abstract in AMA style:

Villaverde García V, Fernández M, Mazzucchelli R, Macia-Villa C, Candelas G, Quirós J, Peña M, Perez-Fernandez E, Crespí N, Garcia-Vadillo A, Barbadillo C, Morell-Hita JL, Godoy H, Espinosa M, Morado-Quiñoa C, Martinez-Prada C, Galindo M, Guzon-Illescas O, Herranz A. Trends in the Incidence of SOLID Tumors in Patients with Rheumatoid Arthritis in Spain. a National Observational Cohort Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/trends-in-the-incidence-of-solid-tumors-in-patients-with-rheumatoid-arthritis-in-spain-a-national-observational-cohort-study/. Accessed .

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