The Value of the Simplified Ramris-5 in Early RA Patients Under Methotrexate Therapy Using High Field MRI

Philipp Sewerin¹, Miriam Frenken², Daniel Benjamin Abrar², Christine Goertz³, Christoph Schleich⁴, Matthias Schneider⁵ and Benedikt Ostendorf¹, ¹Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Düsseldorf, Germany, ²Department for diagnostic and interventional Radiology, Heinrich-Heine-Universitiy, Duesseldorf, Germany, ³Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine-Universitiy, Duesseldorf, Germany, ⁴Department for diagnostic and interventional Radiology, Heinrich-Heine University, Duesseldorf, Germany, ⁵Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Imaging, MRI and rheumatoid arthritis (RA)

Session Information

Date: Sunday, October 21, 2018

Title: Imaging of Rheumatic Diseases Poster I: MRI

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) to five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthritis (RA) before and after the initiation of a methotrexate (MTX) therapy using high-resolution, 3 Tesla (T), magnetic resonance imaging (MRI).

Methods: 28 RA patients according to 2010 ACR/EULAR criteria (Ø 56.8 years (range 39 – 74), seropositive, disease duration < 6 months (range 2 – 23 weeks) were prospectively assessed with baseline investigation including clinical assessment (DAS-28 and CRP) and 3T MRI of the clinical dominant hand, as well as 3 and 6 months after starting MTX therapy. MRI-scans were analysed according to RAMRIS and the simplified RAMRIS-5 (Figure-1).

Results: DAS-28, CRP, RAMRIS and RAMRIS-5 decreased significantly after initiation of a MTX therapy. There was a strong correlation between RAMRIS-5 and RAMRIS at baseline (r=0.838; p=˂0.001) and follow-up (3 months: r=0.876; p= ˂0.001; 6 months: r=0.897; p=˂0.001).

Conclusion: 3T MRI based RAMRIS-5, a simplified and resource-saving RAMRIS score is a suitable tool to show changes in early RA and may be used for diagnosis and therapy monitoring in follow-up evaluations.

Figure1

Disclosure: P. Sewerin, None; M. Frenken, None; D. B. Abrar, None; C. Goertz, None; C. Schleich, None; M. Schneider, None; B. Ostendorf, None.

To cite this abstract in AMA style:

Sewerin P, Frenken M, Abrar DB, Goertz C, Schleich C, Schneider M, Ostendorf B. The Value of the Simplified Ramris-5 in Early RA Patients Under Methotrexate Therapy Using High Field MRI [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-value-of-the-simplified-ramris-5-in-early-ra-patients-under-methotrexate-therapy-using-high-field-mri/. Accessed .

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