ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1447

Smoking Reduces Efficacy of Biologics Differently By Target Cytokines in Rheumatoid Arthritis

Kentaro Kuzuya1, Yukihiko Saeki2, Jun Hashimoto3, Shirou Oshima4, Masato Matsushita5, Souichirou Tuji4, Yoshinori Harada6, Maiko Yoshimura6, Satoru Teshigawara6 and Hidetoshi Matsuoka4, 1Rheumatology and Allegology, Osaka-Minami Medical Ctr, Kawachinagano, Japan, 2Dept of Clinical research, Osaka-Minami Medical Ctr, Osaka, Japan, 3Rheumatology/Orthopaedics, Osaka-Minami Medical Ctr, Kawachinagano, Japan, 4Division of Rheumatology, Osaka-Minami Medical Ctr, Osaka, Japan, 5Rheumatology, Osaka-Minami Medical Ctr, Osaka, Japan, 6Osaka-Minami Medical Ctr, Kawachinagano, Japan

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: ,

Session Information

Date: Monday, November 6, 2017

Title: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy Poster II: Prognostic Factors, Imaging and Miscellaneous Reports

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Biologiccs (Bio) have shown outstanding efficacy and became one of the most effective drugs in the treatment of RA. However, several issues remain, including adverse effect (AE), therapeutic failure (Failure), and expensiveness. On the other hand, cumulative　evidence has suggested that some genetic and environmental factors affects responsivenesss of anti-rheumatic drugs including Bio. Smoking is thought to be one of crucial environmental factors. The purpose of this study is to investigate the influence of smoking on Bio treatment in RA.

Methods: The association between smoking habit and discontinuation of Bio treatment was analyzed on Japanese RA patient cohort (11940 patients). Smoking habit was assessed by questionnaire and the patients were divided into three groups as current smoker, never smoker, ever smoker. The total percentages of discontinuation were analyzed according to four categories: Failure, adverse effect (AE), Remission, and others. The association between the causes of discontinuation of Bio and smoking habit was analyzed statistically.

Results: 3,187 (26.7%) of the total registered patients were treated with one or more Bio during 6 years. Among them, 584, 1,321, 397, 589, 223, and 73 patients were treated with IFX, ETN, ADA, TCZ, ABT and GLM respectively. Failure in the current smoker group was significantly more frequent than never smoker and ever smoker groups (OR=0.678, 95%CI:0.482~0.967, OR=0.577, 95%CI:0.357~0.869, respectively). Among therapeutic targets, patients treated with TNF inhibitors (IFX, ETN, ADA, GLM) showed more significant association between smoking habit and Failure than those treated with either IL-6 inhibitor (TCZ) or T cell inhibitor (ABT).

Conclusion: Smoking reduced responsiveness of treatment by Bio in RA, especially when treated with TNF inhibitors. Smoking cessation may reduce failure of treatment by Bio in RA.

Disclosure: K. Kuzuya, None; Y. Saeki, None; J. Hashimoto, None; S. Oshima, None; M. Matsushita, None; S. Tuji, None; Y. Harada, None; M. Yoshimura, None; S. Teshigawara, None; H. Matsuoka, None.

To cite this abstract in AMA style:

Kuzuya K, Saeki Y, Hashimoto J, Oshima S, Matsushita M, Tuji S, Harada Y, Yoshimura M, Teshigawara S, Matsuoka H. Smoking Reduces Efficacy of Biologics Differently By Target Cytokines in Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/smoking-reduces-efficacy-of-biologics-differently-by-target-cytokines-in-rheumatoid-arthritis/. Accessed .

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