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Abstracts tagged "environmental factors and rheumatoid arthritis (RA)"

  • Abstract Number: 214 • ACR/ARHP Annual Meeting 2018

    Exploring the Relation between Air Pollution and Disease Activity in Patients with Rheumatoid Arthritis

    Tommaso Schioppo1, Valentina Bollati2,3, Chiara Favero2,3, Nicola Ughi1, Isabella Scotti1, Valeria Merlino1, Orazio De Lucia1, Antonella Murgo1 and Francesca Ingegnoli1,3, 1Division of Clinical Rheumatology, G. Pini Hospital, Milan, Italy, 2EPIGET Lab, Milan, Italy, 3Dept. of Clinical Sciences & Community Health, Università degli Studi di Milano, Milan, Italy

    Background/Purpose: Disease remission is considered an achievable target in a significant proportion of patients with rheumatoid arthritis (RA). Nevertheless, diseases flares, that significantly contributes to…
  • Abstract Number: 120 • ACR/ARHP Annual Meeting 2017

    Patients with Rheumatoid Arthritis Have Higher Lifetime Professional and Non-Professional Exposure to Silica Dust Particles Compared to General Population

    Luca Semerano1,2,3, Catherine Cavalin4,5,6, Odile Macchi4,7, Sara El Rharras3, Mylene Petit3, Patrice Decker8,9, Emma Andre10, Paul André Rosental4,11 and Marie-Christophe Boissier12, 1UMR 1125, Inserm, Bobigny, France, 2EA4222, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 3Service de Rhumatologie, Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe hospitalier Avicenne - Jean Verdier – René Muret, Bobigny, France, 4SILICOSIS project, ERC Advanced Grant, Centre for European Studies, Sciences Po, Paris, France, 5Centre for Employment and Labour Studies (CNAM), Noisy-le-Grand, France, 6Laboratory for Interdisciplinary Evaluation of Public Policies (LIEPP, Sciences Po, Paris), Paris, France, 7Centre for Historical Research, CNRS-EHESS, Paris, France, 8Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 9UMR 1125, INSERM, Bobigny, France, 10UMR1125, Inserm, Bobigny, France, 11National Institute for Demographic Studies (INED), Paris, France, 1274 rue Marcel Cachin, INSERM, Bobigny, France

    Background/Purpose: Occupational exposure to silica dust has been associated with increased risk of developing ACPA positive Rheumatoid arthritis (RA)1,2,3. Little is known about non-occupational exposure,…
  • Abstract Number: 1447 • ACR/ARHP Annual Meeting 2017

    Smoking Reduces Efficacy of Biologics Differently By Target Cytokines in Rheumatoid Arthritis

    Kentaro Kuzuya1, Yukihiko Saeki2, Jun Hashimoto3, Shirou Oshima4, Masato Matsushita5, Souichirou Tuji4, Yoshinori Harada6, Maiko Yoshimura6, Satoru Teshigawara6 and Hidetoshi Matsuoka4, 1Rheumatology and Allegology, Osaka-Minami Medical Ctr, Kawachinagano, Japan, 2Dept of Clinical research, Osaka-Minami Medical Ctr, Osaka, Japan, 3Rheumatology/Orthopaedics, Osaka-Minami Medical Ctr, Kawachinagano, Japan, 4Division of Rheumatology, Osaka-Minami Medical Ctr, Osaka, Japan, 5Rheumatology, Osaka-Minami Medical Ctr, Osaka, Japan, 6Osaka-Minami Medical Ctr, Kawachinagano, Japan

    Background/Purpose: Biologiccs (Bio) have shown outstanding efficacy and became one of the most effective drugs in the treatment of RA. However, several issues remain, including…
  • Abstract Number: 987 • ACR/ARHP Annual Meeting 2016

    Pesticide Exposure and Risk of Rheumatoid Arthritis in Licensed Male Pesticide Applicators in the Agricultural Health Study

    Armando Meyer1, Dale Sandler2, Laura Beane-Freeman3, Jonathan Hoffman4 and Christine G. Parks5, 1Occupational and Environmental Health Branch, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 2Epidemiology Branch, NIH/NIEHS, Research Triangle Park, NC, 3Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,, Bethesda, MD, 43Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 5Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC

    Background/Purpose:  We investigated associations between specific pesticides and RA in a cohort of licensed male pesticide applicators/farmers in the Agricultural Health Study (AHS). Of 30,316…
  • Abstract Number: 1214 • ACR/ARHP Annual Meeting 2015

    Rheumatoid Arthritis in Female Spouses in the Agricultural Health Study: Associations with Pesticides and Other Farm Exposures

    Christine G. Parks1, Jane Hoppin2, Karen H. Costenbader3 and Dale Sandler4, 1Epidemiology Branch, National Institute of Environmental Health Science, Research Triangle Park, NC, 2Biological Sciences, North Carolina State University, Raleigh, NC, 3Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4Epidemiology Branch, NIH/NIEHS, Research Triangle Park, NC

    Background/Purpose: Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known. We examined associations between RA, pesticides and other…
  • Abstract Number: 348 • ACR/ARHP Annual Meeting 2014

    Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity: Decreased Inflammation and Disease Improvement with Smoking Cessation?

    Jeremy Sokolove1, Harlan Sayles2, Catriona Wagner3, Lauren J. Lahey1, Geoffrey M. Thiele4, William H. Robinson1, Andreas Reimold5, Gail S. Kerr6, Grant W. Cannon7 and Ted R. Mikuls2, 1VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 2Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 3VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 4Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, 6Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 7Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT

    Background/Purpose: Cigarette smoking is a risk factor for RA and has been associated with increased disease severity and lower rates of disease remission.  We examined…
  • Abstract Number: 1072 • ACR/ARHP Annual Meeting 2013

    Gene-Environment Interaction Between HLA-DRB1 Shared Epitope and Occupational Textile Dust Exposure In The Risk Of ACPA-Positive Rheumatoid Arthritis In Female Patients: Evidence From The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis Case-Control Study

    Chun Lai Too1,2, Nor Asiah Muhamad1, Leonid Padyukov3, Lars Alfredsson4, Camilla Bengtsson5, Lars Klareskog6 and Shahnaz Murad7, 1Institute for Medical Research, Jalan Pahang.Kuala Lumpur, Malaysia, Kuala Lumpur, Malaysia, 2Karolinska Institutet. Department of Medicine. Stockholm, Sweden, Stockholm, Sweden, 3Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 4Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, 5Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 6Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 7Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease with interacting genetic and environmental factors contributing to its etiology. In this study, we investigated…
  • Abstract Number: 72 • ACR/ARHP Annual Meeting 2012

    Relationships Between Air Pollution and Presence of Rheumatoid Arthritis-Related Autoantibodies in Individuals without Rheumatoid Arthritis:  Studies of the Etiology of Rheumatoid Arthritis

    Ryan W. Gan1, Kevin D. Deane2, Gary O. Zerbe3, Michael H. Weisman4, Jane H. Buckner5, P. K. Gregersen6, Ted R. Mikuls7, James R. O'Dell8, Richard M. Keating9, V. Michael Holers10 and Jill M. Norris1, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, 7Internal Medicine, Omaha VA and University of Nebraska Medical Center, Omaha, NE, 8Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 9Rheumatology Section, The University of Chicago, Chicago, IL, 10Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose:   Rheumatoid arthritis (RA) is characterized by the presence of circulating autoantibodies, which can be predictive of future RA development in currently unaffected individuals. …

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