Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease

Latika Gupta¹, Shruti Bhattacharya¹, Vikas Agarwal² and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²clinical Immunology, sanjay Gandhi Postgraduate Institute of Medical Sciences, lucknow, India

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: AS, Inflammation, innate immunity and toll-like receptors

Session Information

Date: Tuesday, November 15, 2016

Title: Spondylarthropathies Psoriatic Arthritis – Pathogenesis, Etiology - Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) show Toll-like receptor 4 (TLR4) over-expression. Myeloid-related proteins (MRP) 8/14 protein complexes are calcium-binding proteins, which act as endogenous ligands to TLR4. Thus we studied the levels of MRP8/14 in adult AS patients.

Methods: MRP8/14 levels were assessed in 99 adult AS patients satisfying ASAS 2010 criteria and 23 healthy controls by ELISA. Patient disease parameters like patient and physician global assessment, BASDAI, swollen and tender joint count, entheseal count by Maastricht Enthesitis index, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein (CRP) were also recorded. Levels were reassessed in 23 patients after 2-5 months of treatment with NSAIDs. All values are in median and IQR.

Results: The median serum MRP8/14 levels in patients [34.1 (17.94-264.58) mg/ml] were significantly higher than in healthy controls [5.97 (IQR 4.64-11.43) mg /ml (p<0.0001)]. Patients with peripheral arthritis (n=50) had higher levels than those with pure axial disease (n=49) [40.63 (IQR 28.41-73.15) mg /ml vs. 23.72 (11.04-61.55) mg /ml; p=0.012]. Levels of MRP8/14 correlated with ASDAS CRP (r=0.23, 95%CI=0.038-0.422, p=0.02) and CRP (r=0.28, 95%CI=0.081-0.45, p=0.01), and the correlation was better in early disease [≤5 years disease duration, (r=0.40, p=0.007) and (r=0.57, p=<0.0001) respectively]. MRP8/14 levels did not correlate with clinical disease activity measures such as BASDAI, Maastricht entheseal count, and patient and physician global assessment. Baseline levels were higher in treatment responders than in non-responders [51.17 vs. 32.22 mg /ml; p=0.02]. Change in MRP8/14 levels correlated with change in BASDAI and ASDAS CRP (r= 0.489, p=0.018 and r=0·498, p=0.016 respectively).

Conclusion: MRP8/14 levels may be used as a biomarker for activity, peripheral arthritis and response to therapy.

Disclosure: L. Gupta, None; S. Bhattacharya, None; V. Agarwal, None; A. Aggarwal, None.

To cite this abstract in AMA style:

Gupta L, Bhattacharya S, Agarwal V, Aggarwal A. Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/elevated-levels-of-serum-myeloid-related-protein-814-in-ankylosing-spondylitis-associated-with-peripheral-arthritis-and-active-disease/. Accessed .

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