ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1813

Prevalence and Incidence of Systemic Lupus Erythematosus in Tucuman -Argentina

Luciana Gonzalez Lucero1, Raul Sueldo2, Alberto Ives Torres3, Alexia Cristofari3, Ana Lucía Barbaglia3, Ana Olea3, Ana Quinteros4, Gladys Seleme3, Francisco Colombres3, Dora Lia Vásquez3, Gustavo Arquez3, Gustavo Alberto Carrizo3, Hector Lazaro3, Maria Josefina Molina3, Laura Juarez3, Maria Constanza Bertolaccini5, Maria Olga Leal6, María Silvia Yacuzzi2, Mariana Espindola Echazu3, Norma Robles De Garrone3, Rodolfo Orlando Dip3, Olga Romano3, Oscar Pera3, Silvia Paz3, Veronica Bellomio7, Maximiliano Machado Escobar2, Silvia Rengel8, Liliana Galindo7, Mirta Santana2 and Eleonora Lucero2, 1Rheumatology Unit, Hospital Padilla, Tucumán, Tucumán, Argentina, 2Hospital Angel Cruz Padilla, Tucumán, Argentina, 3Sociedad de Reumatología de Tucumán, tucuman, Argentina, 4Centro Integral Reumatológico, Tucuman, Argentina, 5Rheumatology, Hospital Angel Cruz Padilla, Tucumán, Argentina, 6Centro Integral De Reumatologia, Tucumán, Argentina, 7Hospital Ángel Cruz Padilla, Tucuman, Argentina, 8Hospital Centro de Salud, Tucuman, Argentina

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords:

Session Information

Date: Monday, November 14, 2016

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment - Poster II: Damage Accrual and Quality of Life

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:  Systemic Lupus Erythematosus (SLE) is the paradigm of the autoimmune diseases that primarily affects women in a ratio of 9: 1. In England and America the prevalence varies from 12 to 42 cases / 100,000 inhabitants and the incidence of 1-3 cases / 100,000 inhabitants. No data on incidence and prevalence of SLE in Argentina is available. The aim of this study is to determine the prevalence and incidence of SLE in the province of Tucuman, Argentina.

Methods:  A cross-sectional study was conducted. Medical records of outpatient and inpatient of 4 hospitals in the province and attended by all doctors of Rheumatology Society of Tucuman (n = 28) except for a center, were reviewed retrospectively. We included patients over 16 years with diagnosis of SLE (4 ACR criteria 1982/1997) residents in the province of Tucuman and with at least two clinic visits between January 2005 and December 2012. We excluded patients with other concomitant diagnosis of autoimmune disease. Demographic variables related to the disease (diagnosis date, age, mortality, cause of death and clinical) were analyzed. The population data were taken from the National Census of 2010. The province of Tucuman has 17 departments with a population of 1,448,716 inhabitants, 45% are in the center area and the remaining 65% distributed in the areas west and south. The population over 16 years is 1,011,188 inhabitants. The prevalence was calculated as the number of cases per 100,000 inhabitants in the period 2005 – 2012 and the annual incidence in the same period.

Results:  353 patients were identified. The mean age at diagnosis was 30.5 ± 11.7 years, 93.5% were women. The prevalence was 25.6 cases / 100,000 inhabitants (95% CI 22.6-28.8) and adjusted for age (≥ 16 years) of 36.7 cases / 100,000 inhabitants (95% CI 32.8-41.1). The annual incidence in 2005: was 1.8 cases / 100,000 inhabitants (95% CI 1-2.9) 2006: of 2 cases / 100,000 inhabitants (95% CI 1.2-3.2), 2007: 1.4 cases / 100,000 inhabitants (95% ; 0.7-2.4), 2008: 2.1 cases / 100,000 inhabitants (95% CI 1.2-2.9), 2009: 2.2 cases / 100,000 inhabitants (95% CI 1.3-3.3), 2010: 2.2 cases / 100,000 population (95 % 1.2-3.3), 2011: of 2.8 cases / 100,000 inhabitants (95% CI, 1.9-4) and 2012: of 4.2 cases / 100,000 inhabitants (95% CI 2.9-5.8). A significant increase of incidence was found comparing the periods 2005 and 2012 (p = 0.0019). Mortality was 9.1%, the most common cause were infections (14/32) .The change rate of deaths corrected by year follow-up is similar to the change in the incidence rate corrected by year of follow up through periods.

Conclusion: The prevalence of SLE in the province of Tucuman was of 36.7 cases / 100,000 inhabitants. The annual incidence in 2005 was 1.8 and in 2012 4.2casos / 100,000 inhabitants. This is the first study of prevalence and incidence of SLE in a population of Argentina.

Disclosure: L. Gonzalez Lucero, None; R. Sueldo, None; A. I. Torres, None; A. Cristofari, None; A. L. Barbaglia, None; A. Olea, None; A. Quinteros, None; G. Seleme, None; F. Colombres, None; D. L. Vásquez, None; G. Arquez, None; G. A. Carrizo, None; H. Lazaro, None; M. J. Molina, None; L. Juarez, None; M. C. Bertolaccini, None; M. O. Leal, None; M. S. Yacuzzi, None; M. Espindola Echazu, None; N. Robles De Garrone, None; R. O. Dip, None; O. Romano, None; O. Pera, None; S. Paz, None; V. Bellomio, None; M. Machado Escobar, None; S. Rengel, None; L. Galindo, None; M. Santana, None; E. Lucero, None.

To cite this abstract in AMA style:

Gonzalez Lucero L, Sueldo R, Torres AI, Cristofari A, Barbaglia AL, Olea A, Quinteros A, Seleme G, Colombres F, Vásquez DL, Arquez G, Carrizo GA, Lazaro H, Molina MJ, Juarez L, Bertolaccini MC, Leal MO, Yacuzzi MS, Espindola Echazu M, Robles De Garrone N, Dip RO, Romano O, Pera O, Paz S, Bellomio V, Machado Escobar M, Rengel S, Galindo L, Santana M, Lucero E. Prevalence and Incidence of Systemic Lupus Erythematosus in Tucuman -Argentina [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-and-incidence-of-systemic-lupus-erythematosus-in-tucuman-argentina/. Accessed .

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