Predictive Factors of Long-Term Clinical Outcome in Patients with Ocular Involvement Secondary to Behcet's Syndrome

Rosaria Talarico¹, Michele Figus², Anna d'Ascanio¹, Rossella Neri¹, Chiara Baldini¹, Chiara Tani³ and Marta Mosca¹, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, Pisa, Italy, ³University of Pisa, Pisa, Italy

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Behcet's syndrome

Session Information

Date: Tuesday, November 10, 2015

Title: Vasculitis Poster III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Behçet’s syndrome (BS) is a multisystemic, chronic relapsing inflammatory disease classified among the vasculitis. Eye involvement represent one of the most serious manifestation of BS and occurs in half of all patients. It seems more frequent and severe among young males and, unluckily, it still represents a significant cause of morbidity. The aim of the study was to identify factors able to predict long-term outcome in patients with BS

Methods: forty-nine patients (29 males and 20 females; mean age at the onset 29±4 years) with a diagnosis of BS according the ISG criteria were studied. The probability of clinical relapse after remission of the first ocular attack was calculated using the Kaplan-Meier method. Predictors of long-term outcome were identified by univariate analysis using the log-rank test and by multivariate analysis using Cox proportional hazards regression models.

Results: The mean time between the first initial symptoms of BS and the onset of eye lesions was 3±2 years. The number of ocular attacks were the following: 32 posterior uveitis, 27 anterior uveitis, 21 retinal vasculitis, while panuveitis developed in 17 subjects. Medical treatments received at time of the study were: cyclosporine A (n=21), infliximab (n=13, azathioprine (11), adalimumab (2). The cumulative relapse rates at 1 year, 3 years, and 5 years after remission of the first ocular attack were 20%, 38.7%, and 42%, respectively. On multivariate analysis, a younger age (<30 years) at the onset of ocular involvement, male sex and medical treatments other than biological agents represent independent predictive factors for relapse in BS patients with ocular involvement.

Conclusion: As awaited, the use of anti TNF alpha agents seems to be associated with a positive effect on maintaining remission in ocular involvement due to BS. However, as literature data suggest, younger age and male sex represent predictive factors of poor long-term clinical outcome.

Disclosure: R. Talarico, None; M. Figus, None; A. d'Ascanio, None; R. Neri, None; C. Baldini, None; C. Tani, None; M. Mosca, None.

To cite this abstract in AMA style:

Talarico R, Figus M, d'Ascanio A, Neri R, Baldini C, Tani C, Mosca M. Predictive Factors of Long-Term Clinical Outcome in Patients with Ocular Involvement Secondary to Behcet’s Syndrome [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/predictive-factors-of-long-term-clinical-outcome-in-patients-with-ocular-involvement-secondary-to-behcets-syndrome/. Accessed .

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