Polymorphisms of Transient Receptor Potential Vanilloid (TRPV) 2 and TRPV3 Gene Polymorphisms Were Associated with Fibromyalgia in a Korean Population

Yi-Rang Yim¹, Dong-Jin Park², Seong-Ho Kim³, Seong-Su Nah⁴, Ji Hyun Lee⁵, Seong-Kyu Kim⁶, Yeon-Ah Lee⁷, Seung-Jae Hong⁸, Hyun-Sook Kim^9,10, Hye-Soon Lee¹¹, Hyoun-Ah Kim¹², Chung-Il Joung¹³, Sang-Hyon Kim¹⁴ and Shin-Seok Lee¹, ¹Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ³Inje University Haeundae Paik Hospital, Busan, South Korea, ⁴Soonchunhyang University, College of Medicine, Cheonan, South Korea, ⁵Internal Medicine, Maryknoll Medical Center, Busan, South Korea, ⁶Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, ⁸Dept. of Rheumatology, #1 Hoeg, KyungHee University Medical Center, SEOUL, South Korea, ⁹Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea, ¹⁰Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University of Korea, Seoul, South Korea, ¹¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹²Ajou University Hospital, Suwon, South Korea, ¹³Internal Medicine, Konyang University Medical School, Daejeon, South Korea, ¹⁴Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: fibromyalgia

Session Information

Date: Tuesday, November 10, 2015

Title: Fibromyalgia, Soft Tissue Disorders, Regional and Specific Clinical Pain Syndromes Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Fibromyalgia (FM) is a chronic pain syndrome characterized by lowered pain thresholds and other FM-related symptoms such as fatigue, anxiety and depression. Recent studies have focused on genetic factors that influence pain sensitivity and development of FM. There are emerging evidences that transient receptor potential vanilloid (TRPV) channels have been contributed to pain hypersensitivity. However, whether polymorphisms of TRPV are associated with FM is unknown. The aim of present study was to evaluate association between polymorphisms of TRPV2 and TRPV3 gene and FM susceptibility, and FM symptoms in a Korean population.

Methods: A total of 409 patients with FM and 423 controls were enrolled from 10 medical centers which participated in the Korean nationwide fibromyalgia survey. The alleles and genotypes at 3 positions [rs3813768(C>G), rs8121(C>T) and rs1129235(C>A)] in the TRPV 2 gene and 2 positions [rs7216486 (G>A) and rs395357(C>T)] in the TRPV 3 gene were genotyped from peripheral blood DNA. The associations of TPPV 2 and TRPV3 genes polymorphisms with FM susceptibility and clinical symptoms of FM were assessed.

Results: The frequencies of alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with susceptibility of FM. However, the GTA haplotype of TRPV2 gene showed protective against fibromyalgia susceptibility after age- and sex adjusted analysis (OR 0.637; 95% CI; 0.418-0.969; P=0.035). Furthermore, SNP rs395357 of TRPV3 was associated with scores of Brief Fatigue Inventory (BFI) (P=0.017) in FM patients. Although haplotypes of TRPV3 did not show different distribution between FM patients and healthy controls, haplotypes of TRPV3 was associated with BFI and the Short Form-36 Health Status Questionnaire (SF-36) physical health summary scores (P=0.036, respectively)

Conclusion: This large-scale study is the first to evaluate association of TRPV gene polymorphisms with fibromyalgia susceptibility and symptom severity of FM. Our results suggested that certain TRPV2 haplotype have a protective role against FM, and also some genotype and haplotype of TRPV3 contribute to fibromyalgia symptoms. Further researches needed to be confirmed.

Disclosure: Y. R. Yim, None; D. J. Park, None; S. H. Kim, None; S. S. Nah, None; J. H. Lee, None; S. K. Kim, None; Y. A. Lee, None; S. J. Hong, None; H. S. Kim, None; H. S. Lee, None; H. A. Kim, None; C. I. Joung, None; S. H. Kim, None; S. S. Lee, None.

To cite this abstract in AMA style:

Yim YR, Park DJ, Kim SH, Nah SS, Lee JH, Kim SK, Lee YA, Hong SJ, Kim HS, Lee HS, Kim HA, Joung CI, Kim SH, Lee SS. Polymorphisms of Transient Receptor Potential Vanilloid (TRPV) 2 and TRPV3 Gene Polymorphisms Were Associated with Fibromyalgia in a Korean Population [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/polymorphisms-of-transient-receptor-potential-vanilloid-trpv-2-and-trpv3-gene-polymorphisms-were-associated-with-fibromyalgia-in-a-korean-population/. Accessed .

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