Session Information
Date: Monday, November 9, 2015
Title: Imaging of Rheumatic Diseases Poster II: X-ray, MRI, PET and CT
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Several scores have been developed to assess radiographic damage in AS. However, we do not know how they perform in early phases of the disease. Our aim was to compare the performance of different radiographic scores of the spine in patients with early axial spondyloarthritis (axSpA).
Methods: Yearly radiographs from a 2-year follow-up of the DESIR cohort from patients fulfilling the ASAS axSpA criteria have been used. Spinal (cervical, thoracic and lumbar) and sacro-iliac (SI) radiographs were scored independently by two readers for the presence of the different damage aspects enabling the calculation of different scores: mSASSS (0-72), SASSS (0-72), RASSS (0-84) and BASRI-spine (0-12), using the averaged scores between readers per vertebral corner (VC)/SI joints. Additionally, a variation of the BASRI-spine was computed adding an overall score for the thoracic spine (0-16). Following the OMERACT proposal, scores were compared with regard to truth, discrimination (sensitivity to change and reliability) and feasibility. Status (at baseline of first x-ray available) and 2-year progression scores were calculated for each of the methods as well as the proportion of patients with any change (change>0).
Results: In total, 486 patients (mean age 33.0 (SD 8.6) years, 50% males) had at least one radiograph available. At baseline, scores ranged from 0 and 21.6 for the mSASSS (30% of the maximum of the scale), 20.6 for RASSS (25% of maximum), 6 for SASSS (8% of maximum), 8.5 for BASRI-spine (71% of maximum) and 10.25 for BASRI-spine with thoracic spine (64% of maximum). Status scores and 2-year progression scores available are shown in the table. The proportion of patients with any 2-year change was the following: 9.9% for mSASSS, 10.7% for RASSS, 6.9% for SASSS, 19.2% for BASRI-spine and 22.0% for BASRI-spine with thoracic spine. Absolute change scores (table) showed that the mSASSS and RASSS captured most change. 2-year RASSS progression occurred in a balanced way across segments (cervical, thoracic and lumbar), when taking the number of VCs included per segment. All scores had acceptable reliability. In what concerns feasibility, all scores seemed to be feasible, but the BASRI-spine (+/- thoracic spine) was more frequently missing (up to 15% of the cases), as it requires also the availability of SI joints.
Table – Status and 2-year progression for the different radiographic scoring methods
|
|
mSASSS mean (SD) n = 481 |
RASSS mean (SD) n = 481 |
SASSS mean (SD) n = 483 |
BASRI spine mean (SD) n = 447 |
BASRI spine with thoracic mean (SD) n = 442 |
|
STATUS SCORES |
|||||
|
Total score |
0.57 (2.37) |
0.54 (2.34) |
0.17 (1.03) |
1.35 (1.62) |
1.46 (1.80) |
|
Cervical segment |
0.36 (1.69) |
0.34 (1.66) |
— |
0.16 (0.55) |
0.17 (0.55) |
|
Lumbar segment |
0.21 (1.09) |
0.16 (1.04) |
0.17 (1.03) |
0.18 (0.54) |
0.19 (0.55) |
|
Lumbar segment with thoracic segment included |
— |
0.19 (1.13) |
— |
— |
— |
|
Thoracic segment |
— |
0.03 (0.28) |
— |
— |
0.09 (0.38) |
|
Lumbar anterior |
— |
— |
0.16 (1.03) |
— |
— |
|
Lumbar posterior |
— |
— |
0.00 (0.02) |
— |
— |
|
SI joints |
— |
— |
— |
1.00 (1.13) |
1.00 (1.13) |
|
2-YEAR PROGRESSION SCORES |
|||||
|
|
mSASSS n = 322 |
RASSS n = 319 |
SASSS n = 335 |
BASRI spine n = 287 |
BASRI spine with thoracic n = 268 |
|
Total score |
0.27 (1.57) |
0.36 (1.74) |
0.15 (0.78) |
0.05 (0.72) |
0.07 (0.83) |
|
Cervical segment |
0.19 (1.16) |
0.17 (1.18) |
— |
0.04 (0.36) |
0.03 (0.35) |
|
Lumbar segment |
0.08 (0.63) |
0.13 (0.66) |
0.15 (0.78) |
0.01 (0.40) |
0.02 (0.35) |
|
Lumbar segment with thoracic segment included |
— |
0.18 (0.84) |
— |
— |
— |
|
Thoracic segment |
— |
0.06 (0.38) |
— |
— |
0.00 (0.32) |
|
Lumbar anterior |
— |
— |
0.13 (0.65) |
— |
— |
|
Lumbar posterior |
— |
— |
0.02 (0.33) |
— |
— |
|
SI joints |
— |
— |
— |
0.01 (0.36) |
0.01 (0.37) |
Conclusion: The existing scoring methods to assess radiographic damage performed well in early phases of axSpA. The mSASSS and RASSS captured most change, but there was no gain in additionally scoring the thoracic spine for the RASSS. The mSASSS remains the most sensitive and most adequate scoring method in axSpA, including early phases of the disease.
To cite this abstract in AMA style:
Ramiro S, Claudepierre P, van den Berg R, Navarro-Compán V, Feydy A, d'Agostino MA, Loeuille D, Dougados M, Reijnierse M, van der Heijde D. Which Score to Use for Radiographic Damage Assessment of the Spine in (early) Axial Spondyloarthritis? Two-Year Data from the DESIR Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/which-score-to-use-for-radiographic-damage-assessment-of-the-spine-in-early-axial-spondyloarthritis-two-year-data-from-the-desir-cohort/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/which-score-to-use-for-radiographic-damage-assessment-of-the-spine-in-early-axial-spondyloarthritis-two-year-data-from-the-desir-cohort/