ACR Meeting Abstracts

ACR Meeting Abstracts

Abstracts tagged "X chromosome"

  • Abstract Number: 66 • ACR/ARHP Annual Meeting 2016

    Very Rare X Chromosome Abnormalities in SLE and SjöGren’s May Localize X Gene Dose Effect

    Rohan Sharma1, Valerie M Harris2, Joshua Cavett3, Biji T Kurien3, Ke Liu4, Kristi A. Koelsch5, Lida Radfar6, David M. Lewis7, Donald U. Stone8, C. Erick Kaufman9, Shibo Li10, Barbara M. Segal11, Daniel J Wallace12, Michael Weisman13, Jennifer A. Kelly14, Bernado Pons-Estel15, Roland Jonsson16, Jacques-Eric Gottenberg17, Juan-Manuel Anaya18, Deborah S. Cunninghame-Graham19, Vivian P. Bykerk20, Gideon Hirschfield21, Gang Xie22, Wan-Fai Ng23, Gunnel Nordmark24, Per Eriksson25, Roald Omdal26, Nelson L. Rhodus27, Maureen Rischmueller28, Michael D. Rohrer29, Marie Wahren-Herlenius30, Torsten Witte31, Xavier Mariette32, Christopher J. Lessard33, John B. Harley34, Kathy L. Sivils33, Astrid Rasmussen35, R. Hal Scofield33, Swamy Venturopalli36, Xianglan Lu10, Pamela Hughes37, Andrew J.W. Huang38 and Corinnine Miceli-Richard39, 1Medical Service, US Department of Veterans Affaris Medical Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 43333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, 5U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 6Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 8King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 9Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 10Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, 12Cedars-Sinai Medical Center, West Hollywood, CA, 13Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 14Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Sanatorio Parque, Rosario, Argentina, 16Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 17Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 18Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, 19Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, 20Divison of Rheumatology, Hospital for Special Surgery, New York, NY, 21Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 22Mount Sinai Hospital, Toronto, ON, Canada, 23Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 24Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 25University Hospital, Rheumatology clinic, Linköping, Sweden, 26Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, 27Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 28Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, 29Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, 30Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, 31Hannover Medical School, Hanover, Germany, 32Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France, 33Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 34Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, 35Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 36Rheumatology, Cedars Syani Medical Center, Los Angeles, CA, 37Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, 38Washington University,, St Louis, MO, 39Rheumatology, Université Paris-Sud, Paris, France

    Background/Purpose:  Sjögren’s syndrome and systemic lupus erythematosus (SLE) are chronic, autoimmune diseases that are related by clinical and serological manifestations as well as genetic risks.…

  • Abstract Number: 648 • ACR/ARHP Annual Meeting 2015

    Klinefelter’s Syndrome (47,XXY) Among Men with Sjögren’s Syndrome

    Valerie M Harris1, Joshua Cavett2, Biji Kurien3, Ke Liu4, Kristi A. Koelsch5, Lida Radfar6, David M. Lewis7, Donald U. Stone8, Shibo Li9, Barbara Segal10, Daniel J Wallace11, Michael H. Weisman12, Jennifer A. Kelly13, Marta Alarcon-Riquelme14, Bernado Pons-Estel15, Roland Jonsson16, Xianglan Lu9, Jacques Gottenberg17, Juan-Manuel Anaya18, Deborah S. Cunninghame-Graham19, Edward C. Keystone20, Andrew J.W. Huang21, Michael T. Brennan22, Pamela Hughes23, G Illei24, Corinne Miceli25, VP Bykerk26, Gideon Hirschfield27, Gang Xie28, Wan-Fai Ng29, Gunnel Nordmark30, Per Eriksson31, Roald Omdal32, Nelson L. Rhodus33, Maureen Rischmueller34, Michael D. Rohrer35, Marie Wahren-Herlenius36, Torsten Witte37, Xavier Mariette38, Christopher Lessard39, John B. Harley40, Kathy L. Sivils39 and Robert Hal Scofield41, 1Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 43333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, 5Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 6Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, 7College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 9Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10Rheumatology, Univ of Minnesota, Minneapolis, MN, 11Cedars-Sinai Medical Center, West Hollywood, CA, 12Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 13Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 14Arthritis & Clinical Immunology, Oklahoma Medical REsearch Foundtion, Oklahoma City, OK, 15Hospital Provincial de Rosario, Rosario, Argentina, 16Broegelmann research laboratory, Bergen, Norway, 17Hautepierre, Strasbourg, France, 18Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, 19Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, 20Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 21Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, 22Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, 23Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, 24Sjögren's Clinic, NIDCR/NIH, Bethesda, MD, 25Rheumatology, PARIS, France, 26University of Toronto, Toronto, ON, Canada, 27Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 28Mount Sinai Hospital, Toronto, ON, Canada, 29Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 30Medical Sciences, Uppsala University, Uppsala, Sweden, 31University Hospital, Rheumatology clinic, Linköping, Sweden, 32Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, 33Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, 34Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, 35Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, 36Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, 37Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, 38Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, 39Oklahoma Medical Research Foundation, Oklahoma City, OK, 40Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 41Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: Primary Sjögren’s syndrome (pSS) has a strong female bias of greater than 10 to 1. This difference in risk of disease between the sexes…