Abstracts tagged "WNT Signaling"

Abstract Number: 233 • 2014 ACR/ARHP Annual Meeting
Significance of Serum Marker Levels of Wnt/ß-Catenin Signaling Pathway in Patients with Systemic Autoimmune Diseases Under Glucocorticoid Therapy; A Prospective Study
Mai Kawazoe, Kotaro Shikano, Kaichi Kaneko, Shotaro Masuoka, Hiroshi Sato, Emiko Shindo, Natsuki Fujio, Sei Muraoka, Makoto Kaburaki, Nahoko Tanaka, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki, Tomoko Hasunuma and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Glucocorticoids are widely used to treat a variety of diseases, including systemic autoimmune diseases. Although glucocorticoids improve the outcome for patients with these diseases,…
Abstract Number: 2709 • 2013 ACR/ARHP Annual Meeting
Secreted Frizzled-Related Protein 4 Can Be Induced By Transforming Growth Factor-β, Is Regulated By Caveolin-1 and Can Induce Non-Canonical Wnt Signaling In Fibroblasts
Justin Gillespie¹, Giuseppina Abignano¹, Michael McDermott¹, Paul Emery¹ and Francesco Del Galdo², ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is a heterogeneous disease characterized by autoimmune activation, fibroproliferative vasculopathy, and tissue fibrosis of skin and multiple internal organs. Several studies…
Abstract Number: 2213 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Normalizes Both DKK-1 and Sclerostin As Wnt Inhibitors In a Mouse Model Of Collagen-Induced Arthritis
Hiroto Yoshida¹, Mika Yagoto¹, Miho Suzuki¹, Keisuke Tanaka¹, Isao Matsumoto², Takayuki Sumida³ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: The Wnt pathway plays an important role in bone formation and regeneration. This pathway is regulated by several soluble inhibitors such as Dickkopf-1 (DKK-1)…
Abstract Number: 1144 • 2013 ACR/ARHP Annual Meeting
Wnt Signaling Pathway Regulates Multi-Unconventional Differentiation and Function Of Human Dendritic Cells
Jia Wang¹, Yi Liu² and Yi Zhao², ¹General medical center, Sichuan Provincial People's Hospital, Chengdu, China, ²Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China
Background/Purpose: Dendritic cells (DCs) play a central role in regulating immune responses and govern T cell priming and polarization, mediating immunity and tolerance. Recent progress…
Abstract Number: 769 • 2013 ACR/ARHP Annual Meeting
Synovial Wnt and WISP1 Expression Induces Expression Of Cartilage-Degrading Metalloproteinases In The Synovium
Martijn H. van den Bosch¹, Arjen B. Blom¹, Sylvia W. Suen², Anke E. van Erp², Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan³, Peter L. van Lent⁴ and Wim B. van den Berg⁵, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. Previously, we found strong upregulation of Wnts 2b and 16 and…
Abstract Number: 529 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis and Dysfunctional Dkk
Rajbir Gulati¹, Maripat Corr², Michael H. Weisman³ and David Hallegua⁴, ¹Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, ²Medicine, Univ of California-San Diego, La Jolla, CA, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Medicine, Cedars-Sinai/UCLA, Beverly Hills, CA
Background/Purpose: Ankylosing Spondylitis (AS) is characterized by inflammation of the spine and entheses followed by formation of syndesmophytes. Wnt pathway is a regulator of bone…
Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Jessica Bertrand¹, Tabea Kräft², Yvonne Nitschke³, Thelonius Hawellek⁴, Jan Hubert⁴, Lars Godmann⁵ and Thomas Pap⁵, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Inst, University Hospital Münster, Muenster, Germany, ³University Hospital Münster, Muenster, Germany, ⁴University Hospital Hamburg, Hamburg, Germany, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…

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