Abstracts tagged "WNT Signaling"

Abstract Number: 312 • 2015 ACR/ARHP Annual Meeting
Safety, Efficacy and Biomarker Outcomes of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
Yusuf Yazici¹, Timothy E. McAlindon², Roy Fleischmann³, Allan Gibofsky⁴, Nancy E. Lane⁵, Alan J. Kivitz⁶, Nebojsa Skrepnik⁷, Eddie Armas⁸, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeyanesh R. S. Tambiah¹, John Hood¹ and Marc C. Hochberg⁹, ¹Samumed, San Diego, CA, ²Tufts Medical Center, Boston, MA, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴Weill Cornell Medical College and Hospital for Special Surgery, New York, NY, ⁵UC Davis Medical Center, Sacramento, CA, ⁶Altoona Center for Clinical Research, Duncansville, PA, ⁷Tucson Orthopaedic Institute, Tucson, AZ, ⁸Well Pharma Medical Research, Miami, FL, ⁹University of Maryland School of Medicine, Baltimore, MD, USA, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by the destruction of articular cartilage, subchrondral bone alterations and varying degrees of synovitis. Current OA treatments are limited…
Abstract Number: 313 • 2015 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Outcomes Using an Intra-Articular Injection (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study
Yusuf Yazici¹, Sharmila Majumdar², Timothy E. McAlindon³, Roy Fleischmann⁴, Allan Gibofsky⁵, Marc C. Hochberg⁶, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeyanesh R. S. Tambiah¹, John Hood¹ and Nancy E. Lane⁷, ¹Samumed, San Diego, CA, ²Radiology, UCSF School of Medicine, San Francisco, CA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Weill Cornell Medical College and Hospital for Special Surgery, New York, NY, ⁶Department of Medicine, University of Maryland, Baltimore, MD, ⁷Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA
Background/Purpose: Knee osteoarthritis (OA) is characterized by the destruction of articular cartilage, subchrondral bone alterations and varying degrees of synovitis. Current OA treatments are limited…
Abstract Number: 1170 • 2015 ACR/ARHP Annual Meeting
The Alarmins S100A8/A9 Induce Canonical Wnt Signaling in Naïve Joints and Experimental OA
Martijn H. van den Bosch¹, Arjen Blom¹, Rik Schelbergen², Thomas Vogl³, Johannes Roth⁴, Wim van den Berg¹, Peter van der Kraan¹ and Peter van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Institute of Immunology, University of Muenster, Munster, Germany, ⁴Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found increased expression of both the…
Abstract Number: 1265 • 2015 ACR/ARHP Annual Meeting
Genetic and Epigenetic Mapping of Very Early RA Synovial Fibroblasts
Emmanuel Karouzakis¹, Andrew Filer², Stephen Eyre³, Karim Raza⁴, Christoph Kolling⁵, Renate E. Gay¹, Beat A. Michel¹, Jane Worthington³, Christopher Buckley⁶, Steffen Gay¹, Michel Neidhart¹ and Caroline Ospelt¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²University of Birmingham, Birmingham, United Kingdom, ³University of Manchester,Institute of Inflammation and Repair, United Kingdom, Manchester, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁵Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁶University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Genome wide association studies (GWAS) studies from rheumatoid arthritis patients have identified SNPs, which are associated with changes in gene expression levels. Recent studies…
Abstract Number: 1744 • 2015 ACR/ARHP Annual Meeting
Free DKK-1 Serum Levels Are Unchanged in Spondyloarthritis Patients Treated By Etanercept
Corinne Miceli-Richard¹, Bernard Combe², Francis Berenbaum³, Thierry Schaeverbeke⁴, Maria Dilleen⁵, Nandan Koppiker⁶, Isabelle Logeart⁷, Arnaud Dubanchet⁷ and Maxime Dougados⁸, ¹Rhuematology, Cochin Hospital, Paris Descartes University, Paris, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Rheumatology and Paris VI University, Saint-Antoine Hospital, Paris, France, ⁴Rheumatology, CHU Bordeaux, Bordeaux, France, ⁵Pfizer GIPB, Sandwich, United Kingdom, ⁶Pfizer PGRD, Sandwich, United Kingdom, ⁷Pfizer, Paris, France, ⁸Paris-Descartes University, Paris, France
Background/Purpose: DKK-1 and SOST are two inhibitory proteins of the Wnt signaling pathway that lead to decreased bone formation by osteoblasts and osteocytes, respectively. Functional…
Abstract Number: 1926 • 2015 ACR/ARHP Annual Meeting
Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis
Chih-Wei Chen¹, Neng-Yu Lin¹, Yun Zhang¹, Jingang Huang¹, Katrin Palumbo-Zerr¹, Alexandra Schambony², Christian Beyer¹, Georg Schett¹ and Jeorg HW Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Biology, Development Biology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: While canonical Wnt/beta-catenin signaling has been identified as a core pathway of fibrosis in SSc, non-canonical Wnt signaling pathways have not yet been analyzed.…
Abstract Number: 2008 • 2015 ACR/ARHP Annual Meeting
WISP1 Aggravates Osteoarthritis By Modulation of TGF-β Signaling and Positive Regulation of Canonical Wnt Signaling
Martijn H. van den Bosch¹, Arjen Blom¹, Azusa Maeda², Tina Kilts², Wim van den Berg¹, Floris Lafeber³, Peter van Lent¹, Marian Young² and Peter van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²NIDCR/NIH, Bethesda, MD, ³Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is suggested to be involved in joint destruction. Previously, we found synovial overexpression of Wnt ligands in experimental…
Abstract Number: 2064 • 2015 ACR/ARHP Annual Meeting
Increase in IL-31 Serum Level in Recent Onset Spondyloarthritis – Data from the DESIR Cohort
Nicolas Rosine Jr.¹, Adrien Etcheto², Anna Moltó³, Yassine Taoufik⁴, Houria Chavez⁴, Christian Roux⁵, Karine Briot⁵, Maxime Dougados⁶ and Corinne Miceli⁵, ¹Rheumatology Department, Hôpital Kremlin Bicêtre, Paris, France, ²Rheumatology B, Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ³Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP. INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité,, Paris, France, ⁴Biologic Immunology, Hopital Bicetre, Université Paris Sud, AP-HP, Kremlin Bicetre, France, ⁵Rheumatology B Department, Hôpital Cochin, Paris, France, ⁶Rheumatology B Department,, Paris-Descartes University, APHP, Cochin Hospital, Paris, France
Background/Purpose: IL-31 is a newly-described cytokine mainly produced by activated Th2 cells. IL-31 acts through IL31-RA and oncostatin heterodimeric receptors that activate STAT3 and STAT5. So far, IL31 has…
Abstract Number: 412 • 2014 ACR/ARHP Annual Meeting
Determinants of Radiological Progression in Rheumatoid Arthritis: Relationship with Serum Levels of OPG, RANKL and DKK-1
Carmen Gómez-Vaquero¹, Irene Martín-Esteve¹, Jose Ivorra², Jose Antonio Narvaez³, Javier Hernandez Gañan³, Pedro Alia⁴ and Javier Narváez⁵, ¹Rheumatology Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, ²Department of Rheumatology, Hospital Universitario y Politécnico La Fe., Valencia, Spain, ³Radiology Department, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, ⁴Clinical Laboratory Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, ⁵Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain
Background/Purpose: Osteoprotegerin (OPG), RANKL, and DKK-1 act as regulators of bone resorption and formation. The uncoupling of bone remodelling that occurs in rheumatoid arthritis (RA)…
Abstract Number: 233 • 2014 ACR/ARHP Annual Meeting
Significance of Serum Marker Levels of Wnt/ß-Catenin Signaling Pathway in Patients with Systemic Autoimmune Diseases Under Glucocorticoid Therapy; A Prospective Study
Mai Kawazoe, Kotaro Shikano, Kaichi Kaneko, Shotaro Masuoka, Hiroshi Sato, Emiko Shindo, Natsuki Fujio, Sei Muraoka, Makoto Kaburaki, Nahoko Tanaka, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki, Tomoko Hasunuma and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Glucocorticoids are widely used to treat a variety of diseases, including systemic autoimmune diseases. Although glucocorticoids improve the outcome for patients with these diseases,…
Abstract Number: 2948 • 2014 ACR/ARHP Annual Meeting
S100 Proteins Induce Canonical Wnt Signaling, Which Causes Increased Expression of MMPs in the Synovium
Martijn H. van den Bosch¹, Arjen B. Blom², R. Pelle Hoek², Rik F. Schelbergen³, Sylvia W. Suen², Anke E. van Erp², Wim B. van den Berg¹, Peter M. van der Kraan¹ and Peter L. van Lent⁴, ¹Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Radboud university medical center, Nijmegen, Netherlands, ⁴Experimental Rheumatology, Experimental Rheumatology, Radboud University, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found that the alarmins S100A8 and A9,…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 2585 • 2014 ACR/ARHP Annual Meeting
Association of Smoking with Acute Phase Reactants and Molecules Involved in Bone Formation in Patients with Ankylosing Spondylitis
Grigorios Sakellariou¹, Spyros Gerou², Dimitrios Oikonomou³ and Fares Sayegh⁴, ¹Rheumatology, 424 General Military Hospital, Thessaloniki, Greece, ²Laboratories "Analysis", Thessaloniki, Greece, ³Biopathology, 424 General Military Hospital, Thessaloniki, Greece, ⁴3rd Orthopaedic, "Papageorgiou" General Hospital, Thessaloniki, Greece
Background/Purpose: In patients with ankylosing spondylitis (AS), smoking is associated with increased disease activity and more radiographic damage. However, the mechanisms underlying the effects of…
Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting
IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis
Anita T. Shaw¹, Yukiko Maeda¹, Catherine Manning¹ and Ellen M. Gravallese^1,2, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…
Abstract Number: 1018 • 2014 ACR/ARHP Annual Meeting
Monolayer Culture Induced the Expression of Zyxin-Related Protein 1 (ZRP-1), α_vβ₃integrin Complex and Leptin in Human Articular Chondrocytes
Edith Charlier¹, Olivier Malaise¹, Mustapha Zeddou², Sophie Neuville³, Gaël Cobraiville³, Philippe Gillet⁴, William Kurth⁴, Dominique de Seny¹, Biserka Relic¹ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco, ³GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ⁴Orthopedic Surgery Unit-CHU of Liège, Liège, Belgium
Background/Purpose During Osteoarthritis (OA), chondrocytes loose their initial anabolic properties, undergoing morphological and biochemical modifications similar to those encountered during chondrocyte dedifferentiation. However, the molecular…

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