Abstracts tagged "WNT Signaling and rheumatoid arthritis (RA)"

Abstract Number: 2506 • ACR/ARHP Annual Meeting 2016
Seropositivity Predicts Bone Biomarker Change in an Inception Cohort of Rheumatoid Arthritis Patients Treated-to-Target with Combination Conventional DMARD Therapy
Mihir D. Wechalekar^1,2, Susan Lester³, Sunil Nagpal⁴, Jessica Peters⁵, Anuk Das⁶, Pravin Hissaria^7,8, Tania Crotti⁹, Llew Spargo¹⁰, Jennifer G Walker^1,2,10, Malcolm D. Smith¹ and Susanna M Proudman^9,10, ¹Flinders University, Adelaide, Australia, ²Rheumatology Unit, Repatriation General Hospital, Adelaide, Australia, ³Rheumatology, Queen Elizabeth Hospital, Woodville South, Australia, ⁴Immunology, Janssen Research & Development, Spring House, PA, ⁵Janssen Research & Development, Spring House, PA, ⁶Janssen R&D, Berwyn, PA, ⁷Royal Adelaide Hospital, Adelaide, Australia, ⁸Immunology, SA Pathology, Adelaide, Australia, ⁹University of Adelaide, Adelaide, Australia, ¹⁰Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Background/Purpose: There are limited data regarding the role of and response to treatment, of bone biomarkers in early rheumatoid arthritis (RA) treated with conventional DMARDs.…
Abstract Number: 2562 • ACR/ARHP Annual Meeting 2015
The Inhibition of Wnt/Beta-Catenin Signaling Pathway Via Paricalcitol and Pyrvinium Ameliorates Experimental Arthritis
Suleyman Serdar Koca¹, Servet Yolbas², Ahmet Yildirim², Ahmet Tektemur³, Zulfinaz Betul Celik³, Ebru Etem Onalan³, Ibrahim Hanifi Ozercan⁴ and Mustafa Akin⁴, ¹İnternal Medicine Division of Rheumatology, Firat University, Faculty of Medicine, Elazig, Turkey, ²Rheumatology, Department of Rheumatology, Firat University, Elazig, Turkey, ³Department of Medical Biology Faculty of Medicine, Firat University, Elazig, Turkey, ⁴Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) display…