Abstracts tagged "WNT Signaling and osteoarthritis"

Abstract Number: 2368 • 2016 ACR/ARHP Annual Meeting
Analysis of Pain and Function Components in Omeract-Oarsi Strict Responders from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
Vibeke Strand¹, Christopher J. Swearingen², Ismail Simsek², Anita DiFrancesco², Jeymi Tambiah² and Yusuf Yazici², ¹Stanford University School of Medicine, Palo Alto, CA, ²Samumed, LLC, San Diego, CA
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional impairment, disability, and joint space narrowing due to degradation of articular cartilage and bone remodeling. The…
Abstract Number: 2007 • 2015 ACR/ARHP Annual Meeting
Discovery of an Intra-Articular Injection Small Molecule Inhibitor of the Wnt Pathway (SM04690) As a Potential Disease Modifying Treatment for Knee Osteoarthritis
Charlene Barroga, Yong Hu, Vishal Deshmukh and John Hood, Samumed, San Diego, CA
Background/Purpose: Wnt has a key role in the formation of bone, cartilage and synovium. Increased Wnt signaling may contribute to initiation and progression of osteoarthritis…

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