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Abstracts tagged "WNT Signaling and ankylosing spondylitis (AS)"

  • Abstract Number: 1672 • ACR/ARHP Annual Meeting 2016

    Microrna-29a Activation of Canonical Wnt Signaling By Targeting LRP6 in Ankylosing Spondylitis

    Jinxian Huang1, Zhihua Yin2, Zhongchao Fu3, Zhizhong Ye3 and Lijun Zhang4, 1Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, 2Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, 3The Fourth People’s Hospital of Shenzhen, Shenzhen, China, 4The University of Hong Kong-Shenzhen Hospital, Shenzhen, China

    Background/Purpose: Aberrant regulation of the Wnt pathway is a key element in the pathogenesis of Ankylosing spondylitis (AS). We previously found that miR-29a was significantly…
  • Abstract Number: 603 • ACR/ARHP Annual Meeting 2014

    Periostin May Have a Role in Ankylosing Spondylitis and It Is Associated with Wnt Signalling Pathway Regulators

    Servet Akar1, Saadettin Uslu2, Leyla Didem Kozaci3, Gercek Can4, Neslihan Karaca5, Emine Figen Tarhan4, Mustafa Ozmen6 and Dilek Solmaz7, 1Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine,, Izmir, Turkey, 2Department of Internal Medicine, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 3Department of Medical Biochemistry, Adnan Menderes University School of Medicine, Aydin, Turkey, 4Internal Medicine Clinic, Division of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, 5Adnan Menderes University, Science Thecnology Research and Application Center, Aydin, Turkey, 6Internal Medicine Clinic, D,v,s,on of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, 7Department of Internal Medicine, Division of Rheumatology, Namik Kemal University School of Medicine, Tekirdag, Turkey

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic rheumatic disease characterized by sacroiliac and spinal inflammationand new bone formation (syndesmophyte). Molecular mechanisms underlying this process have…

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