ACR Meeting Abstracts

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Abstracts tagged "Wegener’s granulomatosis"

  • Abstract Number: 1765 • 2017 ACR/ARHP Annual Meeting

    Validation of the ACR EULAR Provisional 2017 Classification Criteria of Granulomatosis with Polyangiitis (GPA) Amongst Patients with ANCA Associated Vasculitis

    Aman Sharma1, Adarsh MB2, Shankar Naidu3, Manish Rathi4, Benzeeta Pinto5, Varun Dhir6, Roshan Verma7, Kusum Sharma8, Ritambhra Nada9, Sanjay Jain5 and Ranjana Minz10, 1Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Internal Medicine, PGIMER, Chandigarh, India, 3PGIMER, cHANDIGARH, India, 4Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 5PGIMER, CHANDIGARH, India, 6Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7PGIMER, Chandigarh, India, 8Department of Medical Microbiology,, PGIMER,, Chandigarh, India, 9Histopathology, Professor, Chandigarh, India, 10Department of Immunopathology,, PGIMER,, Chandigarh, India

    Background/Purpose: The purpose of this study was to validate the recently proposed ACR EULAR 2017 classification criteria of GPA in a real life cohort of…
  • Abstract Number: 1770 • 2017 ACR/ARHP Annual Meeting

    ANCA-Associated Vasculitis (AAV) in Younger Vs Older Patients:  Comparison of Clinical, Serologic and Outcome Differences and Their Implications for Management

    Priya Chokshi1, Olufemi Aina2, Naveed Masani2, Melissa Fazzari3, Elise Belilos1, Kristina Belostocki1, Gary Rosenblum1, Tobin Abraham4, Daniil Shimonov4, Zinal Patel4 and Steven E. Carsons1, 1Rheumatology, NYU Winthrop Hospital, Mineola, NY, 2Nephrology, NYU Winthrop Hospital, Mineola, NY, 3Biostatistics, NYU Winthrop Hospital, Mineola, NY, 4Medicine, NYU Winthrop Hospital, Mineola, NY

    Background/Purpose: ANCA-associated vasculitis (AAV) is a cause of multi-organ disease in all ages, but peaks at ages 65-74. Limited data is available on the characteristics…
  • Abstract Number: 1777 • 2017 ACR/ARHP Annual Meeting

    Incidence and Prevalence of Granulomatosis with Polyangiitis and Microscopic Polyangiitis in a Health Management Organization: A 15-Year Study

    Florencia Pierini1, Marina Scolnik1, Valeria Scaglioni2, Florencia Beatriz Mollerach3 and Enrique R. Soriano1, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 2Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, CABA, Argentina, 3Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: ANCA-associated vasculitides are rare diseases and epidemiological data on them is scarce. Our objective was to estimate incidence and prevalence rates of Granulomatosis with…
  • Abstract Number: 1847 • 2017 ACR/ARHP Annual Meeting

    The IgG4:IgG RNA Ratio in Peripheral Blood Perfectly Differentiates Active Disease from Remission in Granulomatosis with Polyangiitis. a New Disease Activity Marker?

    Aram Al-Soudi1,2,3, Marieke E. Doorenspleet4, Rebecca Esveldt5, Lot Burgemeister5, Liesbeth Hak5, Sander W. Tas6, Ronald F van Vollenhoven7, Paul L. Klarenbeek5,8 and Niek de Vries5,9, 1Dept of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands, 2Dept of Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Dept of Genome Analysis, Academic Medical Center, Amsterdam, Netherlands, 4ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 7Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 8Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 9Laboratory of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Granulomatosis with Polyangiitis (GPA) is characterized by vasculitis in lungs, kidneys and the ear, nose and throat region. Regular monitoring and treatment adjustments are…
  • Abstract Number: 893 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Belimumab in Combination with Azathioprine for Remission Maintenance in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: A Multicenter Randomized, Placebo-Controlled Study

    David Jayne1, Daniel Blockmans2, Raashid Luqmani3, Beulah Ji4, Yulia Green5, Leanne Hall6, David Roth7 and Peter A. Merkel8, 1Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 2General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium, 3Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 4GSK Stockley Park, Uxbridge, United Kingdom, 5GSK Stockley Park, Stockley Park, United Kingdom, 6GSK Stevenage, Stevenage, United Kingdom, 7GSK Collegeville, Collegeville, PA, 8Division of Rheumatology, University of Pennsylvania, Philadelphia, MN

    Background/Purpose: GPA (Wegener’s) and MPA are organ- and life-threatening systemic vasculitides characterized by the presence of ANCA-associated vasculitis (AAV), implicating B cells in disease pathogenesis.…
  • Abstract Number: 1930 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Glucocorticoid Exposure in ANCA-Associated Vasculitis

    Matthew D. Cascino1, Ulrich Specks2, Peter A. Merkel3, Philip Seo4, Robert F. Spiera5, Carol A. Langford6, Gary S. Hoffman6, Cees G.M. Kallenberg7, E. William St Clair8, Paul A. Monach9, John H. Stone10 and Paul Brunetta11, 1Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Mayo Clinic, Rochester, MN, 3Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 4Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 7Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 8Rheumatology, Duke University Medical Center, Durham, NC, 9Rheumatology, Boston University School of Medicine, Boston, MA, 10Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 11Genentech, Inc., South San Francisco, CA

    Background/Purpose: Factors associated with cumulative glucocorticoid exposure in granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) have not previously been described. We examined the association…
  • Abstract Number: 1936 • 2016 ACR/ARHP Annual Meeting

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study

    Patompong Ungprasert1, Cynthia S. Crowson2, Rodrigo Cartin-Ceba3, James A. Garrity4, Wendy M. Smith5, Ulrich Specks6, Eric L. Matteson1 and Ashima Makol7, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 4Ophthalmology, Mayo Clinic, Rochester, MN, 5Department of Ophthalmology, Mayo Clinic, Rochester, MN, 6Mayo Clinic, Rochester, MN, 7Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is…
  • Abstract Number: 1948 • 2016 ACR/ARHP Annual Meeting

    Evaluation of Body Composition Parameters in Granulomatosis with Polyangiitis: Association of Fat Mass Parameters with Disease Activity and Inflammatory Markers

    Mariana O Perez1, Valeria F Caparbo2, Mauricio Levy-Neto2 and Rosa M R Pereira2, 1Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose:  Granulomatosis with polyangiitis (GPA, Wegener´s) patients are more exposed to traditional cardiovascular risk factor, including obesity. In rheumatic diseases, inflammation has been associated with…
  • Abstract Number: 1954 • 2016 ACR/ARHP Annual Meeting

    Clinical Features and Long Term Outcome of 105 Patients of Granulomatosis with Polyangiitis: A Single Centre Experience from North India

    Aman Sharma1, Shankar Naidu2, Manish Rathi3, Benzeeta Pinto4, Kusum Sharma5, Varun Dhir6, Ritambhra Nada7, Ranjana Minz8 and Surjit Singh9, 1Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2PGIMER, cHANDIGARH, India, 3Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 4PGIMER, CHANDIGARH, India, 5Department of Medical Microbiology,, PGIMER,, Chandigarh, India, 6Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7Histopathology, Professor, Chandigarh, India, 8Department of Immunopathology,, PGIMER,, Chandigarh, India, 9Department of Internal Medicine,, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Background/Purpose: The published Indian data on Granulomatosis with Polyangiitis (GPA) is sparse and only in the form of few small case series. The purpose of this study…
  • Abstract Number: 2079 • 2016 ACR/ARHP Annual Meeting

    Incidence and Risk of Pneumocystis Jirovecii Pneumonia Following Rituximab Treatment in Granulomatosis with Polyangiitis in the United States: An Analysis from a National Database

    Sirada Panupattanapong1, Anthony R. French2, Andrew J. White2, Margaret A. Olsen3, Maya Rendulic4 and Mary E. Hartman5, 1Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, 2Division of Pediatric Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, 3Division of Infectious Disease, Washington University School of Medicine, St. Louis, MO, 4Center for Administrative Data Research, Washington University School of Medicine, St. Louis, MO, 5Division of Pediatric Critical Care Medicine, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO

    Background/Purpose: Pneumocystis Jirovecii pneumonia (PJP) is a life-threatening complication in granulomatosis with polyangiitis (GPA). Guidelines from EULAR for ANCA-associated vasculitis (AAV) recommend institution of PJP…
  • Abstract Number: 853 • 2015 ACR/ARHP Annual Meeting

    Evaluation and Validation of Case-Finding Algorithms for the Identification of Patients with Granulomatosis with Polyangiitis in Large Healthcare Administrative Databases

    Antoine G. Sreih1, Narender Annapureddy2, Kevin Byram3, George Casey4, Vince Frangiosa5, Michael George6, Sapna Sangani7, Rebecca Sharim5 and Peter A. Merkel8, 1Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Rheumatology and Immunology, Vanderbilt University, Nashville, TN, 3Internal Medicine, Vanderbilt University, Nashville, TN, 4The Vasculitis Foundation, Kansas City, MO, 5Rheumatology, University of Pennsylvania, Philadelphia, PA, 6Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, 7Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 8Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: To facilitate clinical care and research, validated algorithms are needed to accurately identify patients with granulomatosis with polyangiitis (GPA; Wegener's). This study, sought to…
  • Abstract Number: 864 • 2015 ACR/ARHP Annual Meeting

    Anticytokine Autoantibody Profiling in Five Types of Systemic Vasculitis

    Sarthak Gupta1,2, Seema K. Patel2, Mary Blake2, Massimo G. Gadina2, Wanxia L. Tsai2, Simon Carette3, David Cuthbertson4, Gary S. Hoffman5, Nader A. Khalidi6, Curry L. Koening7, Carol A. Langford5, Carol A. McAlear8, Larry W. Moreland9, Paul A. Monach10, Christian Pagnoux3, Philip Seo11, Ulrich Specks12, Antoine G. Sreih13, Steven R. Ytterberg14, Sarah K. Browne1,15, Steven M. Holland1, Mariana J. Kaplan2, Peter A. Merkel16, Peter C. Grayson2 and Vasculitis Clinical Research Consortium, 1Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 4Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 5Rheumatology, Cleveland Clinic, Cleveland, OH, 6Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, 7Division of Rheumatology, University of Utah, Salt Lake City, UT, 8Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 9Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 10Rheumatology, Boston University School of Medicine, Boston, MA, 11Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 12Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, 13Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, 14Rheumatology Division, Mayo Clinic, Rochester, MN, 15Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 16Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Anticytokine autoantibodies (ACAs) are pathogenic in many hematologic, pulmonary and infectious diseases. Evaluation in autoimmune diseases, including systemic lupus erythematosus (SLE), shows that ACAs…
  • Abstract Number: 870 • 2015 ACR/ARHP Annual Meeting

    Development of an Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Patient-Reported Outcome Measure: Identification of Salient Themes and Candidate Questionnaire Item Development

    Joanna Robson1, Susan Ashdown2, Jill Dawson3, Ebony Easley4, Don Gebhart5, Katherine Kellom6, Georgia Lanier7, Carol McAlear8, Nataliya Milman9, Jacqueline Peck10, Judy A. Shea11, Gunnar Tomasson12, Raashid Luqmani13, Peter F. Cronholm4 and Peter A. Merkel8, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, University of Oxford, Oxford, United Kingdom, 2NONE, Banbury, United Kingdom, 3Nuffield Department of Population Health HSRU, University of Oxford, Oxford, United Kingdom, 4Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA, 5NONE, Columbus, OH, 6PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, United Kingdom, 7NONE, Framingham, MA, 8Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 9Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, 10NONE, Oxford, United Kingdom, 11Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, United Kingdom, 12Rheumatology Section, Boston University, Boston, MA, 13Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs), including granulomatosis with polyangiitis (Wegener's, (GPA), eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA), and microscopic polyangiitis (MPA),…
  • Abstract Number: 877 • 2015 ACR/ARHP Annual Meeting

    Improved Survival in Granulomatosis with Polyangiitis: A Population-Based Study

    Ju Ann1, Hyon K. Choi2, Sharan K. Rai3, Eric C. Sayre4 and J Antonio Avina-Zubieta5,6, 1Experimental Mediine, University of British Columbia, Richmond, BC, Canada, 2Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, 4Arthritis Research Canada, Richmond, BC, Canada, 5Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, 6Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada

    Background/Purpose: Granulomatosis with Polyangiitis (GPA) is associated with an increased risk of mortality. However, recent mortality trends in GPA are largely unknown, particularly in the…
  • Abstract Number: 888 • 2015 ACR/ARHP Annual Meeting

    Plasma Exchanges to Treat Primary Systemic Necrotizing Vasculitides: Data from a French Nationwide Study

    Gonzalo De Luna1, Dominique Chauveau2, Julien Aniort3, Pierre-Louis Carron4, Pierre Gobert5, Alexandre Karras6, Sylvain Adam-Marchand7, Francois Maurier8, Pierre-Yves Hatron9, Alexandre Mania10, Guillaume Le Guenno11, Stéphane Ballly12, Boris Bienvenu13, Eric Cardineau14, Tiphaine Goulenok15, Noémie Jourde-Chiche Sr.16, Maxime Samson17, Antoine Huart18, Jacques Pourrat19, Aurelien Tiple20, Olivier Aumaître21, Xavier Puéchal22, Farhad Heshmati23, Claire Le Jeunne24, Luc Mouthon25, Loïc Guillevin26 and Benjamin Terrier22, 1Medecine Interne, Cochin University Hospital, Paris, France, 2CH Toulouse, Toulouse, France, 3CHU, Clermont-Ferrand, France, 4Internal Medicine, Centre Hospitalier de Grenoble, Grenoble, France, 5Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 6George Pompidou European Hospital, Paris, France, 7Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 8HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 9Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, 10Hôpital Gabriel Montpied, Clermont-Ferrand, France, 11Internal Medicine department, Clermont-Ferrand, France, 12CH, Chambéry, France, 13Internal Medicine, Hospital Caen, Caen, France, 14CH, Alencon, France, 15University Paris Diderot - APHP - Bichat Hospital, aris, France, 16Nephrology, Aix-Marseille Université - APHM, Marseille, France, 17Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 18CHU, Toulouse, France, 19Nephrology, Rangeuil Hospital, Paris, France, 20Nephrology, CHU, Clermont-Ferrand, France, 21Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, 22Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 23Cochin Hospital, Paris, France, 24Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 25Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, 26Internal Medicine, Hopital Cochin, Paris, France

    Background/Purpose: Plasma exchange (PE) is usually used to treat severe primary systemic necrotizing vasculitides (SNVs) and/or virus-induced vasculitides. Only severe renal insufficiency (serum creatinine (SCR)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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