Abstracts tagged "Vasculitis"

Abstract Number: 1664 • 2019 ACR/ARP Annual Meeting
Reducing the Number of Rituximab Infusions at Onset of Maintenance Therapy for ANCA-associated Vasculitides: Results of a Post Hoc Analysis from a Randomized–controlled Trial
Pierre Charles¹, Agnes Dechartres ², Benjamin Terrier ³, Pascal Cohen ³, Stanislas Faguer ⁴, Antoine Huart ⁴, Mohamed Hamidou ⁵, Christian Agard ⁵, Bernard Bonnotte ⁶, Maxime Samson ⁷, Alexandre Karras ⁸, Noémie Jourde-Chiche ⁹, François Lifermann ¹⁰, Pierre Gobert ¹¹, Catherine Hanrotel-Saliou ¹², Pascal Godmer ¹³, Nicolas Martin-Silva ¹⁴, Grégory Pugnet ¹⁵, Marie Matignon ¹⁶, Olivier Aumaitre ¹⁷, Jean-François Viallard ¹⁸, François Maurier ¹⁹, Nadine Meaux Ruault ²⁰, Sophie Rivière ²¹, Jean Sibilia ²², Xavier Puéchal for the French Vasculitis Study Group ³, Luc Mouthon ³ and Loic Guillevin ³, ¹Institut Mutualiste Montsouris, Paris, France, ²APHP, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, ⁴CHU Toulouse, Toulouse, France, ⁵CHU Nantes, Nantes, France, ⁶Service de Médecine Interne et Immunologie Clinique, CHU Dijon Bourgogne, Hôpital François Mitterrand, Dijon ; Université Bourgogne-Franche Comté, INSERM, EFS BFC, UMR1098, F-21000 Dijon, Dijon, France, ⁷CHU Dijon, Dijon, France, ⁸Paris HEGP, Paris, France, ⁹APHM, Marseille, Marseille, France, ¹⁰CH Dax, Dax, France, ¹¹CH Avignon, Avignon, France, ¹²CHU Brest, Brest, France, ¹³CH Bretagne-Atlantique, Vannes, France, ¹⁴CHU Caen, Caen, France, ¹⁵CHU de Toulouse, Hôpital Purpan, Service de Médecine Interne, Toulouse, France, ¹⁶APHP, Créteil, France, ¹⁷CHU Clermont Ferrand, Clermont Ferrand, France, ¹⁸CHU Bordeaux, Bordeaux, France, ¹⁹Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, ²⁰CHU Besançon, Besançon, France, ²¹CHU Montpellier, Montpellier, France, ²²CHU Strasbourg, Strasbourg, France
Background/Purpose: Rituximab (RTX) superiority over azathioprine to maintain ANCA-associated vasculitis (AAV) remission was demonstrated.The MAINRITSAN2 trial was designed to compare an individually tailored RTX-infusion schedule…
Abstract Number: 1722 • 2019 ACR/ARP Annual Meeting
Mixed Cryoglobulin Immune Complex Proteomics: Analysis by Mass Spectroscopy
Peter Gorevic¹, Frank Eng ², Andrea Branch ³, Ahmed Elshamy ⁴, Erin Doyle ² and Thomas Schiano ², ¹Mount Sinai Hospital, New York, ²Mount Sinai Medical Center, New York, ³Mount Sinai Medical School, New York, ⁴California Northstate University, Sacramento
Background/Purpose: BACKGROUND. Mixed Cryoglobulins (MCs) are cold precipitable Rheumatoid Factors (RFs) that provide a biomarker for immune complex formation, particularly associated with chronic Hepatitis C…
Abstract Number: 2791 • 2019 ACR/ARP Annual Meeting
Treatment Response Criteria for Anti-neutrophil Cytoplasmic Antibodies (ANCA)-vasculitis: Results of a Scoping Review
Sara Monti¹, Kaitlin Quinn ², Robin Christensen ³, Alfred Mahr ⁴, Christian Pagnoux ⁵, Carol Langford ⁶, David Jayne ⁷, Peter Merkel ⁸ and Gunnar Tomasson ⁹, ¹University of Pavia, Pavia, Italy, ²Georgetown University Hospital/National Institutes of Health, Washington, DC, ³Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, ⁴Hospital Saint-Louis, University Paris Diderot, Paris, France, ⁵Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁶Cleveland Clinic, Cleveland, OH, ⁷Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Faculty of Medicine, University of Iceland and Landpitali University Hospital, Reykjavik, Iceland
Background/Purpose: A comprehensive assessment of outcome measures to assess response to treatment in ANCA-associated vasculitis (AAV) is necessary to implement.Methods: We performed a scoping review…
Abstract Number: 1666 • 2019 ACR/ARP Annual Meeting
Maintenance Treatment in ANCA Associated Vasculitis in Real World Clinical Practice – Burden of Disease, Use of Glucocorticoids and Impact on Patient Functional Status Remain Major Problems
Dieter Goette¹ and Peter Rutherford ¹, ¹Vifor Pharma, Zurich, Zurich, Switzerland
Background/Purpose: After successful remission induction AAV is a relapsing remitting long term condition and patients are at risk of organ damage from both active AAV…
Abstract Number: 1745 • 2019 ACR/ARP Annual Meeting
Exercise Improves Arterial Inflammation in Childhood-onset Takayasu Arteritis: A Randomized Controlled Trial
Camilla Astley¹, Gleice Clemente ², Maria Teresa Terreri ³, Camila Carneiro ⁴, Marcos lima ⁴, Carlos Buchpiguel ⁴, Hilton Leão Filho ⁴, Fernanda Lima ¹, Ana Lúcia Sá-Pinto ¹, Clovis Silva ⁵, Nadia Aikawa ⁶, Saulo Gil ¹, Hamilton Roschel ¹, Rosa Pereira ⁷ and Bruno Gualano ¹, ¹Division of Rheumatology, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, sao paulo, Sao Paulo, Brazil, ²ivision of Paediatric Rheumatology, Departament of Paediatrics, Universidade Federal de São Paulo, sao paulo, Sao Paulo, Brazil, ³Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁴Nuclear Medicine Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, sao paulo, Sao Paulo, Brazil, ⁵Pediatric Rheumatology Unit, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁷Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Sao Paulo, Brazil
Background/Purpose: Childhood-onset Takayasu Arteritis (c-TA) is a rare primary systemic vasculitis that affects aorta and its major branches. This condition is associated with reduced wall…
Abstract Number: 2918 • 2019 ACR/ARP Annual Meeting
Metabolic Signatures of Pathogenic T Cells in Medium and Large Vessel Vasculitis
Mitsuhiro Akiyama ¹, Hui Zhang ¹, Ryu Watanabe ¹, Toshihisa Maeda ², Gerald Berry ¹, Jorg Goronzy ¹ and Cornelia Weyand¹, ¹Stanford University, Stanford, CA, ²Matsubara Mayflower Hospital, Kobe, Japan
Background/Purpose: Giant cell arteritis (GCA) is an autoimmune vasculitis that causes aortic arch syndrome, blindnesss, and stroke. Embedded in granulomatous infiltrates, CD4 T cells persist…
Abstract Number: 1667 • 2019 ACR/ARP Annual Meeting
Long Term Outcome of Hydralazine-Associated Vasculitis
Saja Almaaitah¹, Kinanah Yaseen ², Yuxuan Jin ³ and Rula Hajj-ali ⁴, ¹Internal Medicine Residency/Cleveland Clinic, University Heights, OH, ²Cleveland Clinic, Cleveland, OH, ³Quantitative Health Science, Cleveland Clinic, Cleveland, OH, ⁴Rheumatologic and Immunologic Disease/Cleveland Clinic, Cleveland, OH
Background/Purpose: Hydralazine associated vasculitis (HAV) is rare but with potentially detrimental complications, affecting different organ systems. Most case series described short term disease course. Hence,…
Abstract Number: 1747 • 2019 ACR/ARP Annual Meeting
Practice Variations in Treatment of Pediatric Anti-neutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis (AAV) with Renal Disease
Audrea Chen¹, Cherry Mammen ¹, Jaime Guzman ², David Cabral ² and Kimberly Morishita ¹, ¹BC Children's Hospital, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Renal disease is common in ANCA-associated vasculitis (AAV) and one of the goals of early treatment is to maximize renal function recovery. Corticosteroids are…
Abstract Number: 821 • 2018 ACR/ARHP Annual Meeting
Comparison of Aortitis Vs Non-Inflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm Repair
Laarni Quimson¹, Bryan Rea² and Rennie L. Rhee³, ¹Internal Medicine, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Comparison of Aortitis vs Non-Inflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm RepairBackground/Purpose: Distinguishing aortitis-induced aneurysms from more common non-inflammatory aortic aneurysms is…
Abstract Number: 828 • 2018 ACR/ARHP Annual Meeting
Medium and Small-Sized Vessel Involvement in Hypereosinophilic Syndrome
Julien Rohmer¹, Matthieu Groh², Maxime Samson³, Jonathan London⁴, Marie JACHIET⁵, Diane Rouzaud⁶, Antoinette Perlat⁷, Romain Paule⁸, Felipe SUAREZ⁹, Jean-Emmanuel Kahn¹⁰, Loïc Guillevin¹¹ and Benjamin Terrier¹², ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, ²Internal Medicine, Foch, Suresnes, France, ³Dijon University Hospital, Dijon, France, ⁴Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁵Dermatology department, St Louis Hospital, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Internal medicine, CHU de Rennes, Rennes, France, ⁸Department of Internal Medicine, Department of Internal Medicine, Cochin University Hospital, Paris, France, ⁹Hematology Department, Necker Hospital, Paris, France, ¹⁰Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, ¹¹Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹²National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Primary systemic vasculitis, especially eosinophilic granulomatosis with polyangiitis and polyarteritis nodosa, can be associated with blood and tissue eosinophilia. Conversely, eosinophilia in the context…
Abstract Number: 833 • 2018 ACR/ARHP Annual Meeting
11 Patients with Relapsing Polychondritis Presenting with Severe Airways Disease in One Centre in UK
Shirish Dubey¹, Grace Pink², Asad Ali², Nicholas Hart³, Patrick Murphy⁴, Joanne Shakespeare⁵, Colin Gelder⁶, Chris Taylor² and David D'Cruz⁷, ¹Rheumatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ²Respiratory medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ³Respiratory medicine, St Thomas' Hospital, London, United Kingdom, ⁴Lane Fox Respiratory Unit, St Thomas' Hospital, London, United Kingdom, ⁵Respiratory physiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁶University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁷Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom
Background/Purpose: Relapsing polychondritis (RP) is a multi-system disease characterised by episodes of progressive inflammation and subsequent degeneration of cartilage and connective tissue throughout the body.…
Abstract Number: 1317 • 2018 ACR/ARHP Annual Meeting
Tracheomalacia in Coventry in UK
Grace Pink¹, Shirish Dubey², Asad Ali¹, Joanna Shakespeare³, Chris Taylor¹ and Colin Gelder⁴, ¹Respiratory medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ²Rheumatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ³Respiratory Physiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁴University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
Background/Purpose: Tracheomalacia (TM) is pathological diffuse or segmental narrowing of the tracheal lumen, caused by softening of the supporting cartilage and reduction in stiffness of…
Abstract Number: 3079 • 2016 ACR/ARHP Annual Meeting
The Characteristic Features of the Patients with Deficiency of Adenosine Deaminase 2 (DADA2)
Abdulsamet Erden¹, Ezgi Deniz Batu², Ekim Z. Taskiran³, Hafize Emine Sonmez², Alper Sari¹, Berkan Armagan¹, Levent Kilic¹, Zehra Serap Arıcı⁴, Yelda Bilginer⁵, Ali Akdogan¹, Omer Karadag¹, Umut Kalyoncu¹ and Seza Ozen^6,7, ¹Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ²Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Department of Medical Genetics, Hacettepe University Faculty of Medicine, ANKARA, Turkey, ⁴Departments of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁵Departments of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁶Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁷Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey
Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease resulting from a loss-of-function mutation in Cat Eye Syndrome Chromosome Region Candidate…
Abstract Number: 1339 • 2015 ACR/ARHP Annual Meeting
Granulomatosis with Polyangiitis or Post Pulmonary Tuberculosis: Can CT Chest Help in Differentiating in a Tuberculosis Endemic Area?
Aman Sharma¹, Manphool Singhal², Mitali Sen³, Manish Rathi⁴, Varun Dhir¹, Kusum Sharma⁵, Ranjana Minz⁶, Surjit Singh³, Pradeep Bambery⁷ and Niranjan Khandelwal², ¹Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, ²Department of Radiodiagnosis, PGIMER,, Chandigarh, India, ³Department of Internal Medicine,, PGIMER,, Chandigarh, India, ⁴Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁵Department of Medical Microbiology,, PGIMER,, Chandigarh, India, ⁶Department of Immunopathology,, PGIMER,, Chandigarh, India, ⁷Rheumatology, Bundaberg base hospital, University of Queensland, Bundaberg, Australia
Background/Purpose: The data on the Computed tomography (CT) changes of chest in Granulomatosis with polyangiitis (GPA) is available mostly from low tuberculosis prevalence countries. We…
Abstract Number: 1978 • 2015 ACR/ARHP Annual Meeting
Tocilizumab in Refractory Large Vessel Vasculitis with Aorta Involvement. Study on 10 Patients Evaluated By Positron Emission Tomoghraphy
Carlotta Nannini¹, Stelvio Sestini², Laura Niccoli³, Emanuele Cassarà⁴, Olga Kaloudi⁵ and Fabrizio Cantini⁶, ¹Rheumatology, Prato Hospital, Prato, Italy, ²Radiology Department, Prato, Italy, ³Prato Hospital, Prato, Italy, ⁴Rheumatology, Hospital of Prato, Prato, Italy, ⁵PRato, Prato Hospital, Prato, Italy, ⁶Prato, Prato, Italy
Background/Purpose: Large vessel vasculitis (LVV) with aorta involvement are often refractory to common immunosuppressive therapy. Due to the pathogenic role of IL-6 in, we prospectively…

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