ACR Meeting Abstracts

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Abstracts tagged "Vasculitis"

  • Abstract Number: 1664 • 2019 ACR/ARP Annual Meeting

    Reducing the Number of Rituximab Infusions at Onset of Maintenance Therapy for ANCA-associated Vasculitides: Results of a Post Hoc Analysis from a Randomized–controlled Trial

    Pierre Charles1, Agnes Dechartres 2, Benjamin Terrier 3, Pascal Cohen 3, Stanislas Faguer 4, Antoine Huart 4, Mohamed Hamidou 5, Christian Agard 5, Bernard Bonnotte 6, Maxime Samson 7, Alexandre Karras 8, Noémie Jourde-Chiche 9, François Lifermann 10, Pierre Gobert 11, Catherine Hanrotel-Saliou 12, Pascal Godmer 13, Nicolas Martin-Silva 14, Grégory Pugnet 15, Marie Matignon 16, Olivier Aumaitre 17, Jean-François Viallard 18, François Maurier 19, Nadine Meaux Ruault 20, Sophie Rivière 21, Jean Sibilia 22, Xavier Puéchal for the French Vasculitis Study Group 3, Luc Mouthon 3 and Loic Guillevin 3, 1Institut Mutualiste Montsouris, Paris, France, 2APHP, Paris, France, 3National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, 4CHU Toulouse, Toulouse, France, 5CHU Nantes, Nantes, France, 6Service de Médecine Interne et Immunologie Clinique, CHU Dijon Bourgogne, Hôpital François Mitterrand, Dijon ; Université Bourgogne-Franche Comté, INSERM, EFS BFC, UMR1098, F-21000 Dijon, Dijon, France, 7CHU Dijon, Dijon, France, 8Paris HEGP, Paris, France, 9APHM, Marseille, Marseille, France, 10CH Dax, Dax, France, 11CH Avignon, Avignon, France, 12CHU Brest, Brest, France, 13CH Bretagne-Atlantique, Vannes, France, 14CHU Caen, Caen, France, 15CHU de Toulouse, Hôpital Purpan, Service de Médecine Interne, Toulouse, France, 16APHP, Créteil, France, 17CHU Clermont Ferrand, Clermont Ferrand, France, 18CHU Bordeaux, Bordeaux, France, 19Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, 20CHU Besançon, Besançon, France, 21CHU Montpellier, Montpellier, France, 22CHU Strasbourg, Strasbourg, France

    Background/Purpose: Rituximab (RTX) superiority over azathioprine to maintain ANCA-associated vasculitis (AAV) remission was demonstrated.The MAINRITSAN2 trial was designed to compare an individually tailored RTX-infusion schedule…
  • Abstract Number: 1722 • 2019 ACR/ARP Annual Meeting

    Mixed Cryoglobulin Immune Complex Proteomics: Analysis by Mass Spectroscopy

    Peter Gorevic1, Frank Eng 2, Andrea Branch 3, Ahmed Elshamy 4, Erin Doyle 2 and Thomas Schiano 2, 1Mount Sinai Hospital, New York, 2Mount Sinai Medical Center, New York, 3Mount Sinai Medical School, New York, 4California Northstate University, Sacramento

    Background/Purpose: BACKGROUND. Mixed Cryoglobulins (MCs) are cold precipitable Rheumatoid Factors (RFs) that provide a biomarker for immune complex formation, particularly associated with chronic Hepatitis C…
  • Abstract Number: 2791 • 2019 ACR/ARP Annual Meeting

    Treatment Response Criteria for Anti-neutrophil Cytoplasmic Antibodies (ANCA)-vasculitis: Results of a Scoping Review

    Sara Monti1, Kaitlin Quinn 2, Robin Christensen 3, Alfred Mahr 4, Christian Pagnoux 5, Carol Langford 6, David Jayne 7, Peter Merkel 8 and Gunnar Tomasson 9, 1University of Pavia, Pavia, Italy, 2Georgetown University Hospital/National Institutes of Health, Washington, DC, 3Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, 4Hospital Saint-Louis, University Paris Diderot, Paris, France, 5Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, 6Cleveland Clinic, Cleveland, OH, 7Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, 8University of Pennsylvania, Philadelphia, PA, 9Faculty of Medicine, University of Iceland and Landpitali University Hospital, Reykjavik, Iceland

    Background/Purpose: A comprehensive assessment of outcome measures to assess response to treatment in ANCA-associated vasculitis (AAV) is necessary to implement.Methods: We performed a scoping review…
  • Abstract Number: 1666 • 2019 ACR/ARP Annual Meeting

    Maintenance Treatment in ANCA Associated Vasculitis in Real World Clinical Practice – Burden of Disease, Use of Glucocorticoids and Impact on Patient Functional Status Remain Major Problems

    Dieter Goette1 and Peter Rutherford 1, 1Vifor Pharma, Zurich, Zurich, Switzerland

    Background/Purpose: After successful remission induction AAV is a relapsing remitting long term condition and patients are at risk of organ damage from both active AAV…
  • Abstract Number: 1745 • 2019 ACR/ARP Annual Meeting

    Exercise Improves Arterial Inflammation in Childhood-onset Takayasu Arteritis: A Randomized Controlled Trial

    Camilla Astley1, Gleice Clemente 2, Maria Teresa Terreri 3, Camila Carneiro 4, Marcos lima 4, Carlos Buchpiguel 4, Hilton Leão Filho 4, Fernanda Lima 1, Ana Lúcia Sá-Pinto 1, Clovis Silva 5, Nadia Aikawa 6, Saulo Gil 1, Hamilton Roschel 1, Rosa Pereira 7 and Bruno Gualano 1, 1Division of Rheumatology, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, sao paulo, Sao Paulo, Brazil, 2ivision of Paediatric Rheumatology, Departament of Paediatrics, Universidade Federal de São Paulo, sao paulo, Sao Paulo, Brazil, 3Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, 4Nuclear Medicine Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, sao paulo, Sao Paulo, Brazil, 5Pediatric Rheumatology Unit, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, 6Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, 7Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Sao Paulo, Brazil

    Background/Purpose: Childhood-onset Takayasu Arteritis (c-TA) is a rare primary systemic vasculitis that affects aorta and its major branches. This condition is associated with reduced wall…
  • Abstract Number: 2918 • 2019 ACR/ARP Annual Meeting

    Metabolic Signatures of Pathogenic T Cells in Medium and Large Vessel Vasculitis

    Mitsuhiro Akiyama 1, Hui Zhang 1, Ryu Watanabe 1, Toshihisa Maeda 2, Gerald Berry 1, Jorg Goronzy 1 and Cornelia Weyand1, 1Stanford University, Stanford, CA, 2Matsubara Mayflower Hospital, Kobe, Japan

    Background/Purpose: Giant cell arteritis (GCA) is an autoimmune vasculitis that causes aortic arch syndrome, blindnesss, and stroke. Embedded in granulomatous infiltrates, CD4 T cells persist…
  • Abstract Number: 1667 • 2019 ACR/ARP Annual Meeting

    Long Term Outcome of Hydralazine-Associated Vasculitis

    Saja Almaaitah1, Kinanah Yaseen 2, Yuxuan Jin 3 and Rula Hajj-ali 4, 1Internal Medicine Residency/Cleveland Clinic, University Heights, OH, 2Cleveland Clinic, Cleveland, OH, 3Quantitative Health Science, Cleveland Clinic, Cleveland, OH, 4Rheumatologic and Immunologic Disease/Cleveland Clinic, Cleveland, OH

    Background/Purpose: Hydralazine associated vasculitis (HAV) is rare but with potentially detrimental complications, affecting different organ systems. Most case series described short term disease course. Hence,…
  • Abstract Number: 1747 • 2019 ACR/ARP Annual Meeting

    Practice Variations in Treatment of Pediatric Anti-neutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis (AAV) with Renal Disease

    Audrea Chen1, Cherry Mammen 1, Jaime Guzman 2, David Cabral 2 and Kimberly Morishita 1, 1BC Children's Hospital, Vancouver, BC, Canada, 2University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Renal disease is common in ANCA-associated vasculitis (AAV) and one of the goals of early treatment is to maximize renal function recovery. Corticosteroids are…
  • Abstract Number: 821 • 2018 ACR/ARHP Annual Meeting

    Comparison of Aortitis Vs Non-Inflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm Repair

    Laarni Quimson1, Bryan Rea2 and Rennie L. Rhee3, 1Internal Medicine, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Comparison of Aortitis vs Non-Inflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm RepairBackground/Purpose: Distinguishing aortitis-induced aneurysms from more common non-inflammatory aortic aneurysms is…
  • Abstract Number: 828 • 2018 ACR/ARHP Annual Meeting

    Medium and Small-Sized Vessel Involvement in Hypereosinophilic Syndrome

    Julien Rohmer1, Matthieu Groh2, Maxime Samson3, Jonathan London4, Marie JACHIET5, Diane Rouzaud6, Antoinette Perlat7, Romain Paule8, Felipe SUAREZ9, Jean-Emmanuel Kahn10, Loïc Guillevin11 and Benjamin Terrier12, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, 2Internal Medicine, Foch, Suresnes, France, 3Dijon University Hospital, Dijon, France, 4Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 5Dermatology department, St Louis Hospital, Paris, France, 6Université Paris-Diderot, Paris, France, 7Internal medicine, CHU de Rennes, Rennes, France, 8Department of Internal Medicine, Department of Internal Medicine, Cochin University Hospital, Paris, France, 9Hematology Department, Necker Hospital, Paris, France, 10Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, 11Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 12National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France

    Background/Purpose: Primary systemic vasculitis, especially eosinophilic granulomatosis with polyangiitis and polyarteritis nodosa, can be associated with blood and tissue eosinophilia. Conversely, eosinophilia in the context…
  • Abstract Number: 833 • 2018 ACR/ARHP Annual Meeting

    11 Patients with Relapsing Polychondritis Presenting with Severe Airways Disease in One Centre in UK

    Shirish Dubey1, Grace Pink2, Asad Ali2, Nicholas Hart3, Patrick Murphy4, Joanne Shakespeare5, Colin Gelder6, Chris Taylor2 and David D'Cruz7, 1Rheumatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 2Respiratory medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 3Respiratory medicine, St Thomas' Hospital, London, United Kingdom, 4Lane Fox Respiratory Unit, St Thomas' Hospital, London, United Kingdom, 5Respiratory physiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 6University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 7Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom

    Background/Purpose: Relapsing polychondritis (RP) is a multi-system disease characterised by episodes of progressive inflammation and subsequent degeneration of cartilage and connective tissue throughout the body.…
  • Abstract Number: 1317 • 2018 ACR/ARHP Annual Meeting

    Tracheomalacia in Coventry in UK

    Grace Pink1, Shirish Dubey2, Asad Ali1, Joanna Shakespeare3, Chris Taylor1 and Colin Gelder4, 1Respiratory medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 2Rheumatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 3Respiratory Physiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 4University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

    Background/Purpose: Tracheomalacia (TM) is pathological diffuse or segmental narrowing of the tracheal lumen, caused by softening of the supporting cartilage and reduction in stiffness of…
  • Abstract Number: 3079 • 2016 ACR/ARHP Annual Meeting

    The Characteristic Features of the Patients with Deficiency of Adenosine Deaminase 2 (DADA2)

    Abdulsamet Erden1, Ezgi Deniz Batu2, Ekim Z. Taskiran3, Hafize Emine Sonmez2, Alper Sari1, Berkan Armagan1, Levent Kilic1, Zehra Serap Arıcı4, Yelda Bilginer5, Ali Akdogan1, Omer Karadag1, Umut Kalyoncu1 and Seza Ozen6,7, 1Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Department of Medical Genetics, Hacettepe University Faculty of Medicine, ANKARA, Turkey, 4Departments of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 5Departments of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 6Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey, 7Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey

    Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease resulting from a loss-of-function mutation in Cat Eye Syndrome Chromosome Region Candidate…
  • Abstract Number: 1339 • 2015 ACR/ARHP Annual Meeting

    Granulomatosis with Polyangiitis or Post Pulmonary Tuberculosis: Can CT Chest Help in Differentiating in a Tuberculosis Endemic Area?

    Aman Sharma1, Manphool Singhal2, Mitali Sen3, Manish Rathi4, Varun Dhir1, Kusum Sharma5, Ranjana Minz6, Surjit Singh3, Pradeep Bambery7 and Niranjan Khandelwal2, 1Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Department of Radiodiagnosis, PGIMER,, Chandigarh, India, 3Department of Internal Medicine,, PGIMER,, Chandigarh, India, 4Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 5Department of Medical Microbiology,, PGIMER,, Chandigarh, India, 6Department of Immunopathology,, PGIMER,, Chandigarh, India, 7Rheumatology, Bundaberg base hospital, University of Queensland, Bundaberg, Australia

    Background/Purpose: The data on the Computed tomography (CT) changes of chest in Granulomatosis with polyangiitis (GPA) is available mostly from low tuberculosis prevalence countries. We…
  • Abstract Number: 1978 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab in Refractory Large Vessel Vasculitis with Aorta Involvement. Study on 10 Patients Evaluated By Positron Emission Tomoghraphy

    Carlotta Nannini1, Stelvio Sestini2, Laura Niccoli3, Emanuele Cassarà4, Olga Kaloudi5 and Fabrizio Cantini6, 1Rheumatology, Prato Hospital, Prato, Italy, 2Radiology Department, Prato, Italy, 3Prato Hospital, Prato, Italy, 4Rheumatology, Hospital of Prato, Prato, Italy, 5PRato, Prato Hospital, Prato, Italy, 6Prato, Prato, Italy

    Background/Purpose: Large vessel vasculitis (LVV) with aorta involvement are often refractory to common immunosuppressive therapy. Due to the pathogenic role of IL-6 in, we prospectively…
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