ACR Meeting Abstracts

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Abstracts tagged "Vasculitis"

  • Abstract Number: 1617 • ACR Convergence 2022

    Direct Comparison of Ultrasound, [18F]Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging: Early Diagnostics in Patients Suspected of Giant Cell Arteritis

    Marieke van Nieuwland1, Marloes Vermeer1, Edgar Colin2, Nils Wagenaar1, Onno Vijlbrief1, Jordy van Zandwijk3, Riemer Slart4, Hendrik Koffijberg3, Erik Groot Jebbink3, Elisabeth Brouwer4, Dennis Boumans1 and Celina Alves1, 1Hospital Group Twente, Almelo, Netherlands, 2Hospital Group Twente, Deventer, Netherlands, 3University of Twente, Enschede, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Giant cell arteritis (GCA) requires rapid diagnostic work up and start of treatment to prevent severe complications. The temporal artery biopsy as a gold…
  • Abstract Number: 0438 • ACR Convergence 2022

    Characterization of Interstitial Lung Disease in the Presence of Antineutrophil Cytoplasmic Antibodies

    Khai-Tuan Andrew Bui1, Rachel Richard2, Ariane Drouin3, Nader Toban1, Marianne Levesque4, Rosalie-Selene Meunier5, Carolyn Ross6 and Jean-Paul Makhzoum3, 1Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 2Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Laval, QC, Canada, 3Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 4Division of Respirology, Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 5Hopital Sacre-Coeur, Universite de Montreal, Montréal, QC, Canada, 6University of Montreal, Montréal, QC, Canada

    Background/Purpose: Various pulmonary manifestations may occur in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCA-related interstitial lung disease (ILD) has recently been described in…
  • Abstract Number: 0470 • ACR Convergence 2022

    Long-term Efficacy of Tocilizumab Monotherapy After Ultra-short Glucocorticoid Administration to Treat Giant Cell Arteritis – One Year Follow-up of the GUSTO Trial

    Lisa Christ1, Luca Seitz2, Godehard Scholz1, Lukas Buetikofer3, Florian Kollert1, Stephan Reichenbach4 and Peter Villiger5, 1Department of Rheumatology and Immunology, University of Bern, Inselspital, Bern, Switzerland, 2Department of Rheumatology and Immunology, University of Bern, Inselspital, Switzerland, 3CTU Bern, University of Bern, Bern, Switzerland, 4University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland, 5Medical Center Monbijou, Rheumatology and Immunology, Bern, Switzerland

    Background/Purpose: Two randomised controlled trials (RCT) [1, 2] demonstrated a glucocorticoid (GC)-sparing effect of tocilizumab (TCZ) of at least 50% in the treatment of giant…
  • Abstract Number: 0526 • ACR Convergence 2022

    Characteristics and Outcomes of Participants with and Without Diffuse Alveolar Hemorrhage in the Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis (PEXIVAS) Trial

    Lynn Fussner1, Luis Felipe Flores-Suarez2, Rodrigo Cartin-Ceba3, Ulrich Specks3, P. Gerard Cox4, David Jayne5, Peter Merkel6 and Michael Walsh4, 1The Ohio State University, Columbus, OH, 2Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, Mexico, 3Mayo Clinic, Rochester, MN, 4McMaster University, Hamilton, ON, Canada, 5University of Cambridge, Cambridge, United Kingdom, 6University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a potentially life-threatening manifestation of ANCA-associated vasculitis (AAV). Studies describing patients with DAH in AAV have typically been small…
  • Abstract Number: 1237 • ACR Convergence 2022

    Assessment of Common Femoral Vein Intima-Media Thickness by Ultrasound in Behçet’s Disease: Comparative Study of Patients with or Without Vascular Involvement in a National Referral Center

    Diana Prieto-Peña1, Alfonso del Peral-Fanjul2, Belén Atienza-Mateo1, Veronica Pulito-Cueto1, Miguel Ángel González-Gay3 and Ricardo Blanco4, 1Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain, Spain, 3Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Clinical vascular involvement is present in up to 40% of patients with Behçet’s disease (BD). Increased venous wall thickness assessed with ultrasound (US) has…
  • Abstract Number: 1561 • ACR Convergence 2022

    Development of Posterior Uveitis in Behçet’s Syndrome Patients with Vitreous Cells Without Any Other Posterior Involvement

    Didar Ucar1, Basak Ecem Bircan2, Nigar Rustamli3, Bilge Batu Oto1, Vedat Hamuryudan4, Sinem Nihal Esatoglu5 and gulen Hatemi5, 1Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Ophthalmology, Istanbul, Turkey, 2Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, 3Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Internal Medicine, Istanbul, Turkey, 4Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: A considerable number of patients with Behçet's syndrome (BS) have vitreous cells on slit lamp examination at the time of diagnosis. However, the prognostic…
  • Abstract Number: 1619 • ACR Convergence 2022

    Silent Giant Cell Arteritis in Patients with Polymyalgia Rheumatica: Characteristics and Peculiarities

    Eugenio De Miguel1, PIERLUIGI MACCHIONI2, Edoardo Conticini3, Corrado Campochiaro4, Rositsa Karalilova5, Sara Monti6, Cristina Ponte7, Giulia Klinowski2, Irene Monjo8, Paolo Paolo Falsetti3, Anastas Batalov9, alessandro tomelleri4 and Alojzija Hocevar10, 1Hospital Universitario La Paz, Madrid, Spain, 2IRCCS-S.Maria Nuova, Reggio Emilia, Italy, 3Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy, 4IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milano, Italy, 5Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria, 6Rheumatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, 7Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte EPE, Lisboa, Portugal, 8Hospital Universitario La Paz - IdiPAZ, Madrid, Spain, 9Medical University of Plovdiv, Plovdiv, Bulgaria, 10University Medical Centre Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are closely related diseases. PMR occurs in approximately 50 % of patients with GCA. In a…
  • Abstract Number: 0439 • ACR Convergence 2022

    Clinical Characteristics of Patients with ANCA-Associated Vasculitis with and Without Alpha-1 Antitrypsin Deficiency Alleles

    Lynn Fussner1, David Cuthbertson2, Peter Grayson3, David Jayne4, Carol McAlear5, Michael Walsh6, Katherine Siminovitch7, Ulrich Specks8 and Peter Merkel9, 1The Ohio State University, Columbus, OH, 2University of South Florida, Tampa, FL, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4University of Cambridge, Cambridge, United Kingdom, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 6McMaster University, Hamilton, ON, Canada, 7University of Toronto, Toronto, ON, Canada, 8Mayo Clinic, Rochester, MN, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: There are multiple reasons to suspect that alpha-1 antitrypsin (A1AT) genotype impacts disease characteristics in ANCA-associated vasculitis (AAV). A1AT serves as the predominant endogenous…
  • Abstract Number: 0471 • ACR Convergence 2022

    Serum Proteomics in Giant Cell Arteritis: Findings of the Giant Cell Arteritis Treatment with Ultra-short Glucocorticoids and Tocilizumab Trial (The GUSTO Trial)

    Lisa Christ1, Andrea Gloor2, Florian Kollert1, Timo Gaber3, Frank Buttgereit3, Stephan Reichenbach4 and Peter Villiger5, 1Department of Rheumatology and Immunology, University of Bern, Inselspital, Bern, Switzerland, 2Department of Internal Medicine, University of Bern, Inselspital, Bern, Switzerland, 3Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany, 4University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland, 5Medical Center Monbijou, Rheumatology and Immunology, Bern, Switzerland

    Background/Purpose: Measuring disease activity in patients with giant cell arteritis (GCA) remains challenging since appropriate biomarkers are missing, particularly, if tocilizumab (TCZ) is prescribed which…
  • Abstract Number: 0529 • ACR Convergence 2022

    Complex Relationships Between Inflammation and Clonal Hematopoiesis in Systemic Vasculitis

    Adrianna Jones1, Kristina Wells1, Fernanda Gutierrez-Rodrigues2, Cameron Rankin3, Wanxia Tsai3, Bhavisha Patel4, Kaitlin Quinn1, Dalton Hironaka2, Massimo Gadina5, Keith Sikora1, Neal Young2 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 3NIAMS/NIH, Bethesda, MD, 4National Institutes of Health, Beltsville, MD, 5Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by somatic mutations in a set of genes commonly associated with myeloid neoplasms in an otherwise…
  • Abstract Number: 1251 • ACR Convergence 2022

    Venous Halo Sign Detected with Superb Microvascular Imaging in Behçet Syndrome

    Yasemin Kayadibi1, Yesim Ozguler2, Melike Melikoglu3, Sinem Nihal Esatoglu3, Ahmet Ustundag1, Ugur Kimyon4, Ayse Kalyoncu Ucar1, Ibrahim Adaletli1 and gulen Hatemi3, 1Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Radiology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 3Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 4Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Internal Medicine, Istanbul, Turkey

    Background/Purpose: Superb microvascular imaging (SMI) is a novel technique that provides a more sensitive assessment of small vessels compared to color Doppler US (CDUS), by…
  • Abstract Number: 1564 • ACR Convergence 2022

    Anti-TNF versus Anti-IL6 Receptor Antagonist Therapy in Severe Ocular Involvement in Behçet’s Disease

    Nuria Barroso-García1, Belén Atienza-Mateo2, Ivan Ferraz Amaro3, Diana Prieto-Peña2, Ana De Vicente-Delmás4, Ricardo Blanco5 and Miguel Ángel González-Gay6, 1Hospital Universitario Puerta del Mar, Cádiz, Spain, Cádiz, Spain, 2Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 4Hospital General Santa María del Puerto, Cádiz, Spain, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: To evaluate the efficacy of anti-TNF or anti-IL6 treatment in severe and refractory ocular involvement in patients with refractory cystoid macular edema (CME) due…
  • Abstract Number: 1620 • ACR Convergence 2022

    Probability-based Diagnostic Algorithm in Suspected Giant Cell Arteritis: A Prospective, Multicentre Validity Data from HAS GCA Study

    Alwin Sebastian1, alessandro tomelleri2, PIERLUIGI MACCHIONI3, Giulia Klinowski3, Carlo Salvarani4, Abdul Kayani5, Mohammad Tariq5, Diana Prieto-Peña6, Edoardo Conticini7, Muhammad Khurshid8, Sue Inness9, Jo Jackson9, Kornelis van der Geest10 and Bhaskar Dasgupta5, 1University Hospital Limerick, Dooradoyle, Ireland, 2IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milano, Italy, 3IRCCS-S.Maria Nuova, Reggio Emilia, Italy, 4Azienda USL -IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Reggio Emilia, Italy, 5Mid and South Essex University Hospital Groups, Southend, United Kingdom, 6Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 7Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy, 8University Hospital Dorset, NHS foundation trust, UK, Poole, United Kingdom, 9University of Essex, School of Sport, Rehabilitation and Exercise science, Colchester, United Kingdom, 10University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: The presentation of new-onset giant cell arteritis (GCA) is highly variable. It is vital to make a secure diagnosis to minimise the risk for…
  • Abstract Number: 0443 • ACR Convergence 2022

    Prognosis of Non-PR3 ANCA-Associated Vasculitis with Glomerulonephritis

    Aurélien Chepy1, Hélène Béhal2, Alexandre Karras3, Xavier Puéchal4, Benjamin Terrier4, David Jayne5, Thomas Quéméneur6 and Mary-Jane Guerry7, 1CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France, 2University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, Lille, France, 3HEGP, Paris, France, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 5University of Cambridge, Cambridge, United Kingdom, 6Valenciennes Hospital, Valenciennes, France, 7Department of Nephrology, Centre Hospitalier de Valenciennes, Valenciennes., Valenciennes, France

    Background/Purpose: Immunosuppressive treatments have improved the prognosis of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), transforming these formerly fatal diseases into chronic conditions, with periods of…
  • Abstract Number: 0472 • ACR Convergence 2022

    The Common Carotid Artery in the Ultrasound Evaluation of Giant Cell Arteritis

    Charles Oshinsky1, Alison Bays1, Ingeborg Sacksen1, Elizabeth Jernberg2, R. Eugene zierler1 and Scott Pollock1, 1University of Washington, Seattle, WA, 2Virginia Mason, Seattle, WA

    Background/Purpose: Giant cell arteritis (GCA), the most common large vessel vasculitis, can cause irreversible vision loss if untreated. Vascular ultrasound has been used with greater…
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