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Abstracts tagged "tyrosine kinase inhibition and anti-TNF therapy"

  • Abstract Number: 810 • 2019 ACR/ARP Annual Meeting

    Small Vessel Vasculitis Syndrome with Autoinflammation Caused by De Novo Mutations in LYN Kinase

    Adriana de Jesus1, Gina Montealegre Sanchez 2, Helen Freeman 3, Neil Martin 4, Ebun Omoyinmi 5, Katherine Calvo 6, Richard Chyi-chia Lee 7, Murray Passo 8, Natasha Ruth 8, David Kleiner 7, Yan Huang 9, Nirali Shah 10, Paul Brogan 11, SuJin Hwang 12, HyeSun Kuehn 12, Sergio Rosenzweig 12, Zuoming Deng 13, Anna Huttenlocher 14, Susan Moir 15, Douglas Kuhns 16 and Raphaela Goldbach-Mansky 17, 1Translation Autoinflammatory Diseases Section/NIAID/NIH, Silver Spring, MD, 2Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, 3Raigmore Hospital, Inverness, United Kingdom, 4Royal Hospital for Children, Glasgow, United Kingdom, 5University College London Institute of Child Health, London, United Kingdom, 6Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, 7Laboratory of Pathology/NCI/NIH, Bethesda, MD, 8Medical University of South Carolina, Charleston, SC, 9Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, 10Pediatric Oncology Branch/NCI/NIH, Bethesda, MD, 11Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 12Immunology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, 13Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, 14Department of Pediatrics/University of Wisconsin, Madison, WI, 15Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, 16Collaborative Clinical Research Branch/NIAID/NIH, Bethesda, MD, 17Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD

    Background/Purpose: Lyn kinase is a member of the Src family of non-receptor tyrosine-protein kinases that modifies signals from various cell surface receptors and regulates innate…
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