Abstracts tagged "tumor necrosis factor (TNF) and mouse model"

Abstract Number: 809 • 2019 ACR/ARP Annual Meeting
TNF-α Drives Progressive Obliterative Pulmonary Vascular Disease and Represents a Novel Model of Connective-Tissue Disease Associated Pulmonary Arterial Hypertension (CTD-PAH)
Benjamin Korman¹, Richard Bell ¹, R James White ², Maria de la luz Garcia-Hernandez ³, Emily Wu ², Pamela Slattery ², Nelson Huertas ², Stacey Duemmel ², Marc Nuzzo ², Homaira Rahimi ⁴, Craig Morrell ², Christopher Ritchlin ³ and Edward Schwarz ², ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester, Rochester, NY, ³Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ⁴University of Rochester Medical Center, Rochester
Background/Purpose: Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by an obliterative vasculopathy and vascular remodeling, right heart hypertrophy, and premature death. Connective…

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