Abstracts tagged "Treg and Enthesitis"

Abstract Number: 121 • 2019 ACR/ARP Annual Meeting
In Vitro Human Enthesitis Model with Induced IL-17A and TNFα from CD4+ and CD8+ T Cells and Effect of Pharmacological Antagonism with Janus Kinase and Retinoic Acid Receptor-related Orphan Receptor γ Inhibition
Hannah Rowe¹, Abdulla Watad ², Charles Bridgewood ¹, Tobias Russell ³, Darren Newton ⁴, Miriam Wittmann ⁵, Qiao Zhou ⁶, Almas Khan ⁷, Robert Dunsmuir ⁷, Peter Loughenbury ⁷, Richard Cuthbert ³ and Dennis McGonagle ⁶, ¹Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom, ²Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, England, United Kingdom, ⁴Leeds Institute of Rheumatic and Muscoskeletal Medicine, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, United Kingdom, ⁶University of Leeds, Leeds, United Kingdom, ⁷Leeds Teaching Hospitals NHS Trust, Leeds
Background/Purpose: Animal models of experimental spondyloarthritis (SpA), human genetics and therapies support a central role for adaptive immunity in disease pathogenesis. However, there is very…

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